Results 41 to 50 of about 7,584 (174)

Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians

BMC Medical Genomics, 2018
Background Human aging is a hot topic in biology, and it has been associated with DNA methylation changes at specific genomic sites. We aimed to study the changes of DNA methylation at a single-CpG-site resolution using peripheral blood samples from ...
Qian Zeng, Xiaoping Chen, Chaoxue Ning, Qiao Zhu, Yao Yao, Yali Zhao, Fuxin Luan   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

“I Have Never Visited a Health Center”: Ethiopian Centenarians’ Perceptions of Their Health Conditions

Journal of Ageing and Longevity
The global centenarian population is expected to reach 4 million by 2050, yet little is known about the health status of centenarians in Sub-Saharan Africa. A case study examined the health conditions and functionality of nine Ethiopian centenarians.
Samson Chane, Margaret E. Adamek
doaj   +1 more source

Health of Spanish centenarians: a cross-sectional study based on electronic health records

BMC Geriatrics, 2019
Background With the number of centenarians increasing exponentially in Spain, a deeper knowledge of their socio-demographic, clinical, and healthcare use characteristics is important to better understand the health profile of the very elderly. Methods We
Antonio Gimeno-Miguel, Mercedes Clerencia-Sierra, Ignatios Ioakeim, Beatriz Poblador-Plou, Mercedes Aza-Pascual-Salcedo, Francisca González-Rubio, Raquel Rodríguez Herrero, Alexandra Prados-Torres   +7 more
doaj   +1 more source

The practicality of different eGFR equations in centenarians and near-centenarians: which equation should we choose? [PDF]

PeerJ, 2020
Background No studies have examined the practicality of the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiological Collaboration (CKD-EPI) and Berlin Initiative Study 1 (BIS1) equations for the estimated glomerular ...
Qiuxia Han, Dong Zhang, Yali Zhao, Liang Liu, Jing Li, Fu Zhang, Fuxin Luan, Jiayu Duan, Zhangsuo Liu, Guangyan Cai, Xiangmei Chen, Hanyu Zhu   +11 more
doaj   +2 more sources

Modular Control of PEG‐Poly(2‐Oxazoline) Co‐Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management

Advanced Healthcare Materials, EarlyView.
A thermo‐responsive poly(2‐oxazoline)‐based injectable formulation is developed to modulate intraocular pressure (IOP) in both normal and hypotonic eyes. By adjusting the PEG content, the aggregation behavior is finely tuned, enabling IOP elevation without long‐term deposition.
Yuji Tanaka, Shohei Morikawa, Shigehito Osawa   +2 more
wiley   +1 more source

Associations between cardiac structure and function and depressive disorder: A centenarian study in China

Heliyon, 2023
Background: Depressive disorder is a common comorbidity in patients with cardiovascular diseases and is associated with increased hospitalization and death rates.
Zhigao Sun, Ping Ping, Pei Zhang, Yao Yao, Zhenjun Huang, Yali Zhao, Leiming Luo, Shihui Fu   +7 more
doaj   +1 more source

Body donor programs in Australia and New Zealand: Current status and future opportunities

Anatomical Sciences Education, Volume 18, Issue 3, Page 301-328, March 2025.
Abstract Body donation is critical to anatomy study in Australia and New Zealand. Annually, more than 10,000 students, anatomists, researchers, and clinicians access tissue donated by local consented donors through university‐based body donation programs. However, little research has been published about their operations.
Rebekah A. Jenkin, Kevin A. Keay
wiley   +1 more source

The Genetics of Extreme Longevity: Lessons from the New England Centenarian Study

Frontiers in Genetics, 2012
The New England Centenarian Study (NECS) was founded in 1994 as a longitudinal study of centenarians to determine if centenarians could be a model of healthy human aging. Over time, the NECS along with other centenarian studies have demonstrated that the
Paola eSebastiani, Thomas T Perls
doaj   +1 more source

The human foundations of anatomy at The University of Sydney: One hundred and one years of body procurement

Anatomical Sciences Education, EarlyView.
Abstract Body procurement at The University of Sydney has a long history. Anatomy legislation (1881 Anatomy Act) modeled on the British Anatomy Act 1832 legalized procurement of unclaimed bodies from public institutions for anatomical dissection at licensed Schools of Anatomy, effectively conferring the University of Sydney an exclusive license until ...
Rebekah A. Jenkin, Kevin A. Keay
wiley   +1 more source