Results 251 to 260 of about 1,760,725 (298)

Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers. [PDF]

MedComm (2020)
Cai G, Ren J, Wang L, Wu Y, Wang H, Cao X, Shang H, Hou X, Wang Y, Xue H, Dong T.   +10 more
europepmc   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Suppression of ATM kinase signaling accelerates cellular senescence. [PDF]

Stem Cell Reports
Ishikawa KI, Shiga T, Hirose T, Kuzumaki N, Miyoshi S, Yamaguchi A, Tamune H, Sarkar AK, Nakai K, Baba K, Okabe S, Hattori N, Okano H, Akamatsu W.   +13 more
europepmc   +1 more source

Cellular Senescence

Annals of Rejuvenation Science
openaire   +1 more source

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Cellular senescence in glioma

Journal of Neuro-Oncology, 2023
Glioma is the most common primary brain tumor and is often associated with treatment resistance and poor prognosis. Standard treatment typically involves radiotherapy and temozolomide-based chemotherapy, both of which induce cellular senescence-a tumor suppression mechanism.Gliomas employ various mechanisms to bypass or escape senescence and remain in ...
Rafał, Chojak, Jawad, Fares, Edgar, Petrosyan, Maciej S, Lesniak   +3 more
openaire   +2 more sources

Hypertension and cellular senescence

Biogerontology, 2023
Essential or primary hypertension is a wordwide health problem. Elevated blood pressure (BP) is closely associated not only with increased chronological aging but also with biological aging. There are various common pathways that play a role in cellular aging and BP regulation.
AFŞAR, Barış, Afsar, Rengin Elsurer
openaire   +3 more sources

Phosphate and Cellular Senescence

2022
Cellular senescence is one type of permeant arrest of cell growth and one of increasingly recognized contributor to aging and age-associated disease. High phosphate and low Klotho individually and synergistically lead to age-related degeneration in multiple organs.
Ming Chang, Hu, Orson W, Moe
openaire   +2 more sources

Cellular senescence in the cholangiopathies

Current Opinion in Gastroenterology, 2021
Purpose of review Cellular senescence (i.e. permanent withdrawal from the cell cycle) is increasingly recognized as a pathologic feature in a variety of inflammatory liver diseases, including primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC) and additional cholangiopathies.
Pamela S, Bogert, Steven P, O'Hara, Nicholas F, LaRusso   +2 more
openaire   +2 more sources

Cellular senescence and neurodegeneration

Human Genetics, 2023
Advancing age is a major risk factor of Alzheimer's disease (AD). The worldwide prevalence of AD is approximately 50 million people, and this number is projected to increase substantially. The molecular mechanisms underlying the aging-associated susceptibility to cognitive impairment in AD are largely unknown.
Kristopher Holloway, Kashfia Neherin, Kha Uyen Dam, Hong Zhang   +3 more
openaire   +2 more sources

Cellular Senescence and Ageing

2023
Cellular senescence has become a subject of great interest within the ageing research field over the last 60 years, from the first observation in vitro by Leonard Hayflick and Paul Moorhead in 1961, to novel findings of phenotypic sub-types and senescence-like phenotype in post-mitotic cells.
Reed R, Miwa S
openaire   +3 more sources