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Journal of Neuro-Oncology, 2023
Glioma is the most common primary brain tumor and is often associated with treatment resistance and poor prognosis. Standard treatment typically involves radiotherapy and temozolomide-based chemotherapy, both of which induce cellular senescence-a tumor suppression mechanism.Gliomas employ various mechanisms to bypass or escape senescence and remain in ...
Rafał, Chojak +3 more
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Glioma is the most common primary brain tumor and is often associated with treatment resistance and poor prognosis. Standard treatment typically involves radiotherapy and temozolomide-based chemotherapy, both of which induce cellular senescence-a tumor suppression mechanism.Gliomas employ various mechanisms to bypass or escape senescence and remain in ...
Rafał, Chojak +3 more
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Phosphate and Cellular Senescence
2022Cellular senescence is one type of permeant arrest of cell growth and one of increasingly recognized contributor to aging and age-associated disease. High phosphate and low Klotho individually and synergistically lead to age-related degeneration in multiple organs.
Ming Chang, Hu, Orson W, Moe
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Hypertension and cellular senescence
Biogerontology, 2023Essential or primary hypertension is a wordwide health problem. Elevated blood pressure (BP) is closely associated not only with increased chronological aging but also with biological aging. There are various common pathways that play a role in cellular aging and BP regulation.
AFŞAR, Barış, Afsar, Rengin Elsurer
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Cellular senescence in the cholangiopathies
Current Opinion in Gastroenterology, 2021Purpose of review Cellular senescence (i.e. permanent withdrawal from the cell cycle) is increasingly recognized as a pathologic feature in a variety of inflammatory liver diseases, including primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC) and additional cholangiopathies.
Pamela S, Bogert +2 more
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Cellular senescence and neurodegeneration
Human Genetics, 2023Advancing age is a major risk factor of Alzheimer's disease (AD). The worldwide prevalence of AD is approximately 50 million people, and this number is projected to increase substantially. The molecular mechanisms underlying the aging-associated susceptibility to cognitive impairment in AD are largely unknown.
Kristopher Holloway +3 more
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Cellular Senescence and Ageing
2023Cellular senescence has become a subject of great interest within the ageing research field over the last 60 years, from the first observation in vitro by Leonard Hayflick and Paul Moorhead in 1961, to novel findings of phenotypic sub-types and senescence-like phenotype in post-mitotic cells.
Reed R, Miwa S
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Hallmarks of Cellular Senescence
Trends in Cell Biology, 2018Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged organisms.
Alejandra, Hernandez-Segura +2 more
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Genetics of cellular senescence
Mechanisms of Ageing and Development, 2002Cellular senescence or replicative senescence is a state of irreversible growth arrest that somatic cells enter as a result of replicative exhaustion. This can be mimicked by culture manipulations such as Ras oncogene overexpression or treatment with various agents such as sodium butyrate and 5-azacytidine.
Kaoru, Tominaga +3 more
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Mechanisms of cellular senescence
Current Opinion in Genetics & Development, 1997Aging is a near universal process, yet the molecular mechanisms that underlie cellular senescence have remained elusive. Recent progress in determining the roles of various genetic influences in controlling the rate of cellular aging has made this an exciting time in aging research.
T, Smeal, L, Guarente
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Cellular senescence and atherosclerosis
Medical Hypotheses, 1984Most recent texts on atherosclerosis do not consider cellular senescence. Texts that do take this up often emphasize smooth muscle cells. This paper presents some evidence for the role of cellular senescence in atherogenesis, and points out that the cells of the intimal endothelium may be equally important in this respect.
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