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Current Opinion in Cell Biology, 1991
Differentiated eukaryotic cells have only a finite capacity for cell division. This limitation is thought to be a cellular manifestation of organismal aging, and a restraint to tumor progression. The molecular basis for cellular senescence is not known, but a molecular framework for understanding this phenomenon has recently been established.
A, McCormick, J, Campisi
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Differentiated eukaryotic cells have only a finite capacity for cell division. This limitation is thought to be a cellular manifestation of organismal aging, and a restraint to tumor progression. The molecular basis for cellular senescence is not known, but a molecular framework for understanding this phenomenon has recently been established.
A, McCormick, J, Campisi
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Markers of Cellular Senescence
2012Cellular senescence is a tumor suppression mechanism that evolved to limit duplication in somatic cells. Senescence is imposed by natural replicative boundaries or stress-induced signals, such as oncogenic transformation. Neoplastic cells can be forced to undergo senescence through genetic manipulations and epigenetic factors, including anticancer ...
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Cellular senescence and PAPP-A
Growth Hormone & IGF ResearchCellular senescence and its accompanying secretome have major impact on growth and aging of mammalian organisms. A novel protease, PAPP-A, regulates the bioavailability of an important growth factor, insulin-like growth factor (IGF)-I, and has major impact on growth and aging.
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2015
The term senescence was coined more than 50 years ago to describe the loss of replicative capacity of normal human diploid cells in culture.1 At that time, senescence was proposed to generally reflect the process of cellular aging.2., 3. Early studies also noted differences between the propensity of normal and malignant cells to senesce, with malignant
Bolden, Jessica E., Lowe, Scott W.
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The term senescence was coined more than 50 years ago to describe the loss of replicative capacity of normal human diploid cells in culture.1 At that time, senescence was proposed to generally reflect the process of cellular aging.2., 3. Early studies also noted differences between the propensity of normal and malignant cells to senesce, with malignant
Bolden, Jessica E., Lowe, Scott W.
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Cellular senescence: the good, the bad and the unknown
Nature Reviews Nephrology, 2022Weijun Huang +2 more
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Cellular senescence in ageing: from mechanisms to therapeutic opportunities
Nature Reviews Molecular Cell Biology, 2020Raffaella Di Micco +2 more
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Cellular senescence and cardiovascular diseases: moving to the “heart” of the problem
Physiological Reviews, 2023Konstantinos Evangelou +2 more
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The role of cellular senescence in ageing and endocrine disease
Nature Reviews Endocrinology, 2020Sundeep Khosla +2 more
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