Results 41 to 50 of about 1,087 (181)

Correction: Precision management of cenobamate in drug-resistant epilepsy: integrating pharmacogenetics, therapeutic drug monitoring, and real-world clinical strategies [PDF]

Frontiers in Pharmacology
Giuseppe d'Orsi, Maria Teresa Di Claudio, Alessia Cafaro, Sebastiano Barco, Marta Robustella, Nicolò Locatelli, Antonella Liantonio, Paola Imbrici, Grazia Ciavarella, Antonio Rinaldi, Giuseppe Fania, Umberto Costantino, Massimo Carella, Giuliana Cangemi, Giuseppe Miscio   +14 more
doaj   +2 more sources

Cenobamate, a Sodium Channel Inhibitor and Positive Allosteric Modulator of GABA_A Ion Channels, for Partial Onset Seizures in Adults: A Comprehensive Review and Clinical Implications

Neurology International, 2021
Medical management of epilepsy seeks to eliminate or to reduce the frequency of seizures, help patients maintain a normal lifestyle, and maintain psychosocial and occupational activities, while avoiding the negative side effects of long-term treatment ...
Dustin R. Latimer, Amber N. Edinoff, Rachel D. Ruff, Kelsey C. Rooney, Kayla M. Penny, Shaan B. Patel, Suresh Sabbenahalli, Adam M. Kaye, Elyse M. Cornett, Omar Viswanath, Ivan Urits, Alan D. Kaye   +11 more
doaj   +1 more source

Use of cenobamate for the treatment of focal epilepsy: an Italian expert opinion paper

, 2023
Cenobamate is a new antiseizure medication (ASM) recently introduced in the USA for the treatment of adults with focal-onset seizures. In March 2021, the European Commission authorized its use for the adjunctive treatment of focal-onset seizures with or ...
Flavio Villani (5337305), Carlo Di Bonaventura (8639766), Giancarlo Di Gennaro (9082931), Carlo Andrea Galimberti (10829484), Oriano Mecarelli (6066689), Nicola Specchio (10683382), Nicola Pietrafusa (10829496), Federico Vigevano (4252132), Emilio Perucca (9676382), Vittoria Cianci (3132885), Renzo Guerrini (213811), Angela La Neve (9560534)   +11 more
core   +1 more source

Long‐term individual retention with cenobamate in adults with focal seizures: Pooled data from the clinical development program

, 2022
OBJECTIVE: We determined retention on open‐label cenobamate therapy in the clinical development program to assess the long‐term efficacy and tolerability of adjunctive cenobamate in individuals with uncontrolled focal seizures.
Manuel Toledo, Victor Biton, William E. Rosenfeld, Steinhoff, Bernhard, Biton, Victor, Jonathan J. Halford, Halford, Jonathan J., Sander, Josemir W., Rosenfeld, William E., Josemir W. Sander, Bernhard J. Steinhoff, Toledo, Manuel, Steinhoff, Bernhard J.   +12 more
core   +1 more source

Onset of efficacy and adverse events during Cenobamate titration period [PDF]

, 2022
Cenobamate; Drug-resistant epilepsy; SeizuresCenobamato; Epilepsia resistente a los medicamentos; ConvulsionesCenobamat; Epilèpsia resistent a medicaments; ConvulsionsObjectives Cenobamate is an antiseizure medication (ASM) approved in Europe as ...
Santamarina, E., Serratosa, José M., Brandt, Christian, Ben-Menachem, Elinor,, García Morales, Irene, Ben-Menachem, Elinor, Santamarina, Estevo, Rosenfeld, William, Steinhoff, Bernhard, Brandt, C., Santamarina Pérez, Estevo, García-Morales, Irene, Rosenfeld, W. E., Ben‐Menachem, Elinor, Morales, I. G., Serratosa, J. M., Rosenfeld, William E., Steinhoff, Bernhard J., Steinhoff, B. J., William E. Rosenfeld, Elinor Ben‐Menachem, Irene García Morales, José M. Serratosa, Bernhard J. Steinhoff, Christian Brandt, Estevo Santamarina   +25 more
core   +1 more source

Obstructive Sleep Apnea in Children With Lennox‐Gastaut Syndrome: A Case Series

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Background Lennox–Gastaut syndrome (LGS) is a highly refractory epilepsy syndrome associated with poor sleep. Abnormal sleep can lower seizure threshold, yet a treatable cause of disordered sleep, obstructive sleep apnea (OSA), is understudied in children with LGS.
Gita Gupta, Louise M. O'Brien, Fauziya Hassan, Stephanie M. D. Rau, Arushi Gupta, Renée A Shellhaas   +5 more
wiley   +1 more source

Unintended Pregnancies and Breastfeeding Studies during Central Nervous System Drug Development: How Are they Handled, Is There Room for Improvement?

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant and breastfeeding individuals are routinely excluded from clinical drug development, creating persistent evidence gaps in pharmacology, safety, and dosing. Despite mandatory contraception and pregnancy testing, unintended pregnancies occur, particularly during the development of central nervous system (CNS) medicines used by women of ...
Sam Schoenmakers, Charlotte Bakker, Alexandra Ganev, Florence Butlen‐Ducuing, Corinne S. de Vries   +4 more
wiley   +1 more source

Cenobamate: A comprehensive review

Seizure: European Journal of Epilepsy
This article provides a review of cenobamate's (CNB's) pharmacology, mechanisms of action, efficacy, safety, and seizure/epilepsy types treated. CNB is an antiseizure medication approved in the U.S. in 2019 for treatment of adults with focal (partial-onset) seizures.
David G Vossler, Raman Sankar
openaire   +2 more sources

The burden of the postictal state in epilepsy: A prospective, single‐center observational cohort study

Epileptic Disorders, EarlyView.
Abstract Objective The postictal state is a major yet underrecognized component of the epilepsy burden. We aimed to develop a structured patient‐reported instrument to quantify postictal recovery, characterize its multidimensional burden, and identify demographic, clinical, psychiatric, and treatment‐related factors associated with postictal severity ...
Ionuț‐Flavius Bratu, Agnès Trébuchon, Fabrice Bartolomei   +2 more
wiley   +1 more source

A retrospective non-interventional study evaluating the pharmacokinetic interactions between cenobamate and clobazam

, 2023
Elakkary S, Hagemann A, Klimpel D, Bien C, Brandt C. A retrospective non-interventional study evaluating the pharmacokinetic interactions between cenobamate and clobazam. Epilepsia.
Elakkary, Sally, Hagemann, Anne, Brandt, Christian, Bien, Christian, Klimpel, Dennis, Anne Hagemann, Christian G. Bien, Dennis Klimpel, Sally Elakkary, Christian Brandt   +9 more
core   +1 more source