Results 21 to 30 of about 257,963 (311)
Frontiers in Physiology, 2021 Cellular senescence is a stable form of cell cycle arrest in response to various stressors. While it serves as an endogenous pro-resolving mechanism, detrimental effects ensue when it is dysregulated.
Xinghui Sun +3 more
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Annals of Medicine, 1992 The ageing of cells, cellular senescence, is an event that is encountered in all normal cells. Cells grown in vitro have a limited life span and do not grow well after a certain number of divisions. They cease to divide and eventually die. In accordance with this, the life expectancy of an established cell culture depends on the age of the donor. Cells
K, Koli, J, Keski-Oja
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Osteocyte Cellular Senescence [PDF]
Current Osteoporosis Reports, 2020 Senescent cells are now known to accumulate in multiple tissues with aging and through their inflammation (the senescence-associated secretory phenotype, SASP) contribute to aging and chronic diseases. Here, we review the roles of senescent osteocytes in the context of bone loss.Numerous studies have established that senescent osteocytes accumulate in ...
Joshua N. Farr +3 more
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Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases [PDF]
, 2023 Metastasis is a systemic condition and the major challenge among cancer types, as it can lead to multiorgan vulnerability. Recently, attention has been drawn to cellular senescence, a complex stress response condition, as a factor implicated in ...
Francesca Faggioli +2 more
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Cellular senescence: a hitchhiker's guide. [PDF]
, 2015 Since its first description over 50 years ago, cellular senescence has gained increasing attention. The number of research publications on cellular senescence last year alone is more than the number of publications in the decade in 1990s.
Aravinthan, Aloysious
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Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression [PDF]
, 2011 P>Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear immortal (proliferate indefinitely), while uncultured benign nevi (moles) show senescence markers ...
Marais, R. +40 more
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Aging, cellular Senescence, and progressive multiple sclerosis [PDF]
, 2020 Aging is one of the most important risk factors for the development of several neurodegenerative diseases including progressive multiple sclerosis (MS). Cellular senescence (CS) is a key biological process underlying aging.
Papadopoulos, Dimitrios +4 more
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A multidimensional systems biology analysis of cellular senescence in aging and disease
Genome Biology, 2020 Background Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases.
Roberto A. Avelar +15 more
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Changes in AMPK activity induces cellular senescence in human dental follicle cells
Experimental Gerontology, 2023 Dental Follicle Cells (DFCs) are somatic stem cells with a limited lifespan, but little is known about a possible mechanism of cellular senescence. Previous studies have shown that cellular senescence is associated with increased demand of glycolsis or ...
Christian Morsczeck +2 more
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Crosstalk between p53 modifiers at PML bodies
Molecular & Cellular Oncology, 2018 Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage.
Sonja Matt, Thomas G Hofmann
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