Results 71 to 80 of about 11,258 (207)

Midlife Growth Hormone Receptor Ablation Extends Healthy Lifespan and Induces Sex‐Specific Hepatic Transcriptional Changes at Single‐Cell Resolution

Aging Cell, Volume 25, Issue 9, September 2026.
Reducing growth hormone receptor signaling beginning in middle age is sufficient to extend lifespan in both sexes while preserving metabolic and physical function, particularly in males. Single‐nucleus RNA sequencing reveals sex‐specific hepatic transcriptional remodeling associated with these longevity benefits. ABSTRACT Suppression of growth hormone (
Silvana Duran‐Ortiz, Edward O. List, Jonathan A. Young, Yuji Ikeno, Shouan Zhu, Todd McHugh, Patrick M. O'Connor, Minhoo Kim, Bérénice A. Benayoun, Fabian Benencia, Reetobrata Basu, Emmanuel A. Gotte, Darlene E. Berryman, John J. Kopchick   +13 more
wiley   +1 more source

The number of centenarians in Brazil: Indirect estimates based on death certificates [PDF]

The Brazilian population is rapidly aging. As a result, the number of centenarians has grown steadily, about 77 per cent between 1991 and 2000. Although expected, the increasing number of centenarians may be exaggerated by data quality issues. We compare
Cassio M. Turra, Marilia Miranda Fortes Gomes   +1 more
core  

Haitian Centenarians: An Undocumented Phenomenon

, 2020
A ceaselessly neglected phenomenon until recent years, especially in developing countries, centenarians bring unique wisdom, perspective, history and science to our society based on their lived experiences.
Dasilma, Erna
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Land of Centenarians [PDF]

, 1984
Land of Centenarians Brown C ...

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Hypertension, but Not Cancer or Obesity, Is Compatible With Extreme Longevity: A Multi‐Institution Analysis of 733,919 US Centenarians

Journal of the American Geriatrics Society, EarlyView.
Fateme Nateghi Haredasht, Kameron C. Black, Chukwuebuka Anyaegbuna, Stephen P. Ma, Vyjeyanthi S. Periyakoil, Jonathan H. Chen   +5 more
wiley   +1 more source

Akkermansia muciniphila and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging

Aging Cell, Volume 25, Issue 9, September 2026.
The beneficial gut bacterium Akkermansia muciniphila (AKK) declines with age but is enriched in healthy centenarians. Supplementation of AKK extends healthspan and alleviates age‐related decline through direct host–microbe interactions and its bioactive derivatives, which collectively enhance gut barrier integrity, restore metabolic homeostasis ...
Ting Zhang, Jinyuan Niu, Xiaoyu Hu, Zhiang Hu, Yuan Gao, Jialiang Liu, Ning Chen, Yaomin Hu   +7 more
wiley   +1 more source

Laboratory parameters of italian centenarians [PDF]

, 1998
A consortium of 20 university departments of geriatrics and gerontology conducted the Italian Multicentric Study on Centenarians (IMSC), in order to assess the socio-economic, clinical and biological conditions of the Italian centenarians.
R. Rapisarda, M. Agretti, A. Franzone, F. Duca, P. Ferrazzi, E. Bosi, A. Capurso, E. Petruzzi, P. Costelli, S. Bertolini, R. Mattace, M. Trabucchi, G. Masotti, M. Manzoni, A. M. Colacicco, A. Gaddi, C. Galletti, S. Daddato, L. Motta, M. Motta, L. Pansini, D. Mari, R. Rozzini, S. Boffelli, N. Marchionni, V. Solfrizzi   +25 more
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Centenarians In The Global South: A View From Ethiopia

, 2021
As global aging advances, the number of centenarians worldwide is greatly increasing. Most of what is known about centenarians comes the Global North.
Adamek, Margaret, Chane, Samson
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Coronal and Root Caries in Older Adults: Associated Factors, Quality of Life Impact, and Treatment—A Scoping Review

Gerodontology, Volume 43, Issue 3, Page 306-317, September 2026.
ABSTRACT Background Dental caries remains one of the most common chronic diseases affecting older adults worldwide. As edentulism decreases and more natural teeth are retained into old age, the number of susceptible tooth surfaces increases. Age‐related factors such as polypharmacy, cognitive decline, and reduced oral hygiene skills, together with ...
Helena Dujic, Katrin Heck, Julia Schwärzler, Cristiane da Mata, Sayaka Tada, Falk Schwendicke   +5 more
wiley   +1 more source

Centenarians overexpress pluripotency-related genes [PDF]

Human mesenchymal cells can become pluripotent by the addition of Yamanaka factors OCT3/4, SOX2, c-MYC, KLF4. We have recently reported that centenarians overexpress BCL-xL, which has been shown to improve pluripotency; thus, we aimed to determine the ...
Sanchís, Paula, Matheu, Ander, Berna-Erro, Alejandro, Borrás Blasco, Consuelo, Mas Bargues, Cristina, Inglés de la Torre, Marta, Viña Ribes, José, Avellana Zaragoza, Juan Antonio   +7 more
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