Periodontal regeneration: Lessons from the periodontal ligament-cementum junction in diverse animal models [PDF]
Frontiers in Dental Medicine, 2023 The attachment of the roots of mammalian teeth of limited eruption to the jawbone is reliant in part on the mineralization of collagen fibrils of the periodontal ligament (PDL) at their entry into bone and cementum as Sharpey's fibers.
Eli D. Sone +3 more
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Overlapping functions of bone sialoprotein and pyrophosphate regulators in directing cementogenesis [PDF]
Bone, 2017 Although acellular cementum is essential for tooth attachment, factors directing its development and regeneration remain poorly understood. Inorganic pyrophosphate (PPi), a mineralization inhibitor, is a key regulator of cementum formation: tissue-nonspecific alkaline phosphatase (Alpl/TNAP) null mice (increased PPi) feature deficient cementum, while ...
Min Ao +10 more
semanticscholar +5 more sources
The long non‐coding
Orthodontics & craniofacial research, 2023 OBJECTIVE Stimulation of cementogenesis is essential to cementum regeneration and root restoration. Long non-coding RNAs (lncRNAs) participate in the regulatory networks of periodontal regeneration processes.
Yingying Zhang, Yiping Huang
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Molecules and Cells, 2017 The periodontal ligament (PDL) is the connective tissue between tooth root and alveolar bone containing mesenchymal stem cells (MSC). It has been suggested that human periodontal ligament stem cells (hPDLSCs) differentiate into osteo/cementoblast and ...
Sun‐Yi Hyun +3 more
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Combination of Periodontal Ligament Stem Cells and Metformin via Organic Cation Transporters for Periodontal Regeneration in Rats [PDF]
BiomoleculesPeriodontal regeneration remains challenging due to individual variability, especially in treatments involving bioactive factors such as metformin.
Qingchen Qiao +9 more
doaj +2 more sources
Bone Morphogenetic Protein 7 Promotes the Differentiation of Periodontal Ligament Fibroblasts into F-Spondin-Expressing Cementoblast-like Cells During Root Canal Treatment—An In Vivo Rat Pulpectomy Model and In Vitro Human Fibroblast Study [PDF]
Dentistry JournalBackground/Objectives: The optimal healing process following root canal treatment involves biological apical sealing through new cementum formation.
Hiroki Iwasawa +5 more
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Evaluating the role of a novel homeodomain protein in periodontal regenerative therapy: An in-vitro study [PDF]
Journal of Oral Biology and Craniofacial ResearchIntroduction: The goal of periodontal treatment is to halt disease progression and restore the structure and function of damaged periodontal tissues.
Bhavya Shetty +5 more
doaj +2 more sources
Nanosilicates facilitate periodontal regeneration potential by activating the PI3K-AKT signaling pathway in periodontal ligament cells [PDF]
Journal of NanobiotechnologyThe recent development of nanobiomaterials has shed some light on the field of periodontal tissue regeneration. Laponite (LAP), an artificially synthesized two-dimensional (2D) disk-shaped nanosilicate, has garnered substantial attention in regenerative ...
Ziqin Chen +9 more
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Coronal Cementum and Reduced Enamel Epithelium on Occlusal Surface of Impacted Wisdom Tooth in a Human [PDF]
Dentistry JournalBackground: There is only limited research on the coronal cementum of a tooth, and the mechanisms of its forming process are not well-defined. This report presents a coronal cementum on the occlusal surfaces of enamel in an impacted wisdom tooth in a ...
Naohiro Horie +8 more
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CXXC5 Mitigates P. gingivalis-inhibited Cementogenesis by influencing Mitochondrial Biogenesis [PDF]
Cell Communication and Signaling, 2023 Abstract Background Cementoblasts are tooth-root surface-lining cells responsible for cementum formation (cementogenesis) and sensitive to Porphyromonas gingivalis stimulation. We have previously proved transcription factor CXXC-type zinc finger protein 5 (CXXC5) participates in cementogenesis.
Li Ma +7 more
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