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Genetics of cellular senescence
Mechanisms of Ageing and Development, 2002Cellular senescence or replicative senescence is a state of irreversible growth arrest that somatic cells enter as a result of replicative exhaustion. This can be mimicked by culture manipulations such as Ras oncogene overexpression or treatment with various agents such as sodium butyrate and 5-azacytidine.
Kaoru, Tominaga +3 more
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Abstract The molecular constituents of cells naturally deteriorate over time, raising the possibility of senescence in unicellular organisms analogous to the somatic aging that occurs in multicellular species. Studying this process requires a means for discriminating between parent and offspring cells, which can be difficult in species ...
Tamas Fülöp +3 more
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Tamas Fülöp +3 more
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Oncogene-induced Cellular Senescence
Advances in Anatomic Pathology, 2010Oncogene-induced senescence (OIS) is a robust and sustained antiproliferative response brought about by oncogenic signaling resulting from an activating mutation of an oncogene, or the inactivation of a tumor-suppressor gene. The pathways mediating OIS are complex and incompletely elucidated but, the proliferative arrest involves activation of both the
Chandeck, C., Mooi, W.J.
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Cellular Senescence and Ageing
2023Cellular senescence has become a subject of great interest within the ageing research field over the last 60 years, from the first observation in vitro by Leonard Hayflick and Paul Moorhead in 1961, to novel findings of phenotypic sub-types and senescence-like phenotype in post-mitotic cells.
Reed R, Miwa S
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Mechanisms of cellular senescence
Current Opinion in Genetics & Development, 1997Aging is a near universal process, yet the molecular mechanisms that underlie cellular senescence have remained elusive. Recent progress in determining the roles of various genetic influences in controlling the rate of cellular aging has made this an exciting time in aging research.
T, Smeal, L, Guarente
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Hallmarks of Cellular Senescence
Trends in Cell Biology, 2018Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged organisms.
Alejandra, Hernandez-Segura +2 more
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Cellular senescence and atherosclerosis
Medical Hypotheses, 1984Most recent texts on atherosclerosis do not consider cellular senescence. Texts that do take this up often emphasize smooth muscle cells. This paper presents some evidence for the role of cellular senescence in atherogenesis, and points out that the cells of the intimal endothelium may be equally important in this respect.
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Markers of Cellular Senescence
2012Cellular senescence is a tumor suppression mechanism that evolved to limit duplication in somatic cells. Senescence is imposed by natural replicative boundaries or stress-induced signals, such as oncogenic transformation. Neoplastic cells can be forced to undergo senescence through genetic manipulations and epigenetic factors, including anticancer ...
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Metabolomics in cancer research and emerging applications in clinical oncology
Ca-A Cancer Journal for Clinicians, 2021Daniel R Schmidt +2 more
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