Results 11 to 20 of about 1,494,910 (255)

The effect of radiation on cellular ageing [PDF]

, 2012
This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel UniversityHumans are exposed to low and moderate doses of ionising radiation (IR) from a range of diagnostic and occupational sources which may lead to cellular ...
Sabin, Rebecca Jane
core   +6 more sources

Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities

Frontiers in Physiology, 2021
Cellular senescence is a stable form of cell cycle arrest in response to various stressors. While it serves as an endogenous pro-resolving mechanism, detrimental effects ensue when it is dysregulated.
Xinghui Sun, Xinghui Sun, Xinghui Sun, Mark W. Feinberg   +3 more
doaj   +1 more source

A multidimensional systems biology analysis of cellular senescence in aging and disease

Genome Biology, 2020
Background Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases.
Roberto A. Avelar, Javier Gómez Ortega, Robi Tacutu, Eleanor J. Tyler, Dominic Bennett, Paolo Binetti, Arie Budovsky, Kasit Chatsirisupachai, Emily Johnson, Alex Murray, Samuel Shields, Daniela Tejada-Martinez, Daniel Thornton, Vadim E. Fraifeld, Cleo L. Bishop, João Pedro de Magalhães   +15 more
doaj   +1 more source

Changes in AMPK activity induces cellular senescence in human dental follicle cells

Experimental Gerontology, 2023
Dental Follicle Cells (DFCs) are somatic stem cells with a limited lifespan, but little is known about a possible mechanism of cellular senescence. Previous studies have shown that cellular senescence is associated with increased demand of glycolsis or ...
Christian Morsczeck, Anja Reck, Torsten E. Reichert   +2 more
doaj   +1 more source

Crosstalk between p53 modifiers at PML bodies

Molecular & Cellular Oncology, 2018
Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage.
Sonja Matt, Thomas G Hofmann
doaj   +1 more source

Central role of cellular senescence in TSLP-induced airway remodeling in asthma. [PDF]

PLoS ONE, 2013
BACKGROUND:Airway remodeling is a repair process that occurs after injury resulting in increased airway hyper-responsiveness in asthma. Thymic stromal lymphopoietin (TSLP), a vital cytokine, plays a critical role in orchestrating, perpetuating and ...
Jinxiang Wu, Fangzheng Dong, Rui-An Wang, Junfei Wang, Jiping Zhao, Mengmeng Yang, Wenbin Gong, Rutao Cui, Liang Dong   +8 more
doaj   +1 more source

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney diseaseResearch in context

EBioMedicine, 2019
Background: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases.
LaTonya J. Hickson, Larissa G.P. Langhi Prata, Shane A. Bobart, Tamara K. Evans, Nino Giorgadze, Shahrukh K. Hashmi, Sandra M. Herrmann, Michael D. Jensen, Qingyi Jia, Kyra L. Jordan, Todd A. Kellogg, Sundeep Khosla, Daniel M. Koerber, Anthony B. Lagnado, Donna K. Lawson, Nathan K. LeBrasseur, Lilach O. Lerman, Kathleen M. McDonald, Travis J. McKenzie, João F. Passos, Robert J. Pignolo, Tamar Pirtskhalava, Ishran M. Saadiq, Kalli K. Schaefer, Stephen C. Textor, Stella G. Victorelli, Tammie L. Volkman, Ailing Xue, Mark A. Wentworth, Erin O. Wissler Gerdes, Yi Zhu, Tamara Tchkonia, James L. Kirkland   +32 more
doaj   +1 more source

microRNA in cellular senescence [PDF]

, 2010
Senescence is recognized as a permanent arrest of cell proliferation triggered by telomere shortening or various stresses. Senescence imposes a barrier to tumorigenesis and contributes to aging.
Sedia, Carla
core   +1 more source

Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration

Antioxidants, 2022
Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases.
Ryo Terao, Tazbir Ahmed, Ayana Suzumura, Hiroko Terasaki   +3 more
doaj   +1 more source

Cellular Senescence in Adrenocortical Biology and Its Disorders

, 2021
Cellular senescence is considered a physiological process along with aging and has recently been reported to be involved in the pathogenesis of many age-related disorders. Cellular senescence was first found in human fibroblasts and gradually explored in
Bin Liu, Xin Gao, Faping Li, Yuxiong Wang, Honglan Zhou, Yishu Wang   +5 more
core   +1 more source