Results 141 to 150 of about 151,906 (302)

Analysis of miRNAs involved in mouse brain injury upon Coxsackievirus A6 infection

Frontiers in Cellular and Infection Microbiology
IntroductionCoxsackievirus A6 (CV-A6) has emerged as the predominant epidemic strain responsible for hand, foot and mouth disease (HFMD). CV-A6 infection can result in severe clinical manifestations, including encephalitis, meningitis, and potentially ...
Yihao Sun, Yihao Sun, Yilin Hao, Jie Wu, Shasha Qian, Shuo Shen, Yuting Yu   +6 more
doaj   +1 more source

Acute flaccid myelitis cases and outbreaks

As of July 31, 2020, there have been 16 confirmed cases in 2020. There are 38 reports of patients under investigation (PUIs) for 2020. Two patients with confirmed AFM died in the acute phase of their illness, one in 2017 and one in 2020.

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Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Acute disseminated encephalomyelitis: a comprehensive review

Chinese Journal of Contemporary Neurology and Neurosurgery, 2013
Acute disseminated encephalomyelitis (ADEM) is a disease that is characterized by an immune-mediated inflammatory reaction and demyelination in the central nervous system, including optic nerve, brain and spinal cord, which is common in children, but ...
Zheng LIU, Hui-qing DONG
doaj  

Clinical Characteristics of Patients with Confirmed Acute Flaccid Myelitis, United States, 2018 [PDF]

What is already known about this topic? Since U.S. Surveillance for acute flaccid myelitis (AFM) began in 2014, reported cases have peaked biennially. Most cases occur in children during late summer and early fall.What is added by this report?

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Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Emergence of a New Pathogen: A Retrospective Study of HPeV-5 Central Nervous System Disease in Alberta, Canada

Human parechoviruses (HPeVs) are known to cause meningo-encephalitis among neonates and infants. We aimed to describe the epidemiology of HPeVs causing central nervous system infections in Alberta from 2014 to 2019 with comparison of known HPeV-3 and ...
Kanti Pabbaraju, Joseph V. Vayalumkal, Raymond Tellier, Lea Restivo, Dolores Freire Jijon, Kevin Fonseca, Xiaoli Dong, Tarah Lynch, Grace George, Joan L. Robinson   +9 more
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HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment.

, 2010
Occasional cases of viral escape in cerebrospinal fluid (CSF) despite suppression of plasma human immunodeficiency virus type 1 (HIV-1) RNA have been reported. We investigated CSF viral escape in subjects treated with commonly used antiretroviral therapy
Lars Hagberg, Gisslén, Magnus, Price, Richard W, Arvid Edén, Nilsson, Staffan,, Spudich, Serena,, Ed\ue9n, Arvid, Serena Spudich, Gissl\ue9n, Magnus, Svennerholm, Bo, Price, R.W., Magnus Gisslén, Richard W. Price, Spudich, Serena, Edén, Arvid, Dietmar Fuchs, Hagberg, Lars, Hagberg, Lars,, Svennerholm, Bo,, Nilsson, Staffan, Price, R.W.,, Fuchs, Dietmar, Bo Svennerholm, Gisslén, Magnus,, Staffan Nilsson, Fuchs, Dietmar,, Edén, Arvid,   +26 more
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Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Changing incidence of central nervous system diseases in the EuroSIDA cohort

, 2004
A drastic decrease in incidence has been observed for most human immunodeficiency virus (HIV)–related opportunistic manifestations after use of highly active antiretroviral therapy (HAART).
d'Arminio Monforte, A., A. d'Arminio Monforte, Lundgren, J., U. S. Justesen, O. Kirk, C. Katlama, Justesen, Ulrik, Vella, S., P. Cinque, S. Vella, Kirk, O., A. Mocroft, Antunes, F., F. D. Goebel, Goebel, F.D., Mocroft, A., Katlama, C., F. Antunes, J. Lundgren for the EuroSIDA Study Group, Cinque, P.   +19 more
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