Results 81 to 90 of about 215,784 (311)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Application of Central Composite Design to Optimize Spawns Propagation

Open Journal of Optimization, 2020
Despite the increased recognition of the nutritional value of the Oyster mushroom, coupled with its ability to tolerate a wide range of climatic conditions, its production is still at infancy stage with low adoption rate in Kenya. The low uptake could be attributed to the cost of spawns or lack of skills for spawns preparations coupled with poor ...
Kasina, Martin M., Koske, Joseph, Mutiso, John   +2 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The conceptual design changes triggered by timber boards [PDF]

, 2011
After the introduction of timber boards as diaphragms in light-frame construction opened the way to modern timber construction, three major design changes would follow: the elements become multifunctional, they can work structurally in two directions ...
Costa Santos, Sandra; id_orcid, Costa Santos, Sandra   +1 more
core  

Optimization of Electrical Discharge Machining Parameters of Co-Cr-Mo Using Central Composite Design

, 2017
The optimization of electrical discharge machining (EDM) parameters of Cobalt Chromium Molybdenum (Co-Cr-Mo) is performed using central composite design to improve the process efficiency in terms of increasing material removal rate and electrode ...
Alireza Esmaeilzadeh, Soudeh Iranmanesh, Abbas Razavykia   +2 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Optimization of reactive extraction of propionic acid with ionic liquids using central composite design

, 2021
Propionic acid is widely utilized in different chemical applications and industries such as plastic, coating, agricultural, chemical and perfume industries.
ÇEHRELİ, Süheyla, Ayan, Emine, BAYLAN, Nilay   +2 more
core   +1 more source

QbD enabled optimization study of the variable concentration of phospholipid and stabilizer in the development of liposomal pastilles of solid dispersion polymeric composite of antihypertensive drug

Journal of Applied Pharmaceutical Research
Background: The study aimed to develop and optimize liposomes of the antihypertensive drug Felodipine (FH) using the Quality by Design (QbD) approach with a 3² Central Composite Design (CCD) in Design Expert software, followed by the development of ...
Deepti Agarwal, Ram Dayal Gupta, Vijay Sharma   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Determination and Optimization of Flour for Producing Crispy Baby Tilapia using Plackett Burman Design and Central Composite Design Method

Squalen, 2017
Research on processing of crispy baby tilapia (Oreochromis niloticus) was conducted to obtain type and proportion of flour on this product with central composite design method.
Syamdidi Syamdidi, Diah Ikasari, Hasta Octavini   +2 more
doaj   +1 more source