Results 51 to 60 of about 1,861,216 (237)

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells [PDF]

, 2015
Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression.
Bröcker, E.-B., Haferkamp, S., Hufnagel, A.L., Kneitz, S., Leikam, C., Meierjohann, S., Murphy, D.J., Mühling, B., Nanda, I., Otto, C., Schartl, M., Schmid, M., Wagner, T.U.   +12 more
core   +2 more sources

Cellular Senescence and Ageing: Mechanisms and Interventions

Frontiers in Aging, 2022
The influence of the activation of a cellular phenotype termed senescence and it’s importance in ageing and age-related diseases is becoming more and more evident.
A. Mylonas, A. O’Loghlen
semanticscholar   +1 more source

Cellular senescence in normal physiology

Science
Long associated with aging, senescent cells can promote health and have physiological roles The aging of the world’s population has intensified interest in understanding the aging process and devising strategies and interventions to prolong a healthy ...
J. de Magalhães
semanticscholar   +1 more source

New insight into dyslipidemia‐induced cellular senescence in atherosclerosis

Biological Reviews of The Cambridge Philosophical Society, 2022
Atherosclerosis, characterized by lipid‐rich plaques in the arterial wall, is an age‐related disorder and a leading cause of mortality worldwide. However, the specific mechanisms remain complex.
Qun-yan Xiang, F. Tian, Jin Xu, Xiao Du, Shi-lan Zhang, Ling Liu   +5 more
semanticscholar   +1 more source

Cellular senescence in asthma: from pathogenesis to therapeutic challenges

EBioMedicine, 2023
Summary: Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the population worldwide. While cellular senescence is a normal physiological process, the accumulation of senescent cells is considered a trigger that transforms ...
Rongjun Wan, Prakhyath Srikaram, Vineeta Guntupalli, Chengping Hu, Qiong Chen, Peisong Gao   +5 more
doaj  

Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium

Frontiers in Cell and Developmental Biology, 2022
It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewal of
Tomoaki Hishida, Tomoaki Hishida, Eric Vazquez-Ferrer, Yuriko Hishida-Nozaki, Yuto Takemoto, Fumiyuki Hatanaka, Kei Yoshida, Javier Prieto, Sanjeeb Kumar Sahu, Yuta Takahashi, Pradeep Reddy, David D. O’Keefe, Concepcion Rodriguez Esteban, Paul S. Knoepfler, Estrella Nuñez Delicado, Antoni Castells, Josep M. Campistol, Ryuji Kato, Hiroshi Nakagawa, Hiroshi Nakagawa, Juan Carlos Izpisua Belmonte   +20 more
doaj   +1 more source

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome [PDF]

, 2019
Hutchinson–Gilford progeria syndrome (HGPS) is a genetic disorder characterized by premature aging features. Cells from HGPS patients express progerin, a truncated form of Lamin A, which perturbs cellular homeostasis leading to nuclear shape alterations,
Aguado J., Cancila V., d'Adda di Fagagna F., Dreesen O., Eriksson M., Jones-Weinert C. W., Lattanzi G., Ong P. F., Revechon G., Rossiello F., Sola-Carvajal A., Tripodo C., Wallen Arzt E.   +12 more
core   +1 more source

Epigenetic Regulation of Cellular Senescence

Cells, 2022
Senescence is a complex cellular stress response that abolishes proliferative capacity and generates a unique secretory pattern that is implicated in organismal aging and age-related disease.
Jack D. Crouch, M. Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Vladimir V. Botchkarev, Daniel S. Roh   +4 more
semanticscholar   +1 more source

The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]

, 2017
Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena, Dal Sasso, Eleonora, Forte, Maurizio, Frati, Giacomo, Gerosa, Gino, Iop, Laura, Palmerio, Silvia, Peruzzi, Mariangela, Schirone, Leonardo, Sciarretta, Sebastiano   +9 more
core   +4 more sources

Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence

Frontiers in Immunology, 2022
ObjectiveContinuous overactivation of the renal sympathetic nerve is considered to be an important cause of renal fibrosis. Accumulated senescent cells in the damaged kidney have metabolic activities and secrete amounts of proinflammatory factors as part
Qian Li, Yuanjun Deng, Lele Liu, Chunjiang Zhang, Yang Cai, Tianjing Zhang, Min Han, Gang Xu   +7 more
doaj   +1 more source