Results 41 to 50 of about 1,760,725 (298)

Cellular senescence in bone

Bone, 2019
Cellular senescence refers to a process induced by various types of stress that causes irreversible cell cycle arrest and distinct cellular alterations, including profound changes in gene expression, metabolism, and chromatin organization as well as activation/reinforcement of anti-apoptotic pathways and development of a pro-inflammatory secretome or ...
Joshua N. Farr, Sundeep Khosla
openaire   +3 more sources

Potential Role of Cellular Senescence in Asthma

Frontiers in Cell and Developmental Biology, 2020
Cellular senescence is a complicated process featured by irreversible cell cycle arrest and senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent cells, and low-grade inflammation.
Zhao-Ni Wang, Zhao-Ni Wang, Ruo-Nan Su, Bi-Yuan Yang, Ke-Xin Yang, Li-Fen Yang, Yan Yan, Yan Yan, Zhuang-Gui Chen   +8 more
doaj   +1 more source

17AAG Treatment Accelerates Doxorubicin Induced Cellular Senescence: Hsp90 Interferes with Enforced Senescence of Tumor Cells. [PDF]

, 2012
Contains fulltext : 110962.pdf (Publisher’s version ) (Open Access)Hsp90 chaperone has been identified as an attractive pharmacological target to combat cancer.
Sarangi, U., Kumar, J.U., Upasana Sarangi, Amere Subbarao Sreedhar, Paithankar, K.R., Khande Rao Paithankar, Jonnala Ujwal Kumar, Vaidyanathan Subramaniam, Sreedhar, A.S., Subramaniam, V.   +9 more
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Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration

Antioxidants, 2022
Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases.
Ryo Terao, Tazbir Ahmed, Ayana Suzumura, Hiroko Terasaki   +3 more
doaj   +1 more source

MicroRNA-Mediated Downregulation of HMGB2 Contributes to Cellular Senescence in Microvascular Endothelial Cells

, 2022
High mobility group box 2 (HMGB2) is a non-histone chromosomal protein involved in various biological processes, including cellular senescence. However, its role in cellular senescence has not been evaluated extensively.
Hye-Ram Jo, Jae-Hoon Jeong
core   +1 more source

Airway Epithelium Senescence as a Driving Mechanism in COPD Pathogenesis

Biomedicines, 2023
Cellular senescence is a state of permanent cell cycle arrest triggered by various intrinsic and extrinsic stressors. Cellular senescence results in impaired tissue repair and remodeling, loss of physiological integrity, organ dysfunction, and changes in
Georgia Bateman, Hong Guo-Parke, Aoife M. Rodgers, Dermot Linden, Melanie Bailey, Sinéad Weldon, Joseph C. Kidney, Clifford C. Taggart   +7 more
doaj   +1 more source

Senopathies—Diseases Associated with Cellular Senescence

, 2023
Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Markus Schosserer, Johannes Grillari, Oleh Lushchak   +2 more
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Cellular senescence: defining a path forward [PDF]

, 2019
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Thus, accurate detection of senescent cells, especially in vivo, is essential especially since the field of senotherapeutics is
Niedernhofer, L., Bennett, DC, Bischof O., Collado, M, Vougas, K., Maier, Andrea B., von Zglinicki, Thomas, Robbins, P.D., Adams, Peter D, Campisi, J., Alimonti, Andrea, Maier, Andrea, Jurk, D., Passos, João F., Hara E., Adams, P.D., Passos, João F, Bennett, Dorothy C., Maier, A. B., Niedernhofer, Laura J., Serrano, Manuel, Adams PD, Demaria, M., Campisi, J, Ferbeyre, G, Evangelou K, von Zglinicki, T., Collado M, Niedernhofer, Laura, Robbins, Paul D, Zhou, D., Campisi J., Demaria, Marco, von Zglinicki T, Zglinicki, Thomas von, Krizhanovsky V, Bishop, Cleo, Maier, AB, Serrano M, Adams, Peter D., Bishop, C., Hara E, Sedivy, J, Schmitt, C. A., Jurk, D, Gil, J, Niedernhofer, L, Passos, JF, Gil J, Gil, J., Gorgoulis, V., Robbins, PD, Sedivy J., Serrano M., Krizhanovsky, V, Bennett, D. C., Zhou D, Bishop C., Sedivy, J., Bischof O, Sedivy J, Demaria, M, Campisi, Judith, Ferbeyre, Gerardo, Gorgoulis, V, Niedernhofer L., Adams P. D., Narita M., Serrano, M., Bishop, C, Bishop C, Schmitt CA, Robbins, Paul, Passos, João, Hara, Eiji, Bennett, Dorothy C, Vougas, Konstantinos, Maier A. B., Vougas K, Evangelou, K, Bennett DC, Evangelou, Konstantinos, Ferbeyre, G., Maier, Andrea B, Gil J., Evangelou K., Bischof, O, Vougas K., Hara, E., Ferbeyre G., Robbins P. D., Adams, Peter, Demaria, Marco; id_orcid, Serrano, M, Krizhanovsky V., von Zglinicki T., Gil, Jesús, Jurk D., Maier, A.B., Bennett, D.C., Alimonti A., Bischof, O., Zhou, Daohong, Demaria M., Narita, Masashi, Krizhanovsky, V., Krizhanovsky, Valery, Schmitt, C.A., Passos, J. F., Passos J. F., Niedernhofer L, Ferberyre, G, Passos, J.F., Zhou, D, Robbins, P. D., Narita, M, Alimonti, A, Alimonti A, Sedivy, John, Evangelou, K., Campisi J, Collado, M., Maier AB, Maier, Andrea B.; id_orcid, Vougas, K, Collado M., Gorgoulis V, Collado, Manuel, Passos JF, Gorgoulis V., Schmitt, Clemens A, Narita, M., Robbins, Paul D., Schmitt, Clemens, Jurk, Diana, Schmitt C. A., Jurk D, Zhou, D. H., Ferbeyre G, von Zglinicki, T, Demaria M, Zhou D., Adams, P. D., Schmitt, Clemens A., Hara, E, Alimonti, A., Robbins PD, Gorgoulis, Vassilis, Adams, PD, Schmitt, CA, Bennett D. C., Bischof, Oliver, Narita M, Bennett, Dorothy, Collado Rodríguez, Manuel   +154 more
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Altered endocytosis in cellular senescence

, 2021
Cellular senescence occurs in response to diverse stresses (e.g., telomere shortening, DNA damage, oxidative stress, oncogene activation). A growing body of evidence indicates that alterations in multiple components of endocytic pathways contribute to ...
E G Kim, M A Schwartz, E Y Shin, Nak-Kyun Soung   +3 more
core   +1 more source

Role of hypoxia in cellular senescence

Pharmacological Research, 2023
Senescent cells persist and continuously secrete proinflammatory and tissue-remodeling molecules that poison surrounding cells, leading to various age-related diseases, including diabetes, atherosclerosis, and Alzheimer’s disease.
Haoyu Gao, Eugenie Nepovimova, Zbynek Heger, Marian Valko, Qinghua Wu, Kamil Kuca, Vojtech Adam   +6 more
doaj   +1 more source