Bioactive Cembranoid Composition in the Soft Coral of Sarcophyton glaccum on The Response to Changing pH [PDF]
Ilmu Kelautan, 2017 Soft coral is predicted to outcompete with hard coral in future ocean acidification scenarios. Beside the biological resilience shown in acidic conditions, soft corals ability to maintain or compete for space is shown to relate with their ability to ...
Hedi Indra Januar +3 more
doaj +12 more sources
Pharmacokinetics and Metabolism of 4R-Cembranoid. [PDF]
PLoS ONE, 2015 4R-cembranoid (4R) is a natural cyclic diterpenoid found in tobacco leaves that displays neuroprotective activity. 4R protects against NMDA, paraoxon (POX), and diisopropylfluorophosphate (DFP) damage in rat hippocampal slices and against DFP in rats in ...
Wanda Vélez-Carrasco +6 more
doaj +6 more sources
Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis [PDF]
Marine Drugs, 2018 Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (6–14), were isolated from the soft coral Sinularia flexibilis ...
Chiung-Yao Huang +2 more
exaly +4 more sources
Synthesis and Evaluation of a 2,11‐Cembranoid‐Inspired Library [PDF]
Chemistry – A European Journal, 2016 AbstractThe 2,11‐cembranoid family of natural products has been used as inspiration for the synthesis of a structurally simplified, functionally diverse library of octahydroisobenzofuran‐based compounds designed to augment a typical medicinal chemistry library screen. Ring‐closing metathesis, lactonisation and SmI2‐mediated methods were exemplified and
Welford, AJ +11 more
openaire +5 more sources
4R-cembranoid suppresses glial cells inflammatory phenotypes and prevents hippocampal neuronal loss in LPS-treated mice. [PDF]
J Neurosci Res4R‐cembranoid is a natural compound that protects neurons against LPS‐induced neuroinflammation by reducing the number of pro‐inflammatory microglia and by promoting the secretion of astrocytic neuroprotective factors in the mice hippocampus. Abstract Chronic neuroinflammation has been implicated in neurodegenerative disease pathogenesis. A key feature
Rojas-Colón LA +4 more
europepmc +4 more sources
Formation of α- and β-Cembratriene-Diols in Tobacco (Nicotiana tabacum L.) Is Regulated by Jasmonate-Signaling Components via Manipulating Multiple Cembranoid Synthetic Genes [PDF]
Molecules, 2018 Cembranoids are a group of natural diterpenoid compounds with pharmaceutical potentials, and the cembratriene-diols produced by Nicotiana (tobacco) species display activities in anti-nicotine addiction and neuron protection.
Jinkai Sui +12 more
doaj +2 more sources
Exploring the catalytic cascade of cembranoid biosynthesis by combination of genetic engineering and molecular simulations [PDF]
Computational and Structural Biotechnology Journal, 2020 While chemical steps involved in bioactive cembranoid biosynthesis have been examined, the corresponding enzymatic mechanisms leading to their formation remain elusive.
Patrick Schrepfer +5 more
doaj +2 more sources
Cembranoids Content of Soft Coral Sarcophyton from Acidified Environment at Volcano Island, Indonesia [PDF]
Squalen, 2017 Cembranoid content in soft coral is known as a chemotype that relate with genotype and environment. This research aimed to characterize the cembranoid Sarcophyton soft coral from the reef that acidified by CO2 volcanic vents (pHT 7.8) at Volcano Islands ...
Hedi Indra Januar +3 more
doaj +3 more sources
A Brief Review on New Naturally Occurring Cembranoid Diterpene Derivatives from the Soft Corals of the Genera Sarcophyton, Sinularia, and Lobophytum Since 2016 [PDF]
Molecules, 2019 This work reviews the new isolated cembranoid derivatives from species of the genera Sarcophyton, Sinularia, and Lobophytum as well as their biological properties, during 2016⁻2018.
Inna Glibka Rodrigues +2 more
doaj +3 more sources
Marine cembranoid synthesis [PDF]
Tetrahedron Letters, 1989 Abstract trans , trans -Farnesol can be converted to a versatile precursor for the synthesis of C-3,C-4 oxygenated marine cembranoids.
Marcus A. Tius, Jean M. Cullingham
openaire +2 more sources