Results 161 to 170 of about 24,572,306 (303)

Book Review: Viral Diseases of the Central Nervous System [PDF]

Proceedings of the Royal Society of Medicine, 1976
openaire   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Safety, Immunovirologic, and Central Nervous System Effects of PD-1 Inhibition in People With HIV Without Malignancy. [PDF]

J Infect Dis
Reoma LB, Johnson TP, Cheung K, Smith BR, Pérez L, Wiebold A, Migueles SA, Connors M, Boritz EA, Zahid M, Lai C, Gill J, Shah S, Lyndaker A, Burbelo PD, Maldarelli F, Lane HC, Shin J, Hammoud DA, Nair G, Nath A.   +20 more
europepmc   +1 more source

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A

Advanced Science, EarlyView.
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source

Neurodegenerative and Cognitive Consequences of Long COVID. [PDF]

Int J Mol Sci
Marek-Józefowicz L, Borkowska A, Nedoszytko B, Cubała WJ, Purzycka-Bohdan D, Bohdan M.   +5 more
europepmc   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Tertiary lymphoid structures in neuroinflammation coordinate neuroimmune homeostasis and pathological progression. [PDF]

J Neuroinflammation
Zhang Y, Han P, Zhang X.
europepmc   +1 more source

Effects of bromadiolone poisoning on the central nervous system

, 2017
Meiling Wang,1 Yanfeng Yang,2 Yiwei Hou,1 Wenbin Ma,1 Rui Jia,1 Jinbo Chen1 1Neurology Department, Binzhou Medical University Hospital, Binzhou Medical University, 2Binzhou Blood Center, Binzhou, China Abstract: Cases of rodenticide poisoning ...
Wang M, Yang Y, Chen J, Jia R, Hou Y, Ma W   +5 more
core  

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Varicella-zoster virus encephalitis in an elderly patient with influenza A infection. [PDF]

IDCases
Yordanova R.
europepmc   +1 more source