Results 1 to 10 of about 1,057,849 (262)

Enhanced cellular therapy: revolutionizing adoptive cellular therapy. [PDF]

Exp Hematol Oncol
AbstractEnhanced cellular therapy has emerged as a novel concept following the basis of cellular therapy. This treatment modality applied drugs or biotechnology to directly enhance or genetically modify cells to enhance the efficacy of adoptive cellular therapy (ACT).
Xu MY, Zeng N, Liu CQ, Sun JX, An Y, Zhang SH, Xu JZ, Zhong XY, Ma SY, He HD, Hu J, Xia QD, Wang SG.   +12 more
europepmc   +4 more sources

Enalaprilat and losartan decrease erythroid precursors frequency in cells from patients with polycythemia vera

Hematology, 2023
Objective: Polycythemia Vera (PV) is a myeloproliferative neoplasm characterized by the overproduction of red blood cells. First-line therapies are directed at lowering hematocrit levels. After the discovery of a mutation in the Janus kinase 2 (JAK2V617F)
Angela Bozza, Martina Bernardi, Daniela Catanzaro, Katia Chieregato, Anna Merlo, Giuseppe Astori   +5 more
doaj   +1 more source

Mimicking Myelodysplastic Syndrome: Importance of Differential Diagnosis

Case Reports in Hematology, 2021
Copper deficiency is a rare nutritional deficiency with hematological manifestations that mimic those found in myelodysplastic syndrome, a hematological malignancy incurable without allogeneic hematopoietic stem cell transplantation.
Thomas Luo, Joanna Zurko, John Astle, Nirav N. Shah   +3 more
doaj   +1 more source

Improved outcomes of high-risk relapsed Hodgkin lymphoma patients after high-dose chemotherapy: a 15-year analysis

Haematologica, 2021
High-dose chemotherapy and autologous stem-cell transplant (HDC/ASCT) is standard treatment for chemosensitive relapsed classical Hodgkin lymphoma, although outcomes of high-risk relapse (HRR) patients remain suboptimal.
Yago Nieto, Stephen Gruschkus, Benigno C. Valdez, Roy B. Jones, Paolo Anderlini, Chitra Hosing, Uday Popat, Muzaffar Qazilbash, Partow Kebriaei, Amin Alousi, Neeraj Saini, Samer Srour, Katayoun Rezvani, Jeremy Ramdial, Melissa Barnett, Alison Gulbis, Terri Lynn Shigle, Sairah Ahmed, Swaminathan Iyer, Hun Lee, Ranjit Nair, Simrit Parmar, Raphael Steiner, Bouthaina Dabaja, Chelsea Pinnix, Jillian Gunther, Branko Cuglievan, Kris Mahadeo, Sajad Khazal, Hubert Chuang, Richard Champlin, Elizabeth J. Shpall, Borje S. Andersson   +32 more
doaj   +1 more source

In Vitro FVIII-Encoding Transgenic Mesenchymal Stem Cells Maintain Successful Coagulation in FVIII-Deficient Plasma Mimicking Hemophilia A

Turkish Journal of Hematology, 2023
Objective: Hemophilia A is an X-linked recessive bleeding disorder caused by a deficiency of plasma coagulation factor VIII (FVIII), and it accounts for about 80%-85% of all cases of hemophilia.
Cansu Hemşinlioğlu, Elif Sibel Aslan, Cihan Tastan, Didem Çakırsoy, Raife Dilek Turan, Utku Seyis, Muhammer Elek, Gözde Sır Karakuş, Ömür Selin Günaydın, Selen Abanuz, Derya Dilek Kançağı, Bulut Yurtsever, Koray Yalçın, Murat Kasap, Ercüment Ovalı   +14 more
doaj   +1 more source

Preclinical Evaluation of the Tumorigenic and Immunomodulatory Properties of Human Bone Marrow Mesenchymal Stromal Cell Populations with Clonal Trisomy 5

Stem Cells International, 2022
Cytogenetic aberrations may emerge in human mesenchymal stromal cells (MSC) during ex vivo expansion for cell therapy. We have detected clonal trisomy 5 in two distinct autologous MSC products expanded from bone marrow which, based on the current quality
Maria Susana Joya Marodin, Juliana A. Godoy, Raquel M. Alves-Paiva, Kelen Alvarez, Thiago Giove Mitsugi, Ana Cristina Victorino Krepischi, Nelson Hamerschlak, Maria Augusta Tezelli Bortolini, Rodrigo Castro, Andrea T. Kondo, Jose Mauro Kutner, Oswaldo Keith Okamoto   +11 more
doaj   +1 more source

Cellular metabolism therapy

Journal of Translational Medicine, 2022
No abstract ...
openaire   +4 more sources

Preclinical efficacy and safety analysis of gamma-irradiated inactivated SARS-CoV-2 vaccine candidates

Scientific Reports, 2021
COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, SARS-CoV-2 vaccines have become crucial for reducing morbidity and mortality.
Gozde Sir Karakus, Cihan Tastan, Derya Dilek Kancagi, Bulut Yurtsever, Gamze Tumentemur, Sevda Demir, Raife Dilek Turan, Selen Abanuz, Didem Cakirsoy, Utku Seyis, Samed Ozer, Omer Elibol, Muhammer Elek, Gurcan Ertop, Serap Arbak, Merve Acikel Elmas, Cansu Hemsinlioglu, Ayse Sesin Kocagoz, Ozden Hatirnaz Ng, Sezer Akyoney, Ilayda Sahin, Ugur Ozbek, Dilek Telci, Fikrettin Sahin, Koray Yalcin, Siret Ratip, Ercument Ovali   +26 more
doaj   +1 more source

How CAR T Cells Breathe

Cells, 2022
The manufacture of efficacious CAR T cells represents a major challenge in cellular therapy. An important aspect of their quality concerns energy production and consumption, known as metabolism.
Christopher Forcados, Sandy Joaquina, Nicholas Paul Casey, Benjamin Caulier, Sébastien Wälchli   +4 more
doaj   +1 more source

Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice

Stem Cell Research & Therapy, 2017
Background Radiation exposure poses a significant threat to public health. Hematopoietic injury is one of the major manifestations of acute radiation sickness.
Pasupathi Sundaramoorthy, Qinhong Wang, Zhihong Zheng, Yiqun Jiao, Benny J. Chen, Phuong L. Doan, Nelson J. Chao, Yubin Kang   +7 more
doaj   +1 more source