Results 61 to 70 of about 7,584 (174)
Neuropathology of the centenarian brains
Alzheimer Disease & Associated Disorders, 1985 100歳から115歳にわたる5例の長寿者の脳を病理学的に検討した.1) 症例はいずれも女性で, 従来ほとんど病気らしい病気をせず, 比較的長寿の家系のものが多い.2) 精神機能の障害は死亡の数年以内に目立ってきている.3) 死因は, 肺炎, 心不全, 肺癌, その他である.4) 全身臓器の著明な萎縮があり, 脳重は950～1,170gで, 全葉に回転萎縮がみられた.5) 脳に肉眼的粗大病変のあるものは3例で, 出血, 梗塞とも小さなものであった.6) 組織学的には, 生理的老年変化と関連した神経細胞数の減少, 萎縮, リポフスチン沈着, 軸索ジストロフィー, マリネスコ小体, トルペドーなどはいずれも高度であった.
M, Tomonaga, M, Yoshimura
openaire +3 more sources
Caenorhabditis elegans and Drosophila melanogaster as Model Organisms in Biofactor Research
BioFactors, Volume 52, Issue 4, July/August 2026.This review presents Caenorhabditis elegans and Drosophila melanogaster as powerful and ethically sound invertebrate model organisms that can be used to investigate nutritional science questions relating to biofactors. Such nutritional phenotyping studies can bridge the gap between in vitro studies and in vivo research in mammals.
Kai Lüersen +2 more
wiley +1 more source
mSystems, 2019 Sardinia, Italy, has a high prevalence of residents who live more than 100 years. The reasons for longevity in this isolated region are currently unknown. Gut microbiota may hold a clue.
Lu Wu +5 more
doaj +1 more source
Inflammaging: Experimental Insights and Translational Advances
European Journal of Immunology, Volume 56, Issue 7, July 2026.Inflammaging is a chronic, low‐grade, sterile inflammation associated with aging that contributes to age‐related diseases and functional decline. Recent research suggests that targeting inflammaging through senolytics, metabolic modulators, microbiome‐based interventions, and lifestyle modifications may help improve healthspan, reduce chronic disease ...
Andrea Cossarizza
wiley +1 more source
Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers
MedComm, Volume 7, Issue 7, July 2026.This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai +10 more
wiley +1 more source
BMC Genomics, 2007 Background Studies on heteroplasmy occurring in the mitochondrial DNA (mtDNA) control region (CR) in leukocytes of centenarians and younger subjects have shown that the C150T somatic transition is over-represented in centenarians.
Maletta Raffaele +11 more
doaj +1 more source
Frontiers in Endocrinology, 2018 As the first time worldwide, this study aimed to investigate the relationships of hyperhomocysteinemia and hyperuricemia with metabolic syndrome (MetS) and renal function in Chinese centenarians. The China Hainan Centenarian Cohort Study was performed in
Shihui Fu +5 more
doaj +1 more source
Functional capacity and level of physical activity in centenarians of Florianópolis, Brazil
Revista da Educação Física, 2016 Aim: To compare the level of physical activity and functional capacity of centenarians from Florianópolis, Brazil. Methods: To measure the level of physical activity and functional capacity, pedometer and the Katz scale, respectively, were used.
Inês Amanda Streit +3 more
doaj
iMetaA better understanding of the characteristic serum metabolites and microbiota from the gut and oral cavity in centenarians could contribute to elucidating the mutual connections among them and would help provide information to achieve healthy longevity ...
Xiaorou Qiu +16 more
doaj +1 more source
Lipid profile in elderly and centenarian subjects in Kazakhstan: a case-control study
Central Asian Journal of Medical Hypotheses and EthicsIntroduction. The health of centenarians is a major focus in global studies. Dyslipidemia is directly linked to the risk of cardiovascular diseases, which pose a growing burden on healthcare due to the increasing elderly population.
Yu. Ganzhula +4 more
doaj +1 more source