Results 11 to 20 of about 1,087 (181)

Advances in Sodium Channel Modulation in Epilepsy Therapy: Focus on Eslicarbazepine, Lacosamide and Cenobamate [PDF]

Biomedicines
Background/Objectives: Voltage-gated sodium channels (VGSCs) are among the most important molecular targets in epilepsy therapy. Unlike classical antiseizure medications (ASMs), newer sodium channel modulators selectively affect slow inactivation or ...
Monika Rudkowska, Jarosław Mołdoch, Olga Wronikowska-Denysiuk, Monika Agacka-Mołdoch, Anna Pradiuch, Karolina Wojtunik-Kulesza   +5 more
doaj   +3 more sources

Cenobamate in super-refractory status epilepticus: current evidence from a patient-level synthesis [PDF]

Frontiers in Neurology
BackgroundSuper-refractory status epilepticus (SRSE) represents a challenging neurological emergency, with limited therapeutic options after conventional intravenous antiseizure medications (ASMs) and continuous anesthetic therapy have failed. Cenobamate
Giovanni Falcicchio, Teresa Francavilla
doaj   +2 more sources

DECREASE study: A European pool‐analysis of patients with significant reductions in concomitant antiseizure medications in cenobamate Early Access Programs [PDF]

Epilepsia Open
Objective To evaluate the effectiveness and tolerability of cenobamate in patients with a significant reduction in concomitant antiseizure medication (ASM) in European cenobamate Early Access Programs (EAPs).
Vicente Villanueva, Simona Lattanzi, Javier Peña‐Ceballos, Rhys H. Thomas, Juan Rodríguez‐Uranga, Zsófia Jordán, Bernhard J. Steinhoff, Randi vonWrede, Norman Delanty, Patrick B. Moloney, Roberta Roberti, Giovanni Boero, Laura Canafoglia, Nicola Specchio, Antonio Gambardella, Edoardo Ferlazzo, Francesca Felicia Operto, Elena Tartara, Hester Garratt, Dániel Fabó, Asier Gómez‐Ibáñez, Gustavo Torres‐Gaona, Yulia Novitskaya, Rainer Surges, Kevin Hampel, Andreas Schulze‐Bonhage   +25 more
doaj   +2 more sources

Cenobamate modulates EEG cortical activity and connectivity in individuals with drug-resistant epilepsy: a pharmaco-EEG study [PDF]

Frontiers in Neurology
ObjectiveQuantitative electroencephalography (qEEG) metrics are demonstrated to correlate with and predict clinical response in individuals with epilepsy.
G. Assenza, G. Assenza, B. Sancetta, B. Sancetta, L. Ricci, L. Ricci, C. Vico, C. Vico, F. Narducci, F. Narducci, M. Boscarino, M. Boscarino, J. Lanzone, P. Menna, C. Liguori, F. Izzi, N. B. Mercuri, V. Di Lazzaro, V. Di Lazzaro, M. Tombini, M. Tombini   +20 more
doaj   +2 more sources

Cenobamate use in super‐refractory status epilepticus: A report of three cases [PDF]

Epileptic Disorders, Volume 28, Issue 5, Page 1661-1668, October 2026.
Abstract Objectives Super‐refractory status epilepticus (SRSE) is a neurological emergency with high morbidity and mortality. Cenobamate, a novel antiseizure medication, may be helpful in managing SRSE, but evidence is limited. Methods This retrospective case series reports the use of cenobamate as add‐on therapy in the management of three cases of ...
Marina Romozzi, Juan Luis Alcala‐Zermeno, Antonio Funcis, Federico Tosto, Marta Piccioli, Luigi Francesco Iannone, Riccardo Maviglia, Masahito Katsuki, Yasuhiko Matsumori, Paolo Calabresi, Raffaele Iorio, Catello Vollono   +11 more
wiley   +2 more sources

Cost-effectiveness of cenobamate as a therapeutic alternative for the treatment of focal epilepsy in adults with inadequate seizure control

Global & Regional Health Technology Assessment
Introduction: This study assesses the cost-effectiveness of cenobamate relative to brivaracetam, lacosamide, eslicarbazepine acetate, and perampanel in the management of focal onset seizures (FOS). The objective is to determine whether cenobamate offers
Martina Paoletti, Angela Ragonese, Luca Budassi, Andrea Marcellusi   +3 more
doaj   +2 more sources

Effectiveness and Safety of Adjunctive Cenobamate in People with Focal-Onset Epilepsy: Evidence from the First Interim Analysis of the BLESS Study [PDF]

Neurology and Therapy
Introduction Despite new anti-seizure medications (ASMs) being introduced into clinical practice, about one-third of people with epilepsy do not reach seizure control.
Simona Lattanzi, Federica Ranzato, Carlo Di Bonaventura, Paolo Bonanni, Antonio Gambardella, Elena Tartara, Giovanni Assenza, Michela Procaccini, Nathalie Falsetto, Valentina Villano, Gabriele Camattari, Alessandra Ori, Giancarlo Di Gennaro, on behalf of the BLESS Study Group   +13 more
doaj   +2 more sources

Therapeutic strategies during cenobamate treatment initiation: Delphi panel recommendations [PDF]

Therapeutic Advances in Neurological Disorders
The goal of epilepsy treatment is seizure freedom, typically with antiseizure medication (ASM). If patients fail to attain seizure control despite two trials of appropriately chosen ASMs at adequate doses, they are classified as having drug-resistant ...
Bernhard J. Steinhoff, Elinor Ben-Menachem, Pavel Klein, Jukka Peltola, Bettina Schmitz, Rhys H. Thomas, Vicente Villanueva   +6 more
doaj   +5 more sources

Early Introduction of Cenobamate in Uncontrolled Focal Epilepsy: Insights from a Structured Controversy [PDF]

Neurology and Therapy
Introduction Drug-resistant focal epilepsy, as defined by the International League Against Epilepsy (ILAE), is characterized by the failure to achieve seizure control despite the use of at least two appropriately chosen and adequately dosed antiseizure ...
Angelo Labate, Claudio Liguori, Elena Tartara, Gemma Tumminelli, Annacarmen Nilo, Marta Piccioli, Filippo Dainese, Luigi Del Gaudio, Carlo Di Bonaventura   +8 more
doaj   +2 more sources

Narrative Review: Efficacy, Safety, and Tolerability of Newer Third-Generation Antiseizure Medications for Focal Epilepsy: A New Benchmark in Treatment Outcomes? [PDF]

Neurology and Therapy
Introduction Focal seizures are the most common form of epilepsy. This narrative review analyzes the efficacy, safety, and tolerability of five newer third-generation antiseizure medications (ASMs) approved for treatment of focal seizures: lacosamide ...
William E. Rosenfeld, Pavel Klein, Louis Ferrari, Vicente Villanueva   +3 more
doaj   +2 more sources