Results 21 to 30 of about 239,802 (263)
A multidimensional systems biology analysis of cellular senescence in aging and disease
Genome Biology, 2020 Background Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases.
Roberto A. Avelar +15 more
doaj +1 more source
Central role of cellular senescence in TSLP-induced airway remodeling in asthma. [PDF]
PLoS ONE, 2013 BACKGROUND:Airway remodeling is a repair process that occurs after injury resulting in increased airway hyper-responsiveness in asthma. Thymic stromal lymphopoietin (TSLP), a vital cytokine, plays a critical role in orchestrating, perpetuating and ...
Jinxiang Wu +8 more
doaj +1 more source
Crosstalk between p53 modifiers at PML bodies
Molecular & Cellular Oncology, 2018 Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage.
Sonja Matt, Thomas G Hofmann
doaj +1 more source
EBioMedicine, 2019 Background: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases.
LaTonya J. Hickson +32 more
doaj +1 more source
Potential Role of Cellular Senescence in Asthma
Frontiers in Cell and Developmental Biology, 2020 Cellular senescence is a complicated process featured by irreversible cell cycle arrest and senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent cells, and low-grade inflammation.
Zhao-Ni Wang +8 more
doaj +1 more source
Airway Epithelium Senescence as a Driving Mechanism in COPD Pathogenesis
Biomedicines, 2023 Cellular senescence is a state of permanent cell cycle arrest triggered by various intrinsic and extrinsic stressors. Cellular senescence results in impaired tissue repair and remodeling, loss of physiological integrity, organ dysfunction, and changes in
Georgia Bateman +7 more
doaj +1 more source
Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration
Antioxidants, 2022 Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases.
Ryo Terao +3 more
doaj +1 more source
Role of hypoxia in cellular senescence
Pharmacological Research, 2023 Senescent cells persist and continuously secrete proinflammatory and tissue-remodeling molecules that poison surrounding cells, leading to various age-related diseases, including diabetes, atherosclerosis, and Alzheimer’s disease.
Haoyu Gao +6 more
doaj +1 more source
Cellular senescence and cancer [PDF]
The Journal of Pathology, 1999 The proliferative lifespan of normal mammalian cells is limited by intrinsic controls, which desensitize the cell-cycle machinery to extrinsic stimulation after a given number of cell divisions. One underlying clock driving this process of 'replicative senescence' is the progressive erosion of chromosome telomeres, which occurs with each round of DNA ...
openaire +2 more sources
Bone, 2019 Cellular senescence refers to a process induced by various types of stress that causes irreversible cell cycle arrest and distinct cellular alterations, including profound changes in gene expression, metabolism, and chromatin organization as well as activation/reinforcement of anti-apoptotic pathways and development of a pro-inflammatory secretome or ...
Joshua N. Farr, Sundeep Khosla
openaire +3 more sources