Results 11 to 20 of about 357,990 (305)

Cellular senescence causes ageing [PDF]

Nature Reviews Molecular Cell Biology, 2019
Jesus Gil discusses the first evidence for cellular senescence being associated with ageing, and how these studies opened new routes for basic and translational research.
Jesus Gil
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Cellular senescence

Current Biology, 2022
Cellular senescence defines a state of stable and generally irreversible proliferative arrest associated with various morphological, structural and functional changes (Figure 1), including enhanced expression and secretion of pro-inflammatory and tissue-remodelling mediators.
Varela-Eirín, Marta, Demaria, Marco
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Osteocyte Cellular Senescence [PDF]

Current Osteoporosis Reports, 2020
Senescent cells are now known to accumulate in multiple tissues with aging and through their inflammation (the senescence-associated secretory phenotype, SASP) contribute to aging and chronic diseases. Here, we review the roles of senescent osteocytes in the context of bone loss.Numerous studies have established that senescent osteocytes accumulate in ...
Joshua N. Farr, Japneet Kaur, Madison L. Doolittle, Sundeep Khosla   +3 more
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High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone

Respiratory Research, 2022
Blood levels of the soluble receptor for advanced glycation end-products (sRAGE) are acutely elevated during the host inflammatory response to infection and predict mortality in COVID-19.
Lee Butcher, Jun-Cezar Zaldua, Jose A. Carnicero, Karl Hawkins, Janet Whitley, Rangaswamy Mothukuri, Phillip A. Evans, Keith Morris, Suresh Pillai, Jorge D. Erusalimsky   +9 more
doaj   +1 more source

Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence

Cell Death and Disease, 2022
During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression.
Paula Carpintero-Fernández, Michela Borghesan, Olga Eleftheriadou, Belen Pan-Castillo, Juan Antonio Fafián-Labora, Tom P. Mitchell, Alejandro Yuste, Muge Ogrunc, Thomas D. Nightingale, Maria Mayan, Ana O’Loghlen   +10 more
doaj   +1 more source

Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities

Frontiers in Physiology, 2021
Cellular senescence is a stable form of cell cycle arrest in response to various stressors. While it serves as an endogenous pro-resolving mechanism, detrimental effects ensue when it is dysregulated.
Xinghui Sun, Xinghui Sun, Xinghui Sun, Mark W. Feinberg   +3 more
doaj   +1 more source

Cellular Senescence

Cell, 2019
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly.
Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M   +25 more
  +7 more sources

Lysosome-mediated processing of chromatin in senescence [PDF]

, 2013
Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism, and a likely contributor to tissue aging. Cellular senescence involves extensive cellular remodeling, including of chromatin structure. Autophagy and lysosomes are
Adams, Adams-Cioaba, Andre Ivanov, Barnhill, Barradas, Bodnar, Braig, Bridger, Butin-Israeli, Cao, Chen, Chen, Coffinier, Collado, Cosme-Blanco, Dang, David M. Nelson, De Cecco, De Cecco, De Vos, Demidenko, Di Micco, Duncan, Feldser, Feser, Fraga, Freund, Funayama, Glatz, Goldman, Graeme Hewitt, Gray-Schopfer, Gray-Schopfer, Greer, Hayflick, Hong Wu, Houben, Howard, Hunt, Ichijima, Iglesias-Bartolome, Imai, Indrani Manoharan, Ishidoh, Jeff Pawlikowski, Joao F. Passos, John van Tuyn, Kanfi, Kang, Kennedy, Klionsky, Kreiling, Krizhanovsky, Krtolica, Kuilman, Lamark, Laszlo, Lee, Maures, McManus, Michaloglou, Michishita, Narita, Narita, Narita, Omholt, O’Sullivan, Pankiv, Parisha P. Shah, Passos, Peleg, Peter D. Adams, Pollock, Pospelova, Ruhoy, Sagiv, Santos-Rosa, Scaffidi, Serrano, Shelley L. Berger, Shimi, Shimi, Siebold, Smolle, Smolle, Soutoglou, Suram, Taranjit Singh Rai, Tran, Vargas, Vergnes, Viktor I. Korolchuk, Villeponteau, Wang, Wood, Xue, Yang, Young, Zhang, Zhang, Ziegler-Birling   +100 more
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Cellular Senescence

Annals of Medicine, 1992
The ageing of cells, cellular senescence, is an event that is encountered in all normal cells. Cells grown in vitro have a limited life span and do not grow well after a certain number of divisions. They cease to divide and eventually die. In accordance with this, the life expectancy of an established cell culture depends on the age of the donor. Cells
K, Koli, J, Keski-Oja
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Axonal growth arrests after an increased accumulation of Schwann cells expressing senescence markers and stromal cells in acellular nerve allografts [PDF]

, 2016
Acellular nerve allografts (ANAs) and other nerve constructs do not reliably facilitate axonal regeneration across long defects (>3 cm). Causes for this deficiency are poorly understood.
Ee, Xueping, Hoben, Gwendolyn M, Hunter, Daniel A, Mackinnon, Susan E, Moore, Amy M, Pan, Deng, Poppler, Louis H, Schellhardt, Lauren, Snyder-Warwick, Alison K, Stewart, Sheila A, Wood, Matthew D, Yan, Ying   +11 more
core   +2 more sources