Results 11 to 20 of about 239,802 (263)

RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

Communications Biology, 2022
Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related pathologies through the senescence-associated secretory phenotype (SASP).
Sho Sugawara, Ryo Okada, Tze Mun Loo, Hisamichi Tanaka, Kenichi Miyata, Masatomo Chiba, Hiroko Kawasaki, Kaoru Katoh, Shizuo Kaji, Yoshiro Maezawa, Koutaro Yokote, Mizuho Nakayama, Masanobu Oshima, Koji Nagao, Chikashi Obuse, Satoshi Nagayama, Keiyo Takubo, Akira Nakanishi, Masato T. Kanemaki, Eiji Hara, Akiko Takahashi   +20 more
doaj   +1 more source

Cellular senescence in asthma: from pathogenesis to therapeutic challenges

EBioMedicine, 2023
Summary: Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the population worldwide. While cellular senescence is a normal physiological process, the accumulation of senescent cells is considered a trigger that transforms ...
Rongjun Wan, Prakhyath Srikaram, Vineeta Guntupalli, Chengping Hu, Qiong Chen, Peisong Gao   +5 more
doaj   +1 more source

High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone

Respiratory Research, 2022
Blood levels of the soluble receptor for advanced glycation end-products (sRAGE) are acutely elevated during the host inflammatory response to infection and predict mortality in COVID-19.
Lee Butcher, Jun-Cezar Zaldua, Jose A. Carnicero, Karl Hawkins, Janet Whitley, Rangaswamy Mothukuri, Phillip A. Evans, Keith Morris, Suresh Pillai, Jorge D. Erusalimsky   +9 more
doaj   +1 more source

The Genetics of Cellular Senescence [PDF]

The American Journal of Human Genetics, 1998
the reversible quiescent state that some young cells undergo in the absence of growth factors. The role of replicative senescence in aging of the organism remains controversial, but correlative evidence suggests that it is an in vitro manifestation of an in vivo phenomenon.
Bérubé, Nathalie G., Smith, James R., Pereira-Smith, Olivia M.   +2 more
openaire   +2 more sources

Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence

Cell Death and Disease, 2022
During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression.
Paula Carpintero-Fernández, Michela Borghesan, Olga Eleftheriadou, Belen Pan-Castillo, Juan Antonio Fafián-Labora, Tom P. Mitchell, Alejandro Yuste, Muge Ogrunc, Thomas D. Nightingale, Maria Mayan, Ana O’Loghlen   +10 more
doaj   +1 more source

Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities

Frontiers in Physiology, 2021
Cellular senescence is a stable form of cell cycle arrest in response to various stressors. While it serves as an endogenous pro-resolving mechanism, detrimental effects ensue when it is dysregulated.
Xinghui Sun, Xinghui Sun, Xinghui Sun, Mark W. Feinberg   +3 more
doaj   +1 more source

Cellular senescence in neuroblastoma

British Journal of Cancer, 2022
Neuroblastoma is a tumour that arises from the sympathoadrenal lineage occurring predominantly in children younger than five years. About half of the patients are diagnosed with high-risk tumours and undergo intensive multi-modal therapy. The success rate of current treatments for high-risk neuroblastoma is disappointingly low and survivors suffer from
Sofia Zanotti, Bieke Decaesteker, Suzanne Vanhauwaert, Bram De Wilde, Winnok H. De Vos, Frank Speleman   +5 more
openaire   +3 more sources

Cellular Senescence

Annals of Medicine, 1992
The ageing of cells, cellular senescence, is an event that is encountered in all normal cells. Cells grown in vitro have a limited life span and do not grow well after a certain number of divisions. They cease to divide and eventually die. In accordance with this, the life expectancy of an established cell culture depends on the age of the donor. Cells
K, Koli, J, Keski-Oja
openaire   +2 more sources

Osteocyte Cellular Senescence [PDF]

Current Osteoporosis Reports, 2020
Senescent cells are now known to accumulate in multiple tissues with aging and through their inflammation (the senescence-associated secretory phenotype, SASP) contribute to aging and chronic diseases. Here, we review the roles of senescent osteocytes in the context of bone loss.Numerous studies have established that senescent osteocytes accumulate in ...
Joshua N. Farr, Japneet Kaur, Madison L. Doolittle, Sundeep Khosla   +3 more
openaire   +2 more sources

Changes in AMPK activity induces cellular senescence in human dental follicle cells

Experimental Gerontology, 2023
Dental Follicle Cells (DFCs) are somatic stem cells with a limited lifespan, but little is known about a possible mechanism of cellular senescence. Previous studies have shown that cellular senescence is associated with increased demand of glycolsis or ...
Christian Morsczeck, Anja Reck, Torsten E. Reichert   +2 more
doaj   +1 more source