Results 221 to 230 of about 1,861,365 (381)

The role of cellular senescence in ageing and endocrine disease

Nature Reviews Endocrinology, 2020
S. Khosla, J. Farr, T. Tchkonia, J. Kirkland   +3 more
semanticscholar   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Subtractive screening of genes involved in cellular senescence.

, 2001
Norihisa Uehara, Yoshinori Katakura, Takumi Miura, Sanetaka Shirahata   +3 more
openalex   +2 more sources

Cellular senescence in cancer treatment: friend or foe? [PDF]

, 2004
Pascal Kahlem, Bernd Dörken, Clemens A. Schmitt   +2 more
openalex   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Cellular Senescence Requires CDK5 Repression of Rac1 Activity [PDF]

, 2004
Kamilah Alexander, Hai-Su Yang, Philip W. Hinds   +2 more
openalex   +1 more source

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

, 2002
Elizabeth Langley
openalex   +2 more sources

DNA end joining becomes less efficient and more error-prone during cellular senescence [PDF]

, 2004
Andrei Seluanov, David Mittelman, Olivia M. Pereira‐Smith, John H. Wilson, Vera Gorbunova   +4 more
openalex   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source