Results 191 to 200 of about 234,206 (306)

Expression of coxsackie and adenovirus receptor distinguishes transitional cancer states in therapy-induced cellular senescence [PDF]

, 2010
Peter Wu, Q Wang, Zening Dong, Emily Y. Chu, Rachel Roberson, Iana Ivanova, Daniel Wu   +6 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Immunosuppressive macrophages determine the effect of cellular senescence on tumor progression. [PDF]

Sci Adv
Lalinde-Gutiérrez M, Pérez-Ramos S, Rodilla V, Garcia-Baucells P, Perera-Bel J, Berenguer-Molins P, Nonell L, Agustí-Barea I, George C, Arribas J.   +9 more
europepmc   +1 more source

The role of high mobility group proteins in cellular senescence mechanisms [PDF]

Jia Chen, Hongyu Li, Yongyin Huang, Qiang Tang   +3 more
openalex   +1 more source

Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging [PDF]

, 2014
Dorian V. Ziegler, Christopher D. Wiley, Michael C. Velarde   +2 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Rhapontigenin alleviates cellular senescence and physiological aging by upregulating sirt1 and promoting autophagy. [PDF]

Chin Med
Liu S, Chen W, Xu G, Liu X, Shi Y, Wang G, Ning Y, Cao Y, Li M, Zhao Y.   +9 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

SenSeqNet: A Deep Learning Framework for Cellular Senescence Detection From Protein Sequences. [PDF]

Aging Cell
Jiang H, Deng D, Yuan Y, Ren J, Yang X, Liu S, Tan B, Lin L, Liu L.   +8 more
europepmc   +1 more source

The signalling axis CDK12-BRCA1 mediates dinaciclib associated radiosensitivity through p53-mediated cellular senescence [PDF]

Natalia García-Flores, Diego M. Fernández‐Aroca, Cristina Garnés‐García, Andrés Domínguez‐Calvo, S. Sabater, Ignacio Andrés, Jaime Jiménez‐Suárez, Pablo Fernández‐Aroca, Francisco J. Cimas, Guillermo de Cárcer, Borja Belandia, Ignacio Palmero, Pablo Huertas, María José Ruiz‐Hidalgo, Ricardo Sánchez‐Prieto   +14 more
openalex   +1 more source