Results 51 to 60 of about 11,258 (207)
Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians
BMC Medical Genomics, 2018 Background Human aging is a hot topic in biology, and it has been associated with DNA methylation changes at specific genomic sites. We aimed to study the changes of DNA methylation at a single-CpG-site resolution using peripheral blood samples from ...
Qian Zeng +6 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Journal of Ageing and LongevityThe global centenarian population is expected to reach 4 million by 2050, yet little is known about the health status of centenarians in Sub-Saharan Africa. A case study examined the health conditions and functionality of nine Ethiopian centenarians.
Samson Chane, Margaret E. Adamek
doaj +1 more source
Health of Spanish centenarians: a cross-sectional study based on electronic health records
BMC Geriatrics, 2019 Background With the number of centenarians increasing exponentially in Spain, a deeper knowledge of their socio-demographic, clinical, and healthcare use characteristics is important to better understand the health profile of the very elderly. Methods We
Antonio Gimeno-Miguel +7 more
doaj +1 more source
Body donor programs in Australia and New Zealand: Current status and future opportunities
Anatomical Sciences Education, Volume 18, Issue 3, Page 301-328, March 2025.Abstract Body donation is critical to anatomy study in Australia and New Zealand. Annually, more than 10,000 students, anatomists, researchers, and clinicians access tissue donated by local consented donors through university‐based body donation programs. However, little research has been published about their operations.
Rebekah A. Jenkin, Kevin A. Keay
wiley +1 more source
Calcium metabolism and vitamin D in the extreme longevity
, 2008 Skeletal remodelling is a continuous process during life and is still active also in extreme senescence. In the elderly, bone resorption often prevails over bone formation, causing bone loss and fragility.
G. Passeri +7 more
core +1 more source
The Genetics of Extreme Longevity: Lessons from the New England Centenarian Study
Frontiers in Genetics, 2012 The New England Centenarian Study (NECS) was founded in 1994 as a longitudinal study of centenarians to determine if centenarians could be a model of healthy human aging. Over time, the NECS along with other centenarian studies have demonstrated that the
Paola eSebastiani, Thomas T Perls
doaj +1 more source
Association Characteristics and Potential Mechanisms of Aging, Gut Microbiota, and Hearing Loss
Integrative Zoology, EarlyView.The study found that aging leads to unchanged gut microbiota alpha diversity but an increase in Bacteroidetes and a decrease in Firmicutes at the phylum level, with specific genera, species, and functional pathways co‐associated with aging and hearing loss. Through constructing a microbe‐metabolite network, it revealed the mechanism by which protective
Cheng Cheng +7 more
wiley +1 more source
Environmental support among centenarians
, 2021 Centenarians are a unique group of individuals, outliving the general population by many years. Although their extraordinary life span is an individual achievement, it is unlikely that centenarians reach such an old age without sufficient environmental ...
Martin, Peter +2 more
core
Heliyon, 2023 Background: Depressive disorder is a common comorbidity in patients with cardiovascular diseases and is associated with increased hospitalization and death rates.
Zhigao Sun +7 more
doaj +1 more source