Results 121 to 130 of about 198,147 (243)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Carbon-nitrogen interaction controls postbiotic short-chain fatty acid spectrum in a bacterial-yeast consortium: a central composite design approach. [PDF]

Vet World
Marlida Y, Anggraini L, Shun TJ, Syofyan S, Dwitaviani R, Ardani LR, Bagaskaraell TA.   +6 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Optimization of Phenolic and Flavonoid Extraction From Bee Bread Using Response Surface Methodology and Central Composite Design, and Evaluation of Antimicrobial Activity. [PDF]

Food Sci Nutr
Keyvan N, Kaya MM, Demirağ MS, Bayezit M, Tutun H, Kahraman HA, Keyvan E.   +6 more
europepmc   +1 more source

Application of Central Composite Design and Superimposition Approach for Optimization of Drying Parameters of Pretreated Cassava Flour. [PDF]

Foods, 2023
Nainggolan EA, Banout J, Urbanova K.
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Modeling and optimization of Multi-Waste foam geopolymers using central composite design and neural networks. [PDF]

Sci Rep
Noui A, Belkadi AA, Berkouche A, Alsuhaibani E, Alomayri T, Dridi M, Douadi A.   +6 more
europepmc   +1 more source

Intensification and Optimization of FAME Synthesis via Acid-Catalyzed Esterification Using Central Composite Design (CCD). [PDF]

ACS Omega, 2023
Saeed AMM, Sharma S, Hassan SZ, Ghaleb AM, Cao GP.   +4 more
europepmc   +1 more source

Design And Development of Emulgel Containing Ibuprofen Using Central Composite Design

Ibuprofen is chosen as the drug in the emulgel.  Emulgel accommodates oil soluble drugs and enhances penetration of the drug. Ibuprofen (iso-butyl-phenyl-propionic acid) is a nonsteroidal anti-inflammatory drug (NSAID) that is used for treating pain, fever, and inflammation. Peceol oil is chosen in emulgel .
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source