Results 41 to 50 of about 11,258 (207)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A survey on hearing acuity of centenarians in Hainan Province

Journal of Otology, 2018
Objective: This study aimed to investigate hearing acuity of centenarians in Hainan Province and provide basis for interventional considerations. Method: Door-to-door follow-up was conducted to investigate hearing acuity of centenarians (aged 100 years ...
Jianhui Li, Hui Zhao, Bangqing Huang, Shanshan Zhang, Kaihua Sun, Xinying Jiang, Fuxin Luan   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Oral health and functional capacity of centenarians

Scientific Reports, 2020
The number of very old individuals, namely centenarians, is growing fast. In dentistry, the increasing number of older adults retaining natural teeth present new challenges for preventive and restorative dental care. However, there is a considerable lack
Caroline Sekundo, Eva Langowski, Samuel Kilian, Cornelia Frese   +3 more
doaj   +1 more source

Comparison of functional disabilities, place of death and end-of-life medical expenditures among centenarians and non-centenarians in China: a series of cross-sectional studies

BMC Geriatrics, 2023
Background Long-term and end-of-life (EOL) care for older adults has become a global concern due to extended longevity, which is generally accompanied by increased rates of disability.
Zhong Li, Ziqin Ding, Panpan Zhao
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Five gene variants in nonagenarians, centenarians and average individuals

, 2017
Introduction: Genetic factors contribute to the variation of human life span which is believed to be more profound after 85 years of age. The aim of the present study was to evaluate the frequency of 5 gene polymorphisms between nonagenarians ...
Markos Kouris, Niki Katsiki, Constantinos Mihas, Genovefa Kolovou, Vana Kolovou, Helen Bilianou, Petros Kalogeropoulos, Maria Boutsikou, Ioannis Hoursalas, Sophie Mavrogeni, Dennis V. Cokkinos, Vasiliki Giannakopoulou   +11 more
core   +1 more source

Thyroid hormones in centenarians in coronary artery disease

, 2023
Aim. To analyze the relationship of thyroid hormones with various clinical and laboratory parameters in centenarians with coronary artery disease (CAD) based on the determination of the blood concentration of thyroid-stimulating hormone (TSH), free ...
Tatyana M. Kolontai, Tatyana A. Eliseeva, Georgii G. Melkonyan, Margarita A. Romanova, Olga N. Vakulenko, Leonid I. Dvoretsky, Olga I. Turna, Karine A. Lytkina, Svetlana V. Topolyanskaya, Leonid I. Bubman, Svetlana A. Ratchina   +10 more
core   +1 more source

Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans [PDF]

, 2021
Using samples from the New England Centenarian Study (NECS), we sought to characterize the serum proteome of 77 centenarians, 82 centenarians' offspring, and 65 age-matched controls of the offspring (mean ages: 105, 80, and 79 years).
Anthony Federico, Kevin B. Chandler, TOSHIKO, TANAKA, Chandler, Kevin B., Gerald Denis, Luigi Ferrucci, David J. Glass, BHUTKAR, APARNA, Melody Morris, Stefano Monti, Morris, Melody, Thomas T. Perls, Jennings, Lori, FERRUCCI, LUIGI, Paola Sebastiani, FEDERICO, ANTHONY, Stacy L. Andersen, Glass, David, Perls, Thomas T., MONTI, STEFANO, Denis, Gerald, ANDERSON, STACY L, PERLS, THOMAS T, Lori Jennings, Tanaka, Toshiko, Glass, David J., Toshiko Tanaka, Costello, Catherine E., SEBASTIANI, PAOLA, GURINOVICH, ANASTASIA, Andersen, Stacy L., Anastasia Gurinovich, Catherine E. Costello   +32 more
core   +1 more source

Centenarian physical functioning evolution and COVID-19 impact: A study in Japan

JAR Life
Background: Studies show that centenarians' physical function and activities of daily living (ADL) levels improved recently. However, it is unclear whether this positive impact has been altered due to COVID-19, causing reduced ADL.
Xinyu Zhang, Jean-Marie Robine, Yasuyuki Gondo   +2 more
doaj   +1 more source