Results 31 to 40 of about 257,963 (311)
Central role of cellular senescence in TSLP-induced airway remodeling in asthma. [PDF]
PLoS ONE, 2013 BACKGROUND:Airway remodeling is a repair process that occurs after injury resulting in increased airway hyper-responsiveness in asthma. Thymic stromal lymphopoietin (TSLP), a vital cytokine, plays a critical role in orchestrating, perpetuating and ...
Jinxiang Wu +8 more
doaj +1 more source
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Francis, Heather +25 more
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17AAG Treatment Accelerates Doxorubicin Induced Cellular Senescence: Hsp90 Interferes with Enforced Senescence of Tumor Cells. [PDF]
, 2012 Contains fulltext : 110962.pdf (Publisher’s version ) (Open Access)Hsp90 chaperone has been identified as an attractive pharmacological target to combat cancer.
Sarangi, U. +9 more
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タバコ煙成分で培養したヒト歯根膜線維芽細胞の伸展刺激による細胞老化の増悪化 [PDF]
, 2023 大阪歯科大学Osaka Dental University博士（歯学）Understanding the effect of smoking on oral pathologies at the molecular and cellular level is required for the stable progress of oral medicine.
Zhao, Ming, チョウ, メイ, 趙, 明
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EBioMedicine, 2019 Background: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases.
LaTonya J. Hickson +32 more
doaj +1 more source
Insights from In Vivo Studies of Cellular Senescence [PDF]
, 2020 Cellular senescence is the dynamic process of durable cell-cycle arrest. Senescent cells remain metabolically active and often acquire a distinctive bioactive secretory phenotype.
Luis I. Prieto +2 more
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Potential Role of Cellular Senescence in Asthma
Frontiers in Cell and Developmental Biology, 2020 Cellular senescence is a complicated process featured by irreversible cell cycle arrest and senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent cells, and low-grade inflammation.
Zhao-Ni Wang +8 more
doaj +1 more source
Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration
Antioxidants, 2022 Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases.
Ryo Terao +3 more
doaj +1 more source
Senescence Alterations in Pulmonary Hypertension [PDF]
, 2021 Cellular senescence is the arrest of normal cell division and is commonly associated with aging. The interest in the role of cellular senescence in lung diseases derives from the observation of markers of senescence in chronic obstructive pulmonary ...
Julio Cortijo +3 more
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Bone, 2019 Cellular senescence refers to a process induced by various types of stress that causes irreversible cell cycle arrest and distinct cellular alterations, including profound changes in gene expression, metabolism, and chromatin organization as well as activation/reinforcement of anti-apoptotic pathways and development of a pro-inflammatory secretome or ...
Joshua N. Farr, Sundeep Khosla
openaire +3 more sources