Results 31 to 40 of about 796 (164)

Anti‐Seizure Medications Alter Functional and Effective Connectivity as Measured With Intracranial Electroencephalography

Brain and Behavior, Volume 16, Issue 6, June 2026.
ASMs affected the effective connectivity within the seizure network more than in the healthy network. Alterations in functional connectivity were found within the healthy network. ABSTRACT Background Anti‐seizure medications (ASMs) control seizures through distinct neuronal mechanisms. While suppressing seizures, putative spill‐over effects can lead to
Serdar Akkol, Helen E. Brinyark, Rebekah Chatfield, Aparna Vaddiparti, Rachel June Smith, Benjamin C. Cox   +5 more
wiley   +1 more source

Use of cenobamate for the treatment of focal epilepsy: an Italian expert opinion paper

, 2023
Cenobamate is a new antiseizure medication (ASM) recently introduced in the USA for the treatment of adults with focal-onset seizures. In March 2021, the European Commission authorized its use for the adjunctive treatment of focal-onset seizures with or ...
Flavio Villani (5337305), Carlo Di Bonaventura (8639766), Giancarlo Di Gennaro (9082931), Carlo Andrea Galimberti (10829484), Oriano Mecarelli (6066689), Nicola Specchio (10683382), Nicola Pietrafusa (10829496), Federico Vigevano (4252132), Emilio Perucca (9676382), Vittoria Cianci (3132885), Renzo Guerrini (213811), Angela La Neve (9560534)   +11 more
core   +1 more source

A french real-world experience with cenobamate in patients with drug-resistant focal epilepsy: A retrospective observational study. [PDF]

Epilepsy Behav Rep
Epilepsy is a common and disabling neurological disorder. To significantly improve the quality of life of patients, the primary goal is to achieve seizure freedom.
Plaquevent A, Goff FL, Chastan N.
europepmc   +2 more sources

Severe Cutaneous Adverse Reactions Associated With Newer‐Generation Antiseizure Medications: A Real‐World Pharmacovigilance Study Based on FAERS and JADER

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
A cross‐database analysis of FAERS and JADER confirmed lamotrigine and zonisamide as the dominant SJS/TEN/DRESS risk drivers across both systems. After polytherapy adjustment, eslicarbazepine (DRESS, ROR 10.41) and levetiracetam emerged as reproducible novel signals warranting clinical attention. SJS/TEN onset concentrated within 4 weeks, whereas DRESS
Longfei You, Dong Zhang, Zhihua Cheng, Yinbao Qi, Ruobing Qian   +4 more
wiley   +1 more source

Critical Appraisal of Cenobamate as Adjunctive Treatment of Focal Seizures in Adults

, 2021
Gaetano Zaccara,1 Simona Lattanzi,2 Antonio Leo,3 Emilio Russo3 1Regional Health Agency of Tuscany, Firenze, Italy; 2Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy; 3Science of Health ...
Lattanzi S, Russo E, Russo E., Zaccara G, Leo A., Lattanzi S., Zaccara G., Leo A   +7 more
core   +1 more source

Drug-Induced Subacute Cutaneous Lupus Erythematous From Cenobamate: Case Presentation and Review of the Literature [PDF]

A 68-year-old woman with a history of seizures on cenobamate presented with an itchy rash all over her body. The rash started about one month prior to her presentation to the dermatology clinic.
Webster, Timothy, Joffe, Daniel, Nikbakht, Neda, Bhatti, Safiyyah, Lee, Jason   +4 more
core   +3 more sources

Patterns of seizure frequency reduction in clinical trial participants with lower baseline seizure frequency

Epilepsia, Volume 67, Issue 6, Page 2808-2819, June 2026.
Abstract Objective Inclusion and exclusion criteria of clinical trials for seizures aim to select representative participants with a high enough seizure frequency to evaluate the efficacy of treatment in a relatively short double‐blind period. To inform the selection of seizure frequency‐based inclusion criteria, we evaluated the association between ...
Wesley T. Kerr, Advith S. Reddy, Neo Kok, Katherine N. McFarlane, Lavanya Biju, Jacqueline A. French   +5 more
wiley   +1 more source

Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia

Epilepsia, Volume 67, Issue 6, Page 2992-3008, June 2026.
Abstract Objective Focal cortical dysplasia (FCD) causes drug‐resistant epilepsy requiring presurgical evaluation. Invasive electroencephalographic (EEG) studies demonstrate that sleep modulates epileptic activity, including interictal epileptiform discharges (IEDs), fast oscillations (FOs) in the beta (14–40 Hz) and gamma (40–80 Hz) frequency bands ...
Marcel Heers, Jawata Afnan, Christoph Braun, Christophe Grova, Dirk‐Matthias Altenmüller, Bernhard J. Steinhoff, Matthias Dümpelmann, Theo Demerath, Horst Urbach, Silke Ethofer, Markus Siegel, Andreas Schulze‐Bonhage, Holger Lerche, Yiwen Li Hegner   +13 more
wiley   +1 more source

Cenobamate add-on therapy for drug-resistant focal epilepsy

Background: Although most people with epilepsy achieve complete seizure cessation, approximately one-third of those with the condition continue experiencing seizures despite the use of antiseizure medications (ASMs) given as monotherapy or polytherapy ...
Brigo, Francesco, Lattanzi, Simona
core   +1 more source

Women with epilepsy: Evidence‐based counseling across the lifespan

Epilepsia, Volume 67, Issue 6, Page 2689-2706, June 2026.
Abstract Women with epilepsy (WWE) encounter distinct and evolving challenges across the lifespan that require clinical management extending beyond seizure control alone. Although awareness of sex‐specific aspects of epilepsy has increased, important gaps remain in their integration into routine care.
Barbara Tettenborn, Georgia Ramantani, Dominique Flügel, Verena Gaus, Susanne Schubert‐Bast, Elisabeth Sellitto, Jennifer Bausch, Bettina Schmitz   +7 more
wiley   +1 more source