Results 51 to 60 of about 1,301 (143)

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Selection and validation of reference genes by RT-qPCR for murine cementoblasts in mechanical loading experiments simulating orthodontic forces in vitro

Scientific Reports, 2020
Different structures and cell types of the periodontium respond to orthodontic tooth movement (OTM) individually. Cementoblasts (OC/CM) located in the immediate vicinity of the fibroblasts on the cement have found way to the centre of actual research ...
Christian Niederau, Rogerio B. Craveiro, Irma Azraq, Julia Brockhaus, Asisa Bastian, Christian Kirschneck, Michael Wolf   +6 more
doaj   +1 more source

Autophagy mediates cementoblast mineralization under compression through periostin/β‐catenin axis [PDF]

, 2023
Yuhui Yang, Hao Liu, Ruoxi Wang, Yi Zhao, Yunfei Zheng, Yiping Huang, Weiran Li   +6 more
openalex   +1 more source

Hyaluronic acid: A novel approach in regenerative/reconstructive periodontal therapy?

Periodontology 2000, EarlyView.
Abstract Background Although hyaluronic acid (HA) has long been used for many medical applications, only in recent years has it gained greater popularity in the field of periodontics because of its biological effects during wound healing. Even today, most clinicians are not aware that more than one type of HA exists and that the extent of its ...
Andrea Pilloni, Yoshinori Shirakata, Lorenzo Marini, Darko Božić, Richard J. Miron, Roberto Rotundo, Andreas Stavropoulos, Anton Sculean   +7 more
wiley   +1 more source

Astaxanthin Reverses Oxidative Stress‐Induced Dysfunction in Human Periodontal Ligament Stem Cells by Activating the Nrf2/ARE Pathway

Stem Cells International, Volume 2026, Issue 1, 2026.
Background Oxidative stress plays a crucial role in the pathogenesis of periodontitis and compromises the regenerative potential of human periodontal ligament stem cells (hPDLSCs). Astaxanthin (ASX), a potent natural antioxidant with both lipophilic and hydrophilic properties, has been shown to scavenge reactive oxygen species (ROS).
Jingwen Chi, Xiaofei Yu, Hui Zhang, Mengyu Jiao, Peiyan Wang, Kexin Wang, Tianlu Wang, Jing Deng, Zhiwen Luo   +8 more
wiley   +1 more source

Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development

Advanced Biology, Volume 9, Issue 12, December 2025.
Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang   +10 more
wiley   +1 more source

Leucine rich amelogenin peptide prevents ovariectomy-induced bone loss in mice.

PLoS ONE, 2021
Amelogenins, major extra cellular matrix proteins of developing tooth enamel, are predominantly expressed by ameloblasts and play significant roles in the formation of enamel.
Naoto Haruyama, Takayoshi Yamaza, Shigeki Suzuki, Bradford Hall, Andrew Cho, Carolyn W Gibson, Ashok B Kulkarni   +6 more
doaj   +1 more source

Effects of nicotine on cell growth, migration, and production of inflammatory cytokines and reactive oxygen species by cementoblasts

Journal of Dental Sciences, 2015
Background/purpose: Cigarette smoking is an important risk factor in the pathogenesis of periodontal disease. However, little is known about the effect of nicotine, the major component of cigarette smoke, on cementoblasts.
Chun-San Chen, Shiuan-Shinn Lee, Hui-Chieh Yu, Fu-Mei Huang, Yu-Chao Chang   +4 more
doaj   +1 more source

Pyrophosphate Regulates Multilineage Differentiation in Stem Cells From Human Exfoliated Deciduous Teeth

Clinical and Experimental Dental Research, Volume 11, Issue 6, December 2025.
ABSTRACT Background To explore the cellular behavior of stem cells derived from human exfoliated deciduous teeth (SHED) in response to inorganic pyrophosphate (PPi). Materials and Methods SHED cells were isolated from the dental pulp tissues of human primary exfoliated teeth.
Ravipha Suwittayarak, Nunthawan Nowwarote, Chatvadee Kornsuthisopon, Waleerat Sukarawan, Brian L. Foster, Hiroshi Egusa, Thanaphum Osathanon   +6 more
wiley   +1 more source

Y‐Box‐Binding Protein 1 Facilitates the Proliferation and Osteogenic Differentiation of Periodontal Ligament Stem Cells Through the Transcriptional Activation of FGF2‐Mediated Akt/GSK3β/β‐Catenin Signaling

The Kaohsiung Journal of Medical Sciences, Volume 41, Issue 12, December 2025.
ABSTRACT Periodontal ligament stem cells (PDLSCs) are derived from periodontal tissue and can differentiate into osteoblasts, which are ideal materials for alveolar bone repair and periodontal tissue regeneration. In this study, we aimed to explore the effects of Y‐box binding protein 1 (YB‐1) on the osteogenic differentiation and proliferation of ...
Yun‐Hao Xi, Chang‐Shun Li, Pin‐Lin Wu, Xiao‐Yang Zhou, Qian‐Wen Li, Cheng‐Hui Shen   +5 more
wiley   +1 more source