Results 21 to 30 of about 1,494,910 (255)

Potential Role of Cellular Senescence in Asthma

Frontiers in Cell and Developmental Biology, 2020
Cellular senescence is a complicated process featured by irreversible cell cycle arrest and senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent cells, and low-grade inflammation.
Zhao-Ni Wang, Zhao-Ni Wang, Ruo-Nan Su, Bi-Yuan Yang, Ke-Xin Yang, Li-Fen Yang, Yan Yan, Yan Yan, Zhuang-Gui Chen   +8 more
doaj   +1 more source

Senopathies—Diseases Associated with Cellular Senescence

, 2023
Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Markus Schosserer, Johannes Grillari, Oleh Lushchak   +2 more
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Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression [PDF]

, 2011
P>Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear immortal (proliferate indefinitely), while uncultured benign nevi (moles) show senescence markers ...
Marais, R., Marais, R, Bennett, DC, Julia K. Soo, Chow, J, Hill, L, Chow, J., Ross, ADM, W. Nicol Keith, MacKenzie Ross, A.D., Hossain, M., Bennett, D.C., Heung Chong, W, Hoare, S, Mehnaz Hossain, Soo, JK, Dorothy C. Bennett, Rebecca S. Collinson, Carla Milagre, Milagre, C., David M. Kallenberg, Lucy Hill, Collinson, RS, Mackenzie Ross, AD, Hill, L., Chong, WH, Richard Marais, Kallenberg, DM, Soo, J.K., Jade Chow, Keith, W.N., Hossain, M, Heung Chong, W., Hoare, S., Stacey Hoare, Kallenberg, D.M., Milagre, C, W. Heung Chong, Collinson, R.S., Keith, WN, Alastair D. MacKenzie Ross   +40 more
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Airway Epithelium Senescence as a Driving Mechanism in COPD Pathogenesis

Biomedicines, 2023
Cellular senescence is a state of permanent cell cycle arrest triggered by various intrinsic and extrinsic stressors. Cellular senescence results in impaired tissue repair and remodeling, loss of physiological integrity, organ dysfunction, and changes in
Georgia Bateman, Hong Guo-Parke, Aoife M. Rodgers, Dermot Linden, Melanie Bailey, Sinéad Weldon, Joseph C. Kidney, Clifford C. Taggart   +7 more
doaj   +1 more source

Epigenetic Regulation of Cellular Senescence

, 2022
Senescence is a complex cellular stress response that abolishes proliferative capacity and generates a unique secretory pattern that is implicated in organismal aging and age-related disease.
Jack Crouch, Daniel Roh, Rex Jeya Rajkumar Samdavid Thanapaul, Vladimir Botchkarev, Maria Shvedova   +4 more
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Role of hypoxia in cellular senescence

Pharmacological Research, 2023
Senescent cells persist and continuously secrete proinflammatory and tissue-remodeling molecules that poison surrounding cells, leading to various age-related diseases, including diabetes, atherosclerosis, and Alzheimer’s disease.
Haoyu Gao, Eugenie Nepovimova, Zbynek Heger, Marian Valko, Qinghua Wu, Kamil Kuca, Vojtech Adam   +6 more
doaj   +1 more source

Aging, cellular Senescence, and progressive multiple sclerosis [PDF]

, 2020
Aging is one of the most important risk factors for the development of several neurodegenerative diseases including progressive multiple sclerosis (MS). Cellular senescence (CS) is a key biological process underlying aging.
Papadopoulos, Dimitrios, Magliozzi, Roberta, Mitsikostas, Dimos D, Gorgoulis, Vassilis G, Nicholas, Richard S   +4 more
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The emerging role of cellular senescence in renal diseases [PDF]

, 2020
Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Francis, Heather, Meng, Fanyin, Xuesen Li, Zhou, Tianhao, Ping Zou, Glaser, Shannon, Siwen Li, Gianfranco Alpini, Rong Chen, Alpini, Gianfranco, Heather Francis, Zhou, Bingru, Fanyin Meng, Bingru Zhou, Nan Wu, Li, Xuesen, Tianhao Zhou, Wan, Ying, Li, Siwen, Zhang, Chunmei, Wu, Nan, Ying Wan, Chunmei Zhang, Zou, Ping, Chen, Rong, Shannon Glaser   +25 more
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Cellular senescence: a double-edged sword in cancer therapy

Frontiers in Oncology, 2023
Over the past few decades, cellular senescence has been identified in cancer patients undergoing chemotherapy and radiotherapy. Senescent cells are generally characterized by permanent cell cycle arrest as a response to endogenous and exogenous stresses.
Shuai Xiao, Dongmin Qin, Xueyang Hou, Lingli Tian, Yeping Yu, Rui Zhang, Rui Zhang, Hao Lyu, Dong Guo, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang   +11 more
doaj   +1 more source

MicroRNA-Mediated Downregulation of HMGB2 Contributes to Cellular Senescence in Microvascular Endothelial Cells

, 2022
High mobility group box 2 (HMGB2) is a non-histone chromosomal protein involved in various biological processes, including cellular senescence. However, its role in cellular senescence has not been evaluated extensively.
Hye-Ram Jo, Jae-Hoon Jeong
core   +1 more source