The Cardiac Sodium Channel Safety Profile of Cenobamate at Therapeutic Concentrations: In Vitro Analyses [PDF]
Clinical and Translational ScienceThe US Food and Drug Administration (FDA) issued a Drug Safety Communication for the antiseizure drug lamotrigine (Lamictal), warning of the risk of QRS prolongation and cardiac arrhythmias.
William J. Crumb Jr +2 more
doaj +2 more sources
BiomoleculesCenobamate is a novel third-generation antiepileptic drug used for the treatment of focal onset seizures and particularly for multi-drug-resistant epilepsy; it acts on multiple targets: GABAA receptors (EC50 42–194 µM) and persistent neuronal Na ...
Andreea Larisa Mateias +4 more
doaj +2 more sources
Prospective study of cenobamate on cognition, affectivity, and quality of life in focal epilepsy
Epilepsia OpenObjective Cenobamate is a recently approved antiseizure medication that proved to be safe and effective in randomized controlled trials. However, little is known about its impact on some areas frequently affected by epilepsy. For this reason, we explored
Judit Catalán‐Aguilar +7 more
doaj +2 more sources
Exploring the Role of Early Add-On Cenobamate in Uncontrolled Focal Epilepsy: A Critical Appraisal of the Evidence [PDF]
Neurology and TherapyIntroduction Cenobamate is a third-generation antiseizure medication (ASM) for the treatment of uncontrolled focal seizures. As evidence accumulated across randomized clinical trials and real-world studies, clinically relevant questions have emerged ...
Simona Lattanzi +4 more
doaj +2 more sources
Sustained seizure reduction, treatment simplification, and high retention with cenobamate: A 12‐month real‐world study in refractory and ultra‐refractory focal epilepsy [PDF]
Epilepsia OpenObjective To assess the 12‐month clinical impact of cenobamate (CNB) in adults with drug‐resistant focal epilepsy in clinical practice, exploring whether outcomes differed according to prior antiseizure medication (ASM) exposure.
Francesca Cutropia +13 more
doaj +2 more sources
Real‐world use of Cenobamate in pediatric drug‐resistant epilepsy: A European multicenter retrospective study [PDF]
Epilepsia OpenPediatric drug‐resistant epilepsy (DRE) remains a significant clinical challenge, with few effective pharmacological options. This European multicenter retrospective study assessed the real‐world efficacy, tolerability, and retention of off‐label ...
Konstantin L. Makridis +14 more
doaj +2 more sources
Hypersensitivity reaction risk when restarting cenobamate after discontinuation: Insights from a prolonged hospitalized cohort [PDF]
Epilepsia OpenObjective To evaluate the risk of hypersensitivity reactions, including dermatological rashes, when cenobamate (CNB) is restarted at maintenance doses after temporary discontinuation.
Marina Feldman +4 more
doaj +2 more sources
Cost-effectiveness of cenobamate for focal seizures in people with drug-resistant epilepsy [PDF]
, 2023 OBJECTIVES: To estimate the cost-effectiveness of add-on cenobamate in the UK when used to treat drug-resistant focal seizures in adults who are not adequately controlled with at least two prior antiseizure medication, including at least one used ...
Laskier, Vicki +7 more
core +7 more sources
Long-Term Impact of Cenobamate on Cognition, Adaptive Behavior, and Quality of Life in Patients with Tuberous Sclerosis Complex [PDF]
Neurology and TherapyIntroduction Cenobamate is a recent therapeutic option for epilepsy, but few studies have investigated its impact on cognitive and emotional/behavioral functioning. The aim of our study was to assess cognitive function, adaptive behavior, quality of life,
Francesca Felicia Operto +9 more
doaj +2 more sources
Cenobamate’s effect on mood and seizure frequency [PDF]
Epilepsy & BehaviorReal-world experience with efficacy and tolerability of newly approved antiseizure medications (ASM) often diverges from findings in their controlled clinical trials. Cenobamate (CNB), demonstrated a high responder rate and seizure freedom in placebo-controlled trials.
Mert Karatas +8 more
openaire +4 more sources