Results 61 to 70 of about 11,258 (207)

Habitual fasting duration and accelerated multimorbidity in older adults

Journal of Internal Medicine, EarlyView.
Abstract Background Prolonged fasting has been linked to metabolic benefits in younger adults, but its effects on chronic diseases in older populations remain unclear. Objective To examine the association between habitual fasting duration and 15‐year chronic disease accumulation in older adults, overall, within organ systems, and between age groups ...
Luis Kalmbach, David Abbad‐Gomez, Giorgi Beridze, Fernando Rodríguez‐Artalejo, Davide Liborio Vetrano, Amaia Calderón‐Larrañaga, Adrián Carballo‐Casla   +6 more
wiley   +1 more source

Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians

, 2021
Oxidative stress is an important factor in age-associated neurodegeneration. Accordingly, mitochondrial dysfunction and genomic instability have been considered as key hallmarks of aging and have important roles in age-associated cognitive decline and ...
Sanchez-Roman, Ines, Holst, Camilla Myrup, Thinggaard, Mikael, Ferrando, Beatriz, Rasmussen, Signe Hoej, Christensen, Kaare, Bohr, Vilhelm A, Stevnsner, Tinna V., Bohr, Vilhelm A., Mengel-From, Jonas, Mengel‑From, Jonas, Stevnsner, Tinna, Sánchez‑Román Rojas, Inés, Rasmussen, Signe Høi, Christensen, Kaare; id_orcid, Sánchez-Román Rojas, Inés, Thinggaard, Mikael; id_orcid   +16 more
core   +1 more source

A demographic perspective on longevity and healthspan: Rethinking population ageing through a positive and prospective lens

Journal of Internal Medicine, EarlyView.
Abstract Population ageing is portrayed as a threat to the sustainability of health and welfare systems. This narrative—grounded in static chronological definitions of old age—risks overstating the burden of increasing longevity while overlooking changes in survival, health and population composition. In this article, we adopt a demographic perspective
Daniele Vignoli, Cosmo Strozza, Agar Brugiavini, Davide Liborio Vetrano, Amaia Calderón‐Larrañaga, Serhiy Dekhtyar, Pietro Grassi, Chiara Seghieri   +7 more
wiley   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Co‐pathologies – including Lewy body, vascular, and TDP‐43 lesions – are common in Alzheimer's disease (AD), contributing to its clinical and pathological heterogeneity. Genetic risk factors may drive mixed pathology presentation, but their influence on the development of specific co‐pathologies remains unclear.
Madison M. Reeves, Anna Calliari, Tiffany W. Todd, Candela Maroto Cidfuentes, Karen Jansen‐West, Mei Yue, Yuping Song, Judith Dunmore, Bailey Rawlinson, Erica Engelberg‐Cook, Michael DeTure, Gregory S. Day, Neill R. Graff‐Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Casey N. Cook, Melissa E. Murray, Dennis W. Dickson, Keith A. Josephs, Leonard Petrucelli, Mercedes Prudencio   +21 more
wiley   +1 more source

Centenarians, semi and supercentenarians, COVID-19 and Spanish flu: a serological assessment to gain insight into the resilience of older centenarians to COVID-19

Immunity & Ageing
Background Although it is well known that the older people have been the most susceptible to COVID-19, there are conflicting data on the susceptibility of centenarians.
Claudia Maria Trombetta, Giulia Accardi, Anna Aiello, Anna Calabrò, Calogero Caruso, Mattia Emanuela Ligotti, Serena Marchi, Emanuele Montomoli, Martin Mayora Neto, Nigel Temperton, Giuseppina Candore   +10 more
doaj   +1 more source

Hippocampal snRNA‐seq in Collaborative Cross reveals molecular signatures of cognitive resilience independent of chronological aging

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Genetic factors contribute to variability in age‐related cognitive decline, yet the molecular mechanisms underlying cognitive resilience remain poorly understood. METHODS We performed single‐nucleus RNA sequencing on hippocampal tissue from 107 genetically diverse Collaborative Cross mice across three ages (6, 12, and 18 months ...
Yu Chen, Andrew R. Ouellette, Yiding Cao, Jigang Zhang, Catherine C. Kaczorowski   +4 more
wiley   +1 more source

The human foundations of anatomy at The University of Sydney: One hundred and one years of body procurement

Anatomical Sciences Education, Volume 19, Issue 9, Page 1491-1511, September 2026.
Abstract Body procurement at The University of Sydney has a long history. Anatomy legislation (1881 Anatomy Act) modeled on the British Anatomy Act 1832 legalized procurement of unclaimed bodies from public institutions for anatomical dissection at licensed Schools of Anatomy, effectively conferring the University of Sydney an exclusive license until ...
Rebekah A. Jenkin, Kevin A. Keay
wiley   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, Volume 3, Issue 3, September 2026.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

A Mechanism‐Based Framework for Anti‐Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell‐Based Interventions

Aging Cell, Volume 25, Issue 9, September 2026.
The aging of the human body is a complex process driven by multiple contributing factors. Based on their underlying mechanisms, current anti‐aging interventions can be classified into six primary categories. This paper summarizes the most promising anti‐aging strategies within each class. ABSTRACT The global prevalence of aging and age‐related diseases
Feifei Li, Yankai Wang, Gelin Wang, Jiguo Chen, Song Huang   +4 more
wiley   +1 more source