Results 31 to 40 of about 1,760,725 (298)
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Francis, Heather +25 more
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Epigenetic Regulation of Cellular Senescence
, 2022 Senescence is a complex cellular stress response that abolishes proliferative capacity and generates a unique secretory pattern that is implicated in organismal aging and age-related disease.
Jack Crouch +4 more
core +1 more source
Aging, cellular Senescence, and progressive multiple sclerosis [PDF]
, 2020 Aging is one of the most important risk factors for the development of several neurodegenerative diseases including progressive multiple sclerosis (MS). Cellular senescence (CS) is a key biological process underlying aging.
Papadopoulos, Dimitrios +4 more
core +1 more source
A multidimensional systems biology analysis of cellular senescence in aging and disease
Genome Biology, 2020 Background Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases.
Roberto A. Avelar +15 more
doaj +1 more source
Changes in AMPK activity induces cellular senescence in human dental follicle cells
Experimental Gerontology, 2023 Dental Follicle Cells (DFCs) are somatic stem cells with a limited lifespan, but little is known about a possible mechanism of cellular senescence. Previous studies have shown that cellular senescence is associated with increased demand of glycolsis or ...
Christian Morsczeck +2 more
doaj +1 more source
Crosstalk between p53 modifiers at PML bodies
Molecular & Cellular Oncology, 2018 Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage.
Sonja Matt, Thomas G Hofmann
doaj +1 more source
Central role of cellular senescence in TSLP-induced airway remodeling in asthma. [PDF]
PLoS ONE, 2013 BACKGROUND:Airway remodeling is a repair process that occurs after injury resulting in increased airway hyper-responsiveness in asthma. Thymic stromal lymphopoietin (TSLP), a vital cytokine, plays a critical role in orchestrating, perpetuating and ...
Jinxiang Wu +8 more
doaj +1 more source
EBioMedicine, 2019 Background: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases.
LaTonya J. Hickson +32 more
doaj +1 more source
microRNA in cellular senescence [PDF]
, 2010 Senescence is recognized as a permanent arrest of cell proliferation triggered by telomere shortening or various stresses. Senescence imposes a barrier to tumorigenesis and contributes to aging.
Sedia, Carla
core +1 more source
Molecular Mechanisms to Target Cellular Senescence in Aging and Disease [PDF]
, 2022 Cellular senescence is a state of irreversible cell cycle arrest in response to several stressors, including DNA damage, increased cellular oxidative stress, telomere shortening, oncogene activation, and a deep epigenetic remodeling [...
Beltrami A. P. +10 more
core +1 more source