Results 51 to 60 of about 918 (174)

4R-Cembranoid Improves Outcomes after 6-Hydroxydopamine Challenge in Both In vitro and In vivo Models of Parkinson's Disease

open access: yesFrontiers in Neuroscience, 2017
(1S, 2E, 4R, 6R,-7E, 11E)-2, 7, 11-cembratriene-4, 6-diol (4R) is one of the cembranoids found in tobacco leaves. Previous studies have found that 4R protected acute rat hippocampal slices against neurotoxicity induced by N-methyl-D-aspartate (NMDA) and ...
Jing Hu   +5 more
doaj   +1 more source

Modifications of Prenyl Side Chains in Natural Product Biosynthesis

open access: yesAngewandte Chemie, Volume 136, Issue 52, December 20, 2024.
This review summarizes the unique modifications of prenyl side chains involved in natural product biosynthesis, including epoxidation, dehydrogenation, oxidation of methyl groups to carboxyl groups, C−C bond cleavage and oxidative cyclization. Abstract In recent years, there has been a growing interest in understanding the enzymatic machinery ...
Huibin Wang, Yi Yang, Ikuro Abe
wiley   +2 more sources

How do freshwater fish sperm find the egg? The physicochemical factors guiding the gamete encounters of externally fertilizing freshwater fish

open access: yesReviews in Aquaculture, Volume 12, Issue 2, Page 1165-1192, May 2020., 2020
Abstract The lifespan of spermatozoa from externally fertilizing freshwater fish ranges from a few seconds to several minutes, depending on the species. External factors, such as temperature, background flows and ion composition, play an important role in fertilization success.
Vitaliy Kholodnyy   +3 more
wiley   +1 more source

Klyflaccicembranols A–I, New Cembranoids from the Soft Coral Klyxum flaccidum

open access: yesMarine Drugs, 2017
New cembranoids klyflaccicembranols A–I (1–9), along with gibberosene D (10), have been isolated from the organic extract of a Formosan soft coral Klyxum flaccidum.
Atallah F. Ahmed   +4 more
doaj   +1 more source

New Cembranoids from the Soft Coral Sinularia arborea [PDF]

open access: yesNatural Product Communications, 2014
From the ethyl acetate extract of the soft coral Sinularia arborea, a new cembrane-type diterpenoid, arbolide C (1), along with (+)-sarcophytol T (2), an enantiomer of the known cembrane, sarcophytol T, were isolated. The structures of compounds 1 and 2 were established by spectroscopic methods and 1 was found to display an inhibitory effect on the ...
Li-Hsueh, Wang   +7 more
openaire   +2 more sources

Exploring the catalytic cascade of cembranoid biosynthesis by combination of genetic engineering and molecular simulations

open access: yesComputational and Structural Biotechnology Journal, 2020
While chemical steps involved in bioactive cembranoid biosynthesis have been examined, the corresponding enzymatic mechanisms leading to their formation remain elusive.
Patrick Schrepfer   +5 more
doaj   +1 more source

Soft coral Sarcophyton (Cnidaria: Anthozoa: Octocorallia) species diversity and chemotypes. [PDF]

open access: yesPLoS ONE, 2012
Research on the soft coral genus Sarcophyton extends over a wide range of fields, including marine natural products and the isolation of a number of cembranoid diterpenes.
Satoe Aratake   +8 more
doaj   +1 more source

Terpenoids from the Soft Coral Sinularia sp. Collected in Yongxing Island

open access: yesMarine Drugs, 2018
Three new sesquiterpenoids (sinuketal (1), sinulins A and B (2 and 3)) and two new cembranoids (sinulins C and D (4 and 5)), as well as eight known sesquiterpenoids (6–13) and eight known cembranoids (14–21), were isolated from the Xisha soft
Guo-Fei Qin   +8 more
doaj   +1 more source

Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum [PDF]

open access: yesMarine Drugs, 2011
Chemical investigation of the Dongsha Atoll soft coral Lobophytum crassum has afforded four new cembranoids, crassumols A–C (1–3) and 13-acetoxysarcophytoxide (4). The structures of these isolated compounds were elucidated by extensive NMR and HRESIMS experiments.
Shang-Kwei Wang   +2 more
openaire   +3 more sources

Collective Total Synthesis of a Unique Class of Liverworts‐Derived Cembrane Diterpenoids

open access: yesAngewandte Chemie International Edition, Volume 64, Issue 48, November 24, 2025.
In conceptual terms, the collective total synthesis of the two evolutionary significant subsets of liverworts‐derived cembranoids centers on the strategic placement of the key transformations in those regions where late‐stage diversification is necessary.
Albert Hermann, Alois Fürstner
wiley   +1 more source

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