Results 41 to 50 of about 3,233,933 (403)

NLRP1 Inflammasomes: A Potential Target for the Treatment of Several Types of Brain Injury

Frontiers in Immunology, 2022
NOD-like receptor (NLR) family pyrin domain-containing 1 (NLRP1) is a member of the NLR family. The NLRP1 inflammasome consists of the NLRP1 protein, the adaptor protein apoptosis-associated speck-like protein containing a CARD domain, and the effector ...
Liang Mi, Liang Mi, Xiaobin Min, Xiaobin Min, Yan Chai, Jianning Zhang, Jianning Zhang, Xin Chen, Xin Chen   +8 more
doaj   +1 more source

Observation of experimental lathyrism in the rat [PDF]

, 1959
The clinical manifestations, roentgenologic studies, and histopathologic findings of the central nervous system of rats with induced lathyrism were described.
Lee, HUN Jae
core   +1 more source

MicroRNA-23a promotes myelination in the central nervous system. [PDF]

, 2013
Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment ...
Fu, Ying-Hui, Heng, Mary Y, Huang, Yong, Lin, Shu-Ting, Ptácek, Louis J, Zhang, Luoying   +5 more
core   +2 more sources

Microglia regulate central nervous system myelin growth and integrity

Nature, 2022
Resident microglia in the central nervous system are identified as the specific macrophage population that regulates myelin growth and integrity. Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that
N. McNamara, David A. D. Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F. J. Bogie, A. Hoffmann, Rebecca K. Holloway, Irene Molina-Gonzalez, Katharine E. Askew, Stephen Mitchell, W. Mungall, Michael Dodds, Carsten Dittmayer, J. Moss, Jamie L. Rose, S. Szymkowiak, Lukas Amann, B. McColl, M. Prinz, T. Spires-Jones, W. Stenzel, K. Horsburgh, Jerome J. A. Hendriks, Clare Pridans, R. Muramatsu, Anna C. Williams, Josef Priller, V. Miron   +27 more
semanticscholar   +1 more source

DNA Methylation Associates With Clinical Courses of Atypical Meningiomas: A Matched Case–Control Study

Frontiers in Oncology, 2022
BackgroundAccounting for 15–20% of all meningiomas, WHO grade II meningiomas represent an intermediate group regarding risk of tumor recurrence. However, even within this subgroup varying clinical courses are observed with potential occurrence of ...
Matthias Millesi, Matthias Millesi, Alice Senta Ryba, Alice Senta Ryba, Johannes A. Hainfellner, Johannes A. Hainfellner, Thomas Roetzer, Thomas Roetzer, Anna Sophie Berghoff, Anna Sophie Berghoff, Matthias Preusser, Matthias Preusser, Gerwin Heller, Gerwin Heller, Erwin Tomasich, Erwin Tomasich, Felix Sahm, Felix Sahm, Karl Roessler, Karl Roessler, Stefan Wolfsberger, Stefan Wolfsberger   +21 more
doaj   +1 more source

Primary central nervous system lymphoma [PDF]

, 2008
O linfoma primário do sistema nervoso central (LPSNC) é um linfoma extralinfonodal que, ao diagnóstico, encontra-se restrito ao parênquima cerebral, às meninges e/ou cordão espinhal e/ou olhos.
BEITLER, Beatriz, BELLESSO, Marcelo, BIZZETTO, Renata, CHAMONE, Dalton A. S., PEREIRA, Juliana, PRACCHIA, Luis Fernando   +5 more
core   +2 more sources

Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases

Frontiers in Immunology, 2022
Neuronal death and inflammatory response are two common pathological hallmarks of acute central nervous system injury and chronic degenerative disorders, both of which are closely related to cognitive and motor dysfunction associated with various ...
Mingming Shi, Mingming Shi, Mingming Shi, Yan Chai, Yan Chai, Jianning Zhang, Jianning Zhang, Jianning Zhang, Xin Chen, Xin Chen, Xin Chen   +10 more
doaj   +1 more source

CENTRAL NERVOUS SYSTEM RESUSCITATION

Emergency Medicine Clinics of North America, 1997
Traumatic injury to the central nervous system induces delayed neuronal death, which may be mediated by acute and chronic neurochemical changes. Experimental identification of these injury mechanisms and elucidation of the neurochemical cascade following trauma may provide enhanced opportunities for treatment with novel neuroprotective strategies.
T K, McIntosh, E, Garde, K E, Saatman, D H, Smith   +3 more
openaire   +2 more sources

Ontogeny of synaptophysin and synaptoporin in the central nervous system [PDF]

, 1993
The expression of the synaptic vesicle antigens synaptophysin (SY) and synaptoporin (SO) was studied in the rat striatum, which contains a nearly homogeneous population of GABAergic neurons. In situ hybridization revealed high levels of SY transcripts in
B. Marquèze-Pouey, Bergmann, Betz, D. Grabs, Goldman-Rakic, Graybiel, H. Betz, Heimer, Hsu, I. Reisert, Iñiguez, Jahn, Jahn, Kita, Knaus, Lahr, Lauder, Leube, Lindefors, M. Bergmann, M. Gratzl, Marquèze-Pouey, Mugnaini, Newman-Gage, Olson, P. Knaus, Reiner, Reisert, Smith, Specht, Specht, Südhof, Thomas, Vernier, W. Ovtscharoff, Wiedenmann, Wilson   +36 more
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Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation.

Annual Review of Immunology, 2021
The immune system of the central nervous system (CNS) consists primarily of innate immune cells. These are highly specialized macrophages found either in the parenchyma, called microglia, or at the CNS interfaces, such as leptomeningeal, perivascular ...
M. Prinz, Takahiro Masuda, Michael A. Wheeler, F. Quintana   +3 more
semanticscholar   +1 more source