Results 11 to 20 of about 796 (164)

Increase of Brivaracetam serum concentration with introduction of Cenobamate [PDF]

Frontiers in Pharmacology
IntroductionCenobamate is a new antiseizure medication approved for polytherapy of focal epilepsy with complex hepatic metabolism and effects on liver enzymes. So far, data are limited with regard to possible interactions with other antiseizure medications.
Lena Bender, Martin Hirsch, Andreas Schulze-Bonhage   +2 more
openaire   +4 more sources

Adjunctive Cenobamate for Focal-Onset Seizures in Adults: A Systematic Review and Meta-Analysis. [PDF]

, 2020
BACKGROUND Cenobamate is a novel tetrazole-derived carbamate compound with a dual mechanism of action. This drug can enhance the inactivated state of voltage-gated sodium channels, preferentially inhibiting the persistent component of the sodium ...
Silvestrini, Mauro, Trinka, Eugen, Striano, Pasquale, Del Giovane, Cinzia, Zaccara, Gaetano, Brigo, Francesco, Lattanzi, Simona   +6 more
core   +3 more sources

Onset of efficacy and adverse events during Cenobamate titration period [PDF]

, 2022
Cenobamate; Drug-resistant epilepsy; SeizuresCenobamato; Epilepsia resistente a los medicamentos; ConvulsionesCenobamat; Epilèpsia resistent a medicaments; ConvulsionsObjectives Cenobamate is an antiseizure medication (ASM) approved in Europe as ...
Santamarina, E., Serratosa, José M., Brandt, Christian, Ben-Menachem, Elinor,, García Morales, Irene, Ben-Menachem, Elinor, Santamarina, Estevo, Rosenfeld, William, Steinhoff, Bernhard, Brandt, C., Santamarina Pérez, Estevo, García-Morales, Irene, Rosenfeld, W. E., Ben‐Menachem, Elinor, Morales, I. G., Serratosa, J. M., Rosenfeld, William E., Steinhoff, Bernhard J., Steinhoff, B. J.   +18 more
core   +1 more source

Adjunctive cenobamate for the treatment of focal onset seizures in adults with epilepsy: a critical review

, 2022
Uncontrolled epilepsy has persisted despite development of numerous antiseizure medications (ASMs) over the past 25 years, and more effective treatments are needed.
James W. Wheless (6034235)
core   +1 more source

Anticonvulsant effects of cenobamate in chemically and electrically induced seizure models in rodents

, 2023
Background: Cenobamate is an antiseizure medication used to treat partial-onset (focal) seizures. It is a molecule with one chiral center and a unique dual mechanism of action: enhancement of fast and slow inactivation of sodium channels with ...
Kelli J. Glenn, Susan M. Melnick, Yujin Shin   +2 more
core   +1 more source

Early Introduction of Cenobamate in Uncontrolled Focal Epilepsy: Insights from a Structured Controversy. [PDF]

Neurol Ther
Introduction: Drug-resistant focal epilepsy, as defined by the International League Against Epilepsy (ILAE), is characterized by the failure to achieve seizure control despite the use of at least two appropriately chosen and adequately dosed antiseizure ...
Labate A, Liguori C, Tartara E, Tumminelli G, Nilo A, Piccioli M, Dainese F, Del Gaudio L, Di Bonaventura C.   +8 more
europepmc   +2 more sources

A retrospective non-interventional study evaluating the pharmacokinetic interactions between cenobamate and clobazam

, 2023
Elakkary S, Hagemann A, Klimpel D, Bien C, Brandt C. A retrospective non-interventional study evaluating the pharmacokinetic interactions between cenobamate and clobazam. Epilepsia.
Elakkary, Sally, Hagemann, Anne, Brandt, Christian, Bien, Christian, Klimpel, Dennis, Anne Hagemann, Christian G. Bien, Dennis Klimpel, Sally Elakkary, Christian Brandt   +9 more
core   +1 more source

The ups and downs of alkyl-carbamates in epilepsy therapy: How does cenobamate differ? [PDF]

, 2021
Since 1955, several alkyl‐carbamates have been developed for the treatment of anxiety and epilepsy, including meprobamate, flupirtine, felbamate, retigabine, carisbamate, and cenobamate.
H. Steve White, Löscher, Wolfgang, White, H. Steve, Sills, Graeme J., Wolfgang Löscher, Graeme J. Sills   +5 more
core   +1 more source

Cost-effectiveness of cenobamate for focal seizures in people with drug-resistant epilepsy [PDF]

, 2023
OBJECTIVES: To estimate the cost-effectiveness of add-on cenobamate in the UK when used to treat drug-resistant focal seizures in adults who are not adequately controlled with at least two prior antiseizure medication, including at least one used ...
Laskier, Vicki, Agyei-Kyeremateng, Kenneth K, Mulheron, Stuart, Thomas, Rhys H, James, Samuel, Eddy, Alex E, Patel, Dilip, Sander, Josemir W   +7 more
core   +2 more sources

Pharmacology of Cenobamate: Mechanism of Action, Pharmacokinetics, Drug–Drug Interactions and Tolerability

, 2021
Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended starting dose is 12.5 mg/day, titrated gradually to the target daily dose of 200 mg, which may be ...
Roberti R., Russo E., Iannone L. F., Lattanzi S., Zaccara G., De Caro C.   +5 more
core   +1 more source