Results 251 to 260 of about 759,357 (305)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Quantitative assessment and optimization of parallel contact model for flexible paddy straw: a definitive screening and central composite design approach using discrete element method. [PDF]

Sci Rep
Patel A, Singh KP, Roul AK, Nalawade RD, Mahore A, Kumar M, Avilala P, Ramulu C, Kebede B, Patra A.   +9 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Formulation Development of Solid Self-Nanoemulsifying Drug Delivery Systems of Quetiapine Fumarate via Hot-Melt Extrusion Technology: Optimization Using Central Composite Design. [PDF]

Pharmaceutics
Uttreja P, Youssef AAA, Karnik I, Sanil K, Narala N, Wang H, Elkanayati RM, Vemula SK, Repka MA.   +8 more
europepmc   +1 more source

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Repairing Non-rotatable Central Composite Designs

Journal of Statistical Theory and Practice, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
E. U. Ohaegbulem, P. E. Chigbu
openaire   +2 more sources

Slope-Rotatable Central Composite Designs

Technometrics, 1978
An analogue of the Box-Hunter rotatability property for second order response surface designs in k independent variables is presented. When such designs are used to estimate the first derivatives with respect to each independent variable the variance of the estimated derivative is a function of the coordinates of the point at which the derivative is ...
R. J. Hader, Sung H. Park
openaire   +1 more source

Study of Central Composite Design and Orthogonal Array Composite Design

2020
Response surface methodology (RSM) is an effective tool for exploring the relationships between the response and the input factors. Central composite design (CCD) and orthogonal array composite design (OACD) are useful second-order designs in response surface methodology.
Si Qiu, Minyu Xie, Hong Qin, Jianhui Ning   +3 more
openaire   +1 more source