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Formulation Development of Solid Self-Nanoemulsifying Drug Delivery Systems of Quetiapine Fumarate via Hot-Melt Extrusion Technology: Optimization Using Central Composite Design. [PDF]

Pharmaceutics
Uttreja P, Youssef AAA, Karnik I, Sanil K, Narala N, Wang H, Elkanayati RM, Vemula SK, Repka MA.   +8 more
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Repairing Non-rotatable Central Composite Designs

Journal of Statistical Theory and Practice, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
E. U. Ohaegbulem, P. E. Chigbu
openaire   +2 more sources

A measure of orthogonality for the central composite designs

Communications in Statistics - Theory and Methods, 2021
A measure that quantifies the percent orthogonality of the central composite designs is proposed.
Emmanuel Uchenna Ohaegbulem, Polycarp Emeka Chigbu   +1 more
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Assessing the percent rotatability of the central composite designs

Communications in Statistics - Theory and Methods, 2021
A measure of quantifying the percent rotatability, specifically for the Central Composite Designs (CCDs), is proposed.
Emmanuel Uchenna Ohaegbulem, Polycarp E. Chigbu   +1 more
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Design and Optimization of 3D-Printed Gastroretentive Floating Devices by Central Composite Design

AAPS PharmSciTech, 2021
This study aimed to optimize the size of capsule-shaped 3D-printed devices (CPD) using an experimental design by the response surface methodology to provide a gastroretentive drug delivery system (GRDDS) with optimal floating time. The CPD was fabricated using a fused deposition modeling (FDM) 3D printer.
Thapakorn, Charoenying, Prasopchai, Patrojanasophon, Tanasait, Ngawhirunpat, Theerasak, Rojanarata, Prasert, Akkaramongkolporn, Praneet, Opanasopit   +5 more
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Very large fractional factorial and central composite designs

ACM Transactions on Modeling and Computer Simulation, 2005
We present a concise representation of fractional factorials and an algorithm to quickly generate resolution V designs. The description is based on properties of a complete, orthogonal discrete-valued basis set called Walsh functions. We tabulate two-level resolution V fractional factorial designs, as well as central composite designs allowing ...
Sanchez, S.M., Sanchez, P.J.
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Study of Central Composite Design and Orthogonal Array Composite Design

2020
Response surface methodology (RSM) is an effective tool for exploring the relationships between the response and the input factors. Central composite design (CCD) and orthogonal array composite design (OACD) are useful second-order designs in response surface methodology.
Si Qiu, Minyu Xie, Hong Qin, Jianhui Ning   +3 more
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Slope-Rotatable Central Composite Designs

Technometrics, 1978
An analogue of the Box-Hunter rotatability property for second order response surface designs in k independent variables is presented. When such designs are used to estimate the first derivatives with respect to each independent variable the variance of the estimated derivative is a function of the coordinates of the point at which the derivative is ...
R. J. Hader, Sung H. Park
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A Central Composite Design to Investigate the Thermal Stabilization of Lysozyme

Pharmaceutical Research, 1999
The formulation and processing of protein drugs requires the stabilization of the native, biologically active structure. Our aim was to investigate the thermal stability of a model protein, lysozyme, in the presence of two model excipients, sucrose and hydroxypropyl-beta-cyclodextrin (HP-beta-CD).We used high sensitivity differential scanning ...
S, Branchu, R T, Forbes, P, York, H, Nyqvist   +3 more
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