Results 221 to 230 of about 223,630 (253)

Central Memory CD4 T Cells

2014
Memory CD4 Tcells can be divided into central memory (TCM) and effector memory (TEM) subsets, which are endowed with different homing and proliferative capacities as well as distinct effector functions (Sallusto et al. 1999). TCM cells can directly home to secondary lymphoid organs and express the lymphoid homing molecules CD62L (L-selectin) and CCR7 ...
Shannon Murray, Rémi Fromentin, Nicolas Chomont   +2 more
openaire   +1 more source

Clinical Scale Central Memory T Cell Enrichment for Adoptive T Cell Therapy

Blood, 2010
Abstract Abstract 5180 The adoptive transfer of genetically engineered lymphocytes is a promising strategy to treat cancer. However, the efficacy of adoptive immunotherapy in humans is often limited and the critical parameters for the in vivo efficacy remain poorly defined.
Anna Casati, J\)rgen Schmitz, Hinrich Abken, Markus Chmielewski, Azam Nahvi, Mark Dudley, Mario Assenmacher, Alexander Scheffold   +7 more
openaire   +1 more source

Increased central memory T cells in patients with chronic pancreatitis

Pancreatology, 2005
A dysregulated immune response has been suggested to be important for the pathogenesis of chronic pancreatitis (CP). Formation of immunological memory is based on the differentiation of naive T lymphocytes to memory T lymphocytes after exposure to antigens and specific cytokines.
Måns, Grundsten, Guang-Zhi, Liu, Johan, Permert, Peter, Hjelmstrom, Jon A, Tsai   +4 more
openaire   +2 more sources

The role and therapeutic strategies for tissue‐resident memory T cells, central memory T cells, and effector memory T cells in psoriasis

Immunology
AbstractPsoriasis is a skin disease that is inflammatory and persistent, causing a high rate of recurrence, poor quality of life, and significant socioeconomic burden. Its main pathological manifestations are abnormal activation and infiltration of T cells and excessive proliferation of keratinocytes (KCs). The great majority of patients with psoriasis
Guoshu Deng, Yulin Zhang, Jiankun Song, Ying Zhang, Qi Zheng, Yue Luo, Xiaoya Fei, Yang Yang, Le Kuai, Bin Li, Ying Luo   +10 more
openaire   +2 more sources

Abstract 1366: A novel stem cell memory T cell subpopulation intermediate to canonical stem cell memory and central memory T cells in human cancer

Cancer Research, 2022
Abstract Stem memory T cells (Tscm) are integral for effective immunotherapy and antitumor responses, but little is known about Tscm immunobiology in solid human tumors. Here we identify self-renewing and multipotent Tscm tumor-infiltrating lymphocytes (TILs) in human cancer and present a novel Tscm subset which expresses CD45RO, is ...
openaire   +1 more source

Increased CD8+ central memory T cells in patients with multiple sclerosis

Multiple Sclerosis Journal, 2007
AT-cell-mediated autoimmune process against central nervous system myelin is believed to underlie the pathogenesis of multiple sclerosis (MS). Formation of immunological memory is based on the differentiation of naïve T cells to memory T cells after exposure to antigens and specific cytokines.
Guang-Zhi, Liu, Li-Bo, Fang, Peter, Hjelmström, Xu-Guang, Gao   +3 more
openaire   +2 more sources

Glucose deprivation enriches for central memory T cells during chimeric antigen receptor-T cell expansion

Cytotherapy, 2019
Background & Aim Chimeric Antigen Receptor (CAR) T cell therapy has emerged as a treatment for systemic cancers such as acute lymphoblastic leukaemia and non-Hodgkin lymphoma with currently two products (Kymriah™ and Yescarta™) approved. In current studies, toxicity and long-term efficacy of CAR-T cells remain challenging. Contributing factors include
A. Amini, F. Veraitch
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TGF-β inhibits central memory cell differentiation in CD8 T-cells (52.14)

The Journal of Immunology, 2012
Abstract Generation of a robust long-term T-cell memory would be expected to fortify vaccines and enhance host protection against infectious diseases and cancer immunotherapy. TGF-β is a well-known immune suppressive cytokine and in initial studies its ability to interfere with the generation of CD8+ central memory (CM) T-cells was ...
Shinji Takai, Jeffrey Schlom, John Greiner   +2 more
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Deciphering the relationship between central and effector memory CD8+ T cells

Trends in Immunology, 2003
Abstract Memory CD8 + T cells can be divided into subpopulations termed central memory cells and effector memory cells based on their phenotype and potential to home to lymph nodes versus non-lymphoid tissues, respectively. Two recent studies, one in humans and one in mice, provide new insight into the lineage relationship between these ...
openaire   +2 more sources

Sleep Matters: CD4+ T Cell Memory Formation and the Central Nervous System

Trends in Immunology, 2019
The mechanisms of CD4+ T-cell memory formation in the immune system are debated. With the well-established concept of memory formation in the central nervous system (CNS), we propose that formation of CD4+ T-cell memory depends on the interaction of two different cell systems handling two types of stored information.
Tanja, Lange, Jan, Born, Jürgen, Westermann   +2 more
openaire   +2 more sources