Results 31 to 40 of about 10,375 (215)

Old age rational suicide [PDF]

, 2017
In the societal debate surrounding voluntary euthanasia or physician-assisted suicide, there is a concern that older people will be left exposed to any legislation, subject to either faint suggestion or outright coercion from familial or professional ...
Richards, Naomi
core   +1 more source

Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing [PDF]

, 2012
Background: MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression and play a critical role in development, homeostasis, and disease.
Atzmon, G. (Gil), Barzilai, A. (Ari), Calder, B. (Brent), Campisi, J. (Judith), Dong, F. (Fei), Gombar, S. (Saurabh), Hoeijmakers, J.H.J. (Jan), Jung, H.J. (Hwa), Pothof, J. (Joris), Suh, Y. (Yousin), Tian, X.-L. (Xiao-Li), Vijg, J. (Jan)   +11 more
core   +1 more source

Maintaining oral health for a hundred years and more? - An analysis of microbial and salivary factors in a cohort of centenarians

Journal of Oral Microbiology, 2022
Aim To investigate associations between oral health-related conditions and the oral microbiome in a representative study sample of centenarians.Materials and methods Clinical and microbial parameters from 54 centenarians were assessed in the Heidelberg ...
Caroline Sekundo, Eva Langowski, Diana Wolff, Sébastien Boutin, Cornelia Frese   +4 more
doaj   +1 more source

Evidence for less marked potential signs of T-cell immunosenescence in centenarian offspring than in the general age-matched population [PDF]

, 2014
People may reach the upper limits of the human life span at least partly because they have maintained more appropriate immune function, avoiding changes to immunity termed "immunosenescence." Exceptionally long-lived people may be enriched for genes that
Buffa, S., Bulati, M., Caruso, C., COLONNA ROMANO, G., Goldeck, D., Martorana, A., Pawelec, G., Pellican\uf2, M.   +7 more
core   +1 more source

Ideal Cardiovascular Health in the Oldest-Old and Centenarians and Its Association With Disability and Health-Related Quality of Life

Frontiers in Cardiovascular Medicine, 2021
Objective: This study aimed to investigate the distribution of ideal cardiovascular health (ICH) indicators among the oldest-old and centenarians and explore their relationships with disability and health-related quality of life of this population ...
Miao Liu, Fuyin Kou, Shanshan Yang, Shengshu Wang, Yao He, Wuping Zhang   +5 more
doaj   +1 more source

A novel B cell population revealed by a CD38/CD24 gating strategy: CD38(-)CD24 (-) B cells in centenarian offspring and elderly people [PDF]

, 2013
The B cell arm of adaptive immunity undergoes significant modifications with age. Elderly people are characterized by impaired B cell responses reflected in a reduced ability to effectively respond against viruses and bacteria.
BUFFA, Silvio, BULATI, Matteo, CARUSO, Calogero, COLONNA ROMANO, Giuseppina, Goldeck, D, MARTORANA, Adriana, Pawelec, G, Pellicanò, M   +7 more
core   +1 more source

Sex differences in epigenetic age in Mediterranean high longevity regions

Frontiers in Aging, 2022
Sex differences in aging manifest in disparities in disease prevalence, physical health, and lifespan, where women tend to have greater longevity relative to men.
Hannah-Ruth Engelbrecht, Hannah-Ruth Engelbrecht, Hannah-Ruth Engelbrecht, Hannah-Ruth Engelbrecht, Sarah M. Merrill, Sarah M. Merrill, Sarah M. Merrill, Sarah M. Merrill, Nicole Gladish, Julie L. MacIsaac, Julie L. MacIsaac, Julie L. MacIsaac, David T. S. Lin, David T. S. Lin, David T. S. Lin, Simone Ecker, Christina A. Chrysohoou, Giovanni M. Pes, Michael S. Kobor, Michael S. Kobor, Michael S. Kobor, Michael S. Kobor, David H. Rehkopf   +22 more
doaj   +1 more source

Status and physiological significance of circulating adiponectin in the very old and centenarians: an observational study

eLife, 2023
Background: High levels of circulating adiponectin are associated with increased insulin sensitivity, low prevalence of diabetes, and low body mass index (BMI); however, high levels of circulating adiponectin are also associated with increased mortality ...
Takashi Sasaki, Yoshinori Nishimoto, Takumi Hirata, Yukiko Abe, Nobuyoshi Hirose, Michiyo Takayama, Toru Takebayashi, Hideyuki Okano, Yasumichi Arai   +8 more
doaj   +1 more source

Allelic distribution of ABO gene in Chinese centenarians

Aging Medicine, 2020
Objective Human ABO blood groups are determined by the alleles A, B, and O (O01 and O02) of the ABO gene and have been linked to the risks for cardiovascular diseases and cancers that affect lifespan.
Ying Zhu, Yu Liang, Abdul Haseeb Khan, Minghua Dong, Yiqi Wan, Zhichao Sun, Yi Zeng, Chao Nie, Xiao‐Li Tian   +8 more
doaj   +1 more source

The well-being of community-dwelling near-centenarians and centenarians in Hong Kong a qualitative study [PDF]

, 2014
published_or_final_versio
Chan, MYG, Chan, WM, Cheung, KSL, Kwok, NCF, Lau, HP, Leung, AYM, Wong, PWC   +6 more
core   +1 more source