Results 31 to 40 of about 1,430 (181)

New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinum [PDF]

, 2020
Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity.
Elena Talero, Héctor M. Guzmán, Javier Ávila-Román, José Félix Gómez-Reyes, Marcelino Gutiérrez, Ricardo Santamaría, Virginia Motilva   +6 more
core   +1 more source

Methyl jasmonate‐dependent hydrogen sulfide mediates melatonin‐induced aphid resistance of watermelon

Food and Energy Security, Volume 12, Issue 5, September 2023., 2023
Abstract As one of the most destructive pests, aphids cause significant damage on various agricultural and horticultural crops. Recently, melatonin has been shown to enhance plant resistance to aphids; however, the underlying mechanisms remain unclear.
Zhuangzhuang Su, Zhixiang Lan, Yufan Gao, Yunfei Liu, Jian Shen, Yanliang Guo, Jianxiang Ma, Yong Zhang, Feishi Luan, Xian Zhang, Hao Li   +10 more
wiley   +1 more source

Exploration of anti‐leukemic effect of soft coral‐derived 13‐acetoxysarcocrassolide: Induction of apoptosis via oxidative stress as a potent inhibitor of heat shock protein 90 and topoisomerase II

The Kaohsiung Journal of Medical Sciences, Volume 39, Issue 7, Page 718-731, July 2023., 2023
Abstract 13‐Acetoxysarcocrassolide (13‐AC) is a marine cembranoid derived from the aquaculture soft coral of Lobophytum crassum. The cytotoxic effect of 13‐AC against leukemia cells was previously reported but its mechanism of action is still unexplored.
Hsien‐Kuo Chin, Mei‐Chin Lu, Kai‐Cheng Hsu, Mohamed El‐Shazly, Tsen‐Ni Tsai, Tzu‐Yung Lin, Shou‐Ping Shih, Tony Eight Lin, Zhi‐Hong Wen, Yu‐Chen S. H. Yang, Yi‐Chang Liu   +10 more
wiley   +1 more source

A Vicinal Diol Approach for the Total Synthesis of Molestin E, ent‐Sinulacembranolide A and ent‐Sinumaximol A

Chemistry – A European Journal, Volume 28, Issue 63, November 11, 2022., 2022
The convergent total synthesis of furanocembranoids (FC) molestin E, ent‐sinulacembranolide A and ent‐sinumaximol A was achieved in 20–21 steps in the longest linear sequence (LLS). Building blocks were coupled through a furan metalation sequence and macrocycle formation was effected by Shiina lactonisation. The primary target molestin E was elaborated
Oskar Hoff, Nicolas Kratena, Daniya Aynetdinova, Kirsten E. Christensen, Timothy J. Donohoe   +4 more
wiley   +1 more source

Oxygenating Biocatalysts for Hydroxyl Functionalisation in Drug Discovery and Development

ChemMedChem, Volume 17, Issue 12, June 20, 2022., 2022
C−H bond oxyfunctionalisation is a significant challenge in organic synthetic chemistry. In drug discovery and development, exploiting biocatalytic methods which can introduce hydroxyl groups deftly with high selectivity, under mild conditions, is of paramount interest.
Sacha N. Charlton, Martin A. Hayes
wiley   +1 more source

The chemotype core collection of genus Nicotiana

The Plant Journal, Volume 110, Issue 5, Page 1516-1528, June 2022., 2022
SUMMARY Sustainable production of chemicals and improving these biosources by engineering metabolic pathways to create efficient plant‐based biofactories relies on the knowledge of available chemical/biosynthetic diversity present in the plant. Nicotiana species are well known for their amenability towards transformation and other new plant breeding ...
Margit Drapal, Eugenia M. A. Enfissi, Paul D. Fraser   +2 more
wiley   +1 more source

Phylogeny, Phytomedicines, Phytochemistry, Pharmacological Properties, and Toxicity of Croton gratissimus Burch (Euphorbiaceae)

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2022, Issue 1, 2022., 2022
Croton gratissimus is an important plant in Africa setup and across the globe for its ethnomedicinal uses in managing a wide range of diseases. Its phylogeny, pharmacological properties, ethnomedicinal uses, phytochemistry, and cytotoxicity have been highlighted in various articles and journals.
Kirkland Dingili Magwilu, Joseph Mwanzia Nguta, Isaac Mapenay, Dorine Matara, Srinivas Mutalik   +4 more
wiley   +1 more source

Cembrene Diterpenoids with Ether Linkages from Sarcophyton ehrenbergi: An Anti-Proliferation and Molecular-Docking Assessment

Marine Drugs, 2017
Three new cembrene diterpenoids, sarcoehrenbergilid A–C (1–3), along with four known diterpenoids, sarcophine (4), (+)-7α,8β-dihydroxydeepoxysarcophine (5), sinulolide A (6), and sinulolide B (7), and one steroid, sardisterol (8), were isolated and ...
Mohamed-Elamir F. Hegazy, Abdelsamed I. Elshamy, Tarik A. Mohamed, Ahmed R. Hamed, Mahmoud A. A. Ibrahim, Shinji Ohta, Paul W. Paré   +6 more
doaj   +1 more source

Enzymkatalysierte späte Modifizierungen: Besser spät als nie

Angewandte Chemie, Volume 133, Issue 31, Page 16962-16993, July 26, 2021., 2021
Späte Modifizierungen sind unerlässlich für die Diversifizierung von Verbindungen in der Synthese. Da Enzyme effiziente Werkzeuge für milde, Katalysator‐kontrollierte Funktionalisierungen bieten, sind neue biokatalytische Methoden für eine große Fülle orthogonaler Reaktionen entstanden.
Elvira Romero, Bethan S. Jones, Bethany N. Hogg, Arnau Rué Casamajo, Martin A. Hayes, Sabine L. Flitsch, Nicholas J. Turner, Christian Schnepel   +7 more
wiley   +1 more source

Enzymatic Late‐Stage Modifications: Better Late Than Never

Angewandte Chemie International Edition, Volume 60, Issue 31, Page 16824-16855, July 26, 2021., 2021
Late‐stage modification is an indispensable approach for compound diversification in synthesis. Since enzymes offer particularly powerful means for mild, catalyst‐controlled functionalisations, in recent years several novel biocatalytic methods have emerged enabling a broad array of orthogonal reactions.
Elvira Romero, Bethan S. Jones, Bethany N. Hogg, Arnau Rué Casamajo, Martin A. Hayes, Sabine L. Flitsch, Nicholas J. Turner, Christian Schnepel   +7 more
wiley   +1 more source