Results 11 to 20 of about 1,760,725 (298)
Mitochondrial Homeostasis and Cellular Senescence [PDF]
Cells, 2019 Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and ...
Panagiotis V.S. Vasileiou +9 more
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The effect of radiation on cellular ageing [PDF]
, 2012 This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel UniversityHumans are exposed to low and moderate doses of ionising radiation (IR) from a range of diagnostic and occupational sources which may lead to cellular ...
Sabin, Rebecca Jane
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Current Biology, 2022 Cellular senescence defines a state of stable and generally irreversible proliferative arrest associated with various morphological, structural and functional changes (Figure 1), including enhanced expression and secretion of pro-inflammatory and tissue-remodelling mediators.
Varela-Eirín, Marta, Demaria, Marco
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On the evolution of cellular senescence [PDF]
Aging Cell, 2020 AbstractThe idea that senescent cells are causally involved in aging has gained strong support from findings that the removal of such cells alleviates many age‐related diseases and extends the life span of mice. While efforts proceed to make therapeutic use of such discoveries, it is important to ask what evolutionary forces might have been behind the ...
Axel Kowald +2 more
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Is “Cellular Senescence” a Misnomer?
GeroScience, 2022 One of the most striking findings in biogerontology in the 2010s was the demonstration that elimination of senescent cells delays many late-life diseases and extends lifespan in mice. This implied that accumulation of senescent cells promotes late-life diseases, particularly through action of senescent cell secretions (the senescence-associated ...
David Gems, Carina Kern
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Nature Communications, 2022 Ras mutations induce cell competition and cellular senescence to inhibit the proliferation of oncogenic mutated cells. Here the authors demonstrate that cellular senescence inhibits cell competition-induced elimination of oncogenic cells through HGF ...
Nanase Igarashi +12 more
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Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression
Nucleus, 2022 Cellular senescence provokes a dramatic alteration of chromatin organization and gene expression profile of proinflammatory factors, thereby contributing to various age-related pathologies via the senescence-associated secretory phenotype (SASP ...
Kenichi Miyata, Akiko Takahashi
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Telomere Maintenance and the cGAS-STING Pathway in Cancer
Cells, 2022 Cancer cells exhibit the unique characteristics of high proliferation and aberrant DNA damage response, which prevents cancer therapy from effectively eliminating them.
Hiroshi Ebata +2 more
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Cellular Senescence in the Kidney [PDF]
Journal of the American Society of Nephrology, 2019 Senescent cells have undergone permanent growth arrest, adopt an altered secretory phenotype, and accumulate in the kidney and other organs with ageing and injury. Senescence has diverse physiologic roles and experimental studies support its importance in nephrogenesis, successful tissue repair, and in opposing malignant transformation. However, recent
Docherty, Marie-Helena +3 more
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Communications Biology, 2022 Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related pathologies through the senescence-associated secretory phenotype (SASP).
Sho Sugawara +20 more
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