Results 11 to 20 of about 257,963 (311)
Current Biology, 2022 Cellular senescence defines a state of stable and generally irreversible proliferative arrest associated with various morphological, structural and functional changes (Figure 1), including enhanced expression and secretion of pro-inflammatory and tissue-remodelling mediators.
Varela-Eirín, Marta, Demaria, Marco
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On the evolution of cellular senescence [PDF]
Aging Cell, 2020 AbstractThe idea that senescent cells are causally involved in aging has gained strong support from findings that the removal of such cells alleviates many age‐related diseases and extends the life span of mice. While efforts proceed to make therapeutic use of such discoveries, it is important to ask what evolutionary forces might have been behind the ...
Axel Kowald +2 more
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Is “Cellular Senescence” a Misnomer?
GeroScience, 2022 One of the most striking findings in biogerontology in the 2010s was the demonstration that elimination of senescent cells delays many late-life diseases and extends lifespan in mice. This implied that accumulation of senescent cells promotes late-life diseases, particularly through action of senescent cell secretions (the senescence-associated ...
David Gems, Carina Kern
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Cellular Senescence in the Kidney [PDF]
Journal of the American Society of Nephrology, 2019 Senescent cells have undergone permanent growth arrest, adopt an altered secretory phenotype, and accumulate in the kidney and other organs with ageing and injury. Senescence has diverse physiologic roles and experimental studies support its importance in nephrogenesis, successful tissue repair, and in opposing malignant transformation. However, recent
Docherty, Marie-Helena +3 more
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Cellular Senescence in Adrenocortical Biology and Its Disorders [PDF]
, 2021 Cellular senescence is considered a physiological process along with aging and has recently been reported to be involved in the pathogenesis of many age-related disorders. Cellular senescence was first found in human fibroblasts and gradually explored in
Bin Liu +5 more
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Epigenetic Regulation of Cellular Senescence [PDF]
, 2022 Senescence is a complex cellular stress response that abolishes proliferative capacity and generates a unique secretory pattern that is implicated in organismal aging and age-related disease.
Jack Crouch +4 more
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Senopathies—Diseases Associated with Cellular Senescence [PDF]
, 2023 Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Markus Schosserer +2 more
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Cellular senescence in neuroblastoma
British Journal of Cancer, 2022 Neuroblastoma is a tumour that arises from the sympathoadrenal lineage occurring predominantly in children younger than five years. About half of the patients are diagnosed with high-risk tumours and undergo intensive multi-modal therapy. The success rate of current treatments for high-risk neuroblastoma is disappointingly low and survivors suffer from
Sofia Zanotti +5 more
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The Genetics of Cellular Senescence [PDF]
The American Journal of Human Genetics, 1998 the reversible quiescent state that some young cells undergo in the absence of growth factors. The role of replicative senescence in aging of the organism remains controversial, but correlative evidence suggests that it is an in vitro manifestation of an in vivo phenomenon.
Bérubé, Nathalie G. +2 more
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MicroRNA-Mediated Downregulation of HMGB2 Contributes to Cellular Senescence in Microvascular Endothelial Cells [PDF]
, 2022 High mobility group box 2 (HMGB2) is a non-histone chromosomal protein involved in various biological processes, including cellular senescence. However, its role in cellular senescence has not been evaluated extensively.
Hye-Ram Jo, Jae-Hoon Jeong
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