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Journal of Neuro-Oncology, 2023
Glioma is the most common primary brain tumor and is often associated with treatment resistance and poor prognosis. Standard treatment typically involves radiotherapy and temozolomide-based chemotherapy, both of which induce cellular senescence-a tumor suppression mechanism.Gliomas employ various mechanisms to bypass or escape senescence and remain in ...
Rafał, Chojak +3 more
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Glioma is the most common primary brain tumor and is often associated with treatment resistance and poor prognosis. Standard treatment typically involves radiotherapy and temozolomide-based chemotherapy, both of which induce cellular senescence-a tumor suppression mechanism.Gliomas employ various mechanisms to bypass or escape senescence and remain in ...
Rafał, Chojak +3 more
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2015
The term senescence was coined more than 50 years ago to describe the loss of replicative capacity of normal human diploid cells in culture.1 At that time, senescence was proposed to generally reflect the process of cellular aging.2., 3. Early studies also noted differences between the propensity of normal and malignant cells to senesce, with malignant
Bolden, Jessica E., Lowe, Scott W.
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The term senescence was coined more than 50 years ago to describe the loss of replicative capacity of normal human diploid cells in culture.1 At that time, senescence was proposed to generally reflect the process of cellular aging.2., 3. Early studies also noted differences between the propensity of normal and malignant cells to senesce, with malignant
Bolden, Jessica E., Lowe, Scott W.
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Phosphate and Cellular Senescence
2022Cellular senescence is one type of permeant arrest of cell growth and one of increasingly recognized contributor to aging and age-associated disease. High phosphate and low Klotho individually and synergistically lead to age-related degeneration in multiple organs.
Ming Chang, Hu, Orson W, Moe
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Hypertension and cellular senescence
Biogerontology, 2023Essential or primary hypertension is a wordwide health problem. Elevated blood pressure (BP) is closely associated not only with increased chronological aging but also with biological aging. There are various common pathways that play a role in cellular aging and BP regulation.
Baris, Afsar, Rengin Elsurer, Afsar
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Cellular senescence and neurodegeneration
Human Genetics, 2023Advancing age is a major risk factor of Alzheimer's disease (AD). The worldwide prevalence of AD is approximately 50 million people, and this number is projected to increase substantially. The molecular mechanisms underlying the aging-associated susceptibility to cognitive impairment in AD are largely unknown.
Kristopher Holloway +3 more
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Genetics of cellular senescence
Mechanisms of Ageing and Development, 2002Cellular senescence or replicative senescence is a state of irreversible growth arrest that somatic cells enter as a result of replicative exhaustion. This can be mimicked by culture manipulations such as Ras oncogene overexpression or treatment with various agents such as sodium butyrate and 5-azacytidine.
Kaoru, Tominaga +3 more
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Abstract The molecular constituents of cells naturally deteriorate over time, raising the possibility of senescence in unicellular organisms analogous to the somatic aging that occurs in multicellular species. Studying this process requires a means for discriminating between parent and offspring cells, which can be difficult in species ...
Tamas Fülöp +3 more
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Tamas Fülöp +3 more
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Oncogene-induced Cellular Senescence
Advances in Anatomic Pathology, 2010Oncogene-induced senescence (OIS) is a robust and sustained antiproliferative response brought about by oncogenic signaling resulting from an activating mutation of an oncogene, or the inactivation of a tumor-suppressor gene. The pathways mediating OIS are complex and incompletely elucidated but, the proliferative arrest involves activation of both the
Chandeck, C., Mooi, W.J.
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