Results 51 to 60 of about 1,760,725 (298)

Senescence and Cellular Immortality

, 2017
Cellular senescence is a state of irreversible growth arrest activated by a number of oncogenic signals. The senescence program prevents tumorigenesis via both cell and non-cell autonomous mechanisms. However, senescent cells accumulate and persist in the body during aging or following elevated genotoxic stress.
Demaria, Marco, Velarde, Michael C.
openaire   +1 more source

Cellular senescence and cancer [PDF]

The Journal of Pathology, 1999
The proliferative lifespan of normal mammalian cells is limited by intrinsic controls, which desensitize the cell-cycle machinery to extrinsic stimulation after a given number of cell divisions. One underlying clock driving this process of 'replicative senescence' is the progressive erosion of chromosome telomeres, which occurs with each round of DNA ...
openaire   +2 more sources

Cellular senescence: unravelling complexity [PDF]

AGE, 2009
Cellular senescence might be a tumour suppressing mechanism as well as a contributor to age-related loss of tissue function. It has been characterised classically as the result of the loss of DNA sequences called telomeres at the end of chromosomes. However, recent studies have revealed that senescence is in fact an intricate process, involving the ...
João F, Passos, Cedric, Simillion, Jennifer, Hallinan, Anil, Wipat, Thomas, von Zglinicki   +4 more
openaire   +2 more sources

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression [PDF]

, 2011
P>Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear immortal (proliferate indefinitely), while uncultured benign nevi (moles) show senescence markers ...
Marais, R., Marais, R, Bennett, DC, Julia K. Soo, Chow, J, Hill, L, Chow, J., Ross, ADM, W. Nicol Keith, MacKenzie Ross, A.D., Hossain, M., Bennett, D.C., Heung Chong, W, Hoare, S, Mehnaz Hossain, Soo, JK, Dorothy C. Bennett, Rebecca S. Collinson, Carla Milagre, Milagre, C., David M. Kallenberg, Lucy Hill, Collinson, RS, Mackenzie Ross, AD, Hill, L., Chong, WH, Richard Marais, Kallenberg, DM, Soo, J.K., Jade Chow, Keith, W.N., Hossain, M, Heung Chong, W., Hoare, S., Stacey Hoare, Kallenberg, D.M., Milagre, C, W. Heung Chong, Collinson, R.S., Keith, WN, Alastair D. MacKenzie Ross   +40 more
core   +1 more source

p16INK4a in cellular senescence

Aging, 2013
A crucial mechanism in the establishment of cellular senescence is the activation of the INK4/ARF locus, which is epigenetically regulated and under tight control of the Polycomb group (PcG) Trithorax group (TrxG) proteins [1]. In proliferating cells, the locus is silenced by Polycomb repressive complexes (PRCs), and the chromatin is enriched in ...
Elisabeth, Simboeck, Luciano, Di Croce
openaire   +2 more sources

Cellular senescence: a double-edged sword in cancer therapy

Frontiers in Oncology, 2023
Over the past few decades, cellular senescence has been identified in cancer patients undergoing chemotherapy and radiotherapy. Senescent cells are generally characterized by permanent cell cycle arrest as a response to endogenous and exogenous stresses.
Shuai Xiao, Dongmin Qin, Xueyang Hou, Lingli Tian, Yeping Yu, Rui Zhang, Rui Zhang, Hao Lyu, Dong Guo, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang   +11 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Camellia japonica Seed Oil Fermented by Sporidiobolus pararoseus Prevents Skin Cellular Photoaging by Inducing Autophagy

Life
Camellia japonica L. (Theaceae) seed oil is an essential component for skin protection, attributed to its antioxidant properties and anti-aging effects. In this study, Camellia japonica seed oil underwent fermentation with Sporidiobolus pararoseus (Fell &
Bai Lv, Jiale Meng, Xichao Zhang, Guangtao Li, Hongqi Gao, Yi Jiang, Zhanwei Zhou, Gang Chen   +7 more
doaj   +1 more source