Results 61 to 70 of about 3,476 (178)
Staging concept for aging management: Definition, mechanism, and coping strategies
VIEW, Volume 7, Issue 4, August 2026.We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang +6 more
wiley +1 more source
Neuropathology in a diverse cohort of oldest‐old: The LifeAfter90 study
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract INTRODUCTION Studies of the oldest‐old show great neuropathologic heterogeneity; little is known in diverse populations after age 90. METHODS LifeAfter90 is a lifecourse cohort study of individuals aged ≥ 90 years evaluated every 6 months with optional brain donation; this study presents initial neuropathological findings.
Brittany N. Dugger +9 more
wiley +1 more source
Neuropathology of the centenarian brains
Alzheimer Disease & Associated Disorders, 1985 100歳から115歳にわたる5例の長寿者の脳を病理学的に検討した.1) 症例はいずれも女性で, 従来ほとんど病気らしい病気をせず, 比較的長寿の家系のものが多い.2) 精神機能の障害は死亡の数年以内に目立ってきている.3) 死因は, 肺炎, 心不全, 肺癌, その他である.4) 全身臓器の著明な萎縮があり, 脳重は950～1,170gで, 全葉に回転萎縮がみられた.5) 脳に肉眼的粗大病変のあるものは3例で, 出血, 梗塞とも小さなものであった.6) 組織学的には, 生理的老年変化と関連した神経細胞数の減少, 萎縮, リポフスチン沈着, 軸索ジストロフィー, マリネスコ小体, トルペドーなどはいずれも高度であった.
M, Tomonaga, M, Yoshimura
openaire +3 more sources
Caenorhabditis elegans and Drosophila melanogaster as Model Organisms in Biofactor Research
BioFactors, Volume 52, Issue 4, July/August 2026.This review presents Caenorhabditis elegans and Drosophila melanogaster as powerful and ethically sound invertebrate model organisms that can be used to investigate nutritional science questions relating to biofactors. Such nutritional phenotyping studies can bridge the gap between in vitro studies and in vivo research in mammals.
Kai Lüersen +2 more
wiley +1 more source
Endovascular abdominal aortic aneurysm repair in a centenarian
Journal of Vascular Surgery Cases and Innovative Techniques, 2020 As the general population ages, there will be an increasing number of vascular patients in their 90s and older. However, geriatric patients have historically been turned down for abdominal aortic aneurysm repair despite high aneurysm-related mortality in
Kirthi S. Bellamkonda, MSc +4 more
doaj +1 more source
Inflammaging: Experimental Insights and Translational Advances
European Journal of Immunology, Volume 56, Issue 7, July 2026.Inflammaging is a chronic, low‐grade, sterile inflammation associated with aging that contributes to age‐related diseases and functional decline. Recent research suggests that targeting inflammaging through senolytics, metabolic modulators, microbiome‐based interventions, and lifestyle modifications may help improve healthspan, reduce chronic disease ...
Andrea Cossarizza
wiley +1 more source
Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers
MedComm, Volume 7, Issue 7, July 2026.This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai +10 more
wiley +1 more source
New estimates of Australia’s centenarian population
International Journal of Population Data Science, 2018 Introduction: The population of Australia at the very highest ages is growing rapidly, like that of many countries. But official population estimates at these ages are of lower quality than those at younger ages, a problem shared by many countries which ...
Tom Wilson, Wilma Terblanche
doaj +1 more source
Journal of Inflammation Research, 2022 Long Feng,1,* Di Wu,2,* Ping Ping,3,* Jieqiong Lin,4,* Yali Zhao,5 Yao Yao,6,7 Pei Zhang,8 Shihui Fu2,9 1Department of Anesthesiology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, People’s Republic of China;
Feng L +7 more
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