Results 261 to 270 of about 1,760,725 (298)
Some of the next articles are maybe not open access.
Hallmarks of Cellular Senescence
Trends in Cell Biology, 2018Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged organisms.
Alejandra, Hernandez-Segura +2 more
openaire +2 more sources
Genetics of cellular senescence
Mechanisms of Ageing and Development, 2002Cellular senescence or replicative senescence is a state of irreversible growth arrest that somatic cells enter as a result of replicative exhaustion. This can be mimicked by culture manipulations such as Ras oncogene overexpression or treatment with various agents such as sodium butyrate and 5-azacytidine.
Kaoru, Tominaga +3 more
openaire +2 more sources
Mechanisms of cellular senescence
Current Opinion in Genetics & Development, 1997Aging is a near universal process, yet the molecular mechanisms that underlie cellular senescence have remained elusive. Recent progress in determining the roles of various genetic influences in controlling the rate of cellular aging has made this an exciting time in aging research.
T, Smeal, L, Guarente
openaire +2 more sources
Cellular senescence and atherosclerosis
Medical Hypotheses, 1984Most recent texts on atherosclerosis do not consider cellular senescence. Texts that do take this up often emphasize smooth muscle cells. This paper presents some evidence for the role of cellular senescence in atherogenesis, and points out that the cells of the intimal endothelium may be equally important in this respect.
openaire +2 more sources
Current Opinion in Cell Biology, 1991
Differentiated eukaryotic cells have only a finite capacity for cell division. This limitation is thought to be a cellular manifestation of organismal aging, and a restraint to tumor progression. The molecular basis for cellular senescence is not known, but a molecular framework for understanding this phenomenon has recently been established.
A, McCormick, J, Campisi
openaire +2 more sources
Differentiated eukaryotic cells have only a finite capacity for cell division. This limitation is thought to be a cellular manifestation of organismal aging, and a restraint to tumor progression. The molecular basis for cellular senescence is not known, but a molecular framework for understanding this phenomenon has recently been established.
A, McCormick, J, Campisi
openaire +2 more sources
ING Proteins in Cellular Senescence
Current Drug Targets, 2009Cellular senescence is an effective anti-tumor barrier that acts by restraining the uncontrolled proliferation of cells carrying potentially oncogenic alterations. ING proteins are putative tumor suppressor proteins functionally linked to the p53 pathway and to chromatin regulation.
Menéndez, Camino +4 more
openaire +3 more sources
Markers of Cellular Senescence
2012Cellular senescence is a tumor suppression mechanism that evolved to limit duplication in somatic cells. Senescence is imposed by natural replicative boundaries or stress-induced signals, such as oncogenic transformation. Neoplastic cells can be forced to undergo senescence through genetic manipulations and epigenetic factors, including anticancer ...
openaire +2 more sources
Cellular senescence and PAPP-A
Growth Hormone & IGF ResearchCellular senescence and its accompanying secretome have major impact on growth and aging of mammalian organisms. A novel protease, PAPP-A, regulates the bioavailability of an important growth factor, insulin-like growth factor (IGF)-I, and has major impact on growth and aging.
openaire +2 more sources
2015
The term senescence was coined more than 50 years ago to describe the loss of replicative capacity of normal human diploid cells in culture.1 At that time, senescence was proposed to generally reflect the process of cellular aging.2., 3. Early studies also noted differences between the propensity of normal and malignant cells to senesce, with malignant
Bolden, Jessica E., Lowe, Scott W.
openaire +2 more sources
The term senescence was coined more than 50 years ago to describe the loss of replicative capacity of normal human diploid cells in culture.1 At that time, senescence was proposed to generally reflect the process of cellular aging.2., 3. Early studies also noted differences between the propensity of normal and malignant cells to senesce, with malignant
Bolden, Jessica E., Lowe, Scott W.
openaire +2 more sources
Cellular Senescence in Ageing: From Mechanisms to Therapeutic Opportunities
Nature Reviews Molecular Cell Biology, 2021Darren J Baker +2 more
exaly