Results 121 to 130 of about 759,357 (305)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Issued as a Documentation Report on an Investigation of Field-Made Joints in Prestressed Reinforced Concrete Highway Girder Bridges, Project IHR-303, Phase 2 [PDF]
, 1977 A prototype bridge girder was designed, built, and tested. The 250 ft long two-span girder was made of 3 precast segments about 88, 74, and 88 ft in length. The segments were supported on 3 final and 2 temporary supports.
Fadl, Abdullahi Ibrahim +2 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Biotecnología Vegetal, 2020 In Cuba, a biofertilizer has been developed based on a nitrogen fixer Azotobacter chroococcum strain. This work aimed to optimize the culture medium and the fermentation conditions for industrial scale.
María Cristina Pérez Peñaranda +4 more
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Sensitivity analysis and optimization of system dynamics models: Regression analysis and statistical design of experiments [PDF]
This tutorial discusses what-if analysis and optimization of System Dynamics models. These problems are solved, using the statistical techniques of regression analysis and design of experiments (DOE).
Kleijnen, J.P.C.
core +1 more source
Generic composite flywheel designs [PDF]
, 1984 Fiber reinforced composites belong to a new class of materials and allow great flexibility in flywheel design. The most efficient flywheel may no longer have the classic Stodola taper and indeed, may not even be round.
Steele, R. S.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Central composite design for the removal of copper by an Adansonia digitata
Desalination and Water TreatmentBiosorption, an alternative to traditional methods such as precipitation, ion exchange, electrochemical treatment, and evaporative recovery, is being considered as a potential means for removing heavy toxic metals from waste solution.
Naveen Prasad +6 more
doaj +1 more source