Results 91 to 100 of about 3,023,998 (402)

Stromagenesis and cancer‐associated fibroblast heterogeneity in primary tumors and metastasis: focus in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
Cancer‐associated fibroblasts (CAFs) play different roles in NSCLC progression and metastasis. Their heterogeneous origins and phenotypes shape the tumor microenvironment and influence metastatic spread. This review highlights NSCLC CAF subtypes, their potential cellular sources, and their differential distribution across primary tumors and distant ...
Alejandro Bernardo, Natalia Díaz‐Valdivia, Patricia Fernández‐Nogueira, Jordi Alcaraz   +3 more
wiley   +1 more source

Hypersensitivity Responses in the Central Nervous System [PDF]

, 2015
Immune-mediated tissue damage or hypersensitivity can be mediated by autospecific IgG antibodies. Pathology results from activation of complement, and antibody-dependent cellular cytotoxicity (ADCC), mediated by inflammatory effector leukocytes include ...
Carsten Tue Berg, Marlene Thorsen Mørch, Nasrin eAsgari, Nasrin eAsgari, Reza eKhorooshi, Trevor eOwens   +5 more
core   +3 more sources

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Psychotherapeutic, pharmacological and other active interventions from the NICE guideline for post-traumatic stress disorder with sleep disorder: systematic review and meta-analysis

BMC Psychiatry
Background Post-traumatic stress disorder (PTSD) is strongly associated with sleep disorders, and current clinical guidelines for PTSD differ in recommending treatment for patients with PTSD associated with sleep disorders.
Yi-Fan Zhao, Cheng-Yang Huang, Zhi-Xin Zhang, Run-Ben Liu, Jia-Ling Liu, Xiao-Zheng Li, Guang-Ling Guo, Chao Zhang   +7 more
doaj   +1 more source

Modelling the spatial organization of cell proliferation in the developing central nervous system [PDF]

, 2010
How far is neuroepithelial cell proliferation in the developing central nervous system a deterministic process? Or, to put it in a more precise way, how accurately can it be described by a deterministic mathematical model?
Clairambault, Jean, Flores, Vladimir, Perthame, Benoit, Rapacioli, Melina, Rofman, Edmundo, Verdes, Rafael   +5 more
core   +3 more sources

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury

Redox Biology
Traumatic brain injury (TBI) triggers a robust inflammatory response that is closely linked to worsened clinical outcomes. S100A8/A9, also known as calprotectin or myeloid-related protein-8/14 (MRP8/14), is an alarmin primarily secreted by activated ...
Guihong Shi, Yiyao Cao, Jianye Xu, Bo Chen, Xu Zhang, Yanlin Zhu, Liang Liu, Xilei Liu, Luyuan Zhang, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Xin Chen, Jianning Zhang, Shu Zhang   +16 more
doaj   +1 more source

Metastatic involvement of the central nervous system in gynecological cancer

Опухоли женской репродуктивной системы, 2014
Metastatic involvement of the central nervous system (CNS) is very rarely observed in gynecological cancer . Ten case histories were analyzed in patients with malignancies of the cervix uteri, endometrium, and ovaries concurrent with metastatic ...
Yu. S. Sidorenko, S. V. Grigorov, V. E. Plotnikova   +2 more
doaj   +1 more source

Extracellular RNA in Central Nervous System Pathologies [PDF]

, 2019
The discovery of extracellular RNA (exRNA) has shifted our understanding of the role of RNA in complex cellular functions such as cell-to-cell communication and a variety of pathologies.
Fischer, Silvia, Preissner, Klaus T., Tielking, Katharina, Vajkoczy, Peter, Xu, Ran   +4 more
core   +1 more source

Designing and Delivering Effective Faculty Development With the Adult Learner in Mind

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT University faculty are busy professionals tasked with many different responsibilities. While they certainly care about student success, their expertise is generally discipline‐specific and strategies for effective and engaging teaching are developed in the classroom along the way.
Nancy V. Winfrey
wiley   +1 more source