Results 61 to 70 of about 1,861,365 (381)
Cellular senescence and cancer [PDF]
The Journal of Pathology, 1999 The proliferative lifespan of normal mammalian cells is limited by intrinsic controls, which desensitize the cell-cycle machinery to extrinsic stimulation after a given number of cell divisions. One underlying clock driving this process of 'replicative senescence' is the progressive erosion of chromosome telomeres, which occurs with each round of DNA ...
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BMB Reports, 2019 Cellular senescence, a process of cell proliferation arrest in response to various stressors, has been considered to be important factor in age-related disease. Identification of senescent cells in tissues is limited and the role of senescent cells is poorly understood. Recently however, several studies showed the characterization of senescent cells in
Young Hwa Kim, Tae Jun Park
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Aging, cellular senescence, and cancer.
Annual Review of Physiology, 2013 For most species, aging promotes a host of degenerative pathologies that are characterized by debilitating losses of tissue or cellular function. However, especially among vertebrates, aging also promotes hyperplastic pathologies, the most deadly of ...
J. Campisi
semanticscholar +1 more source
Cellular Senescence in Cardiovascular Diseases: A Systematic Review
Aging and Disease, 2022 Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of death around the world. Recently, cellular senescence has received potential attention as a promising target in preventing cardiovascular diseases, including ...
Can Hu +4 more
semanticscholar +1 more source
A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours [PDF]
, 2015 Enhancement of cellular senescence in tumours triggers a stable cell growth arrest and activation of an antitumour immune response that can be exploited for cancer therapy.
Alajati, Abdullah +25 more
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Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link? [PDF]
, 2020 Telomeres are higher order structures that cap and protect chromosome ends. Telomeric DNA naturally shortens during somatic cell division and as a result of oxidative stress.
Erusalimsky, Jorge
core +1 more source
Therapeutic targeting of replicative immortality [PDF]
, 2015 One of the hallmarks of malignant cell populations is the ability to undergo continuous proliferation. This property allows clonal lineages to acquire sequential aberrations that can fuel increasingly autonomous growth, invasiveness, and therapeutic ...
Amedei, Amedeo +29 more
core +2 more sources
A guide to assessing cellular senescence in vitro and in vivo
The FEBS Journal, 2020 Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a stable cell cycle arrest upon damage or stress and elicits a secretory phenotype.
Estela González-Gualda +3 more
semanticscholar +1 more source
The role of cellular senescence and SASP in tumour microenvironment
The FEBS Journal, 2022 Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by various cellular stresses and is known to play a pivotal role in tumour suppression. While senescence‐associated growth arrest can inhibit the proliferation of
M. Takasugi +3 more
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Cellular senescence and the tumour microenvironment
Molecular Oncology, 2022 The senescence‐associated secretory phenotype (SASP), where senescent cells produce a variety of secreted proteins including inflammatory cytokines, chemokines, matrix remodelling factors, growth factors and so on, plays pivotal but varying roles in the ...
M. Takasugi, Y. Yoshida, Naoko Ohtani
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