Results 131 to 140 of about 149 (149)

Cross-tolerance to centrally injected barbiturates

European Journal of Pharmacology, 1979
Hypnotic responses to intracerebroventricular (i.c.v) injections of either barbital, pentobarbital, R(-) and S(+) mephorbarbital, or racemic metharbital were compared to those produced by phenobarbital. Dose--response relationships were obtained for all except S(+) mephorbarbital and metharbital. Chronic i.c.v.
Henry E. Brezenoff, Mary J. Mycek, William H. Lyness   +2 more
openaire   +3 more sources

The Thymus and Central Tolerance

Hormone and Metabolic Research, 1996
Thymic selection programs T lymphocytes to tolerate self antigens but respond to foreign antigens. The mechanisms involved in self tolerance induction are discussed.
openaire   +3 more sources

Chimerism and central tolerance

Current Opinion in Immunology, 1996
With adequate depletion or inactivation of the pre-existing immune system and establishment of conditions permitting donor hematopoietic stem cell engraftment, a robust state of central deletional tolerance to allogeneic or xenogeneic donors can be induced.
openaire   +2 more sources

A defect in central tolerance in NOD mice

Nature Immunology, 2001
The predisposition of nonobese diabetic (NOD) mice to develop autoimmune disease is usually attributed to defects in peripheral tolerance mechanisms. Here, evidence is presented that NOD mice display a defect in central tolerance (negative selection) of thymocytes. Impaired central tolerance in NOD mice was most prominent in a population of semi-mature
Jonathan Sprent, Hidehiro Kishimoto
openaire   +3 more sources

Central Tolerance of T Cells

International Reviews of Immunology, 1995
The immune system is constructed to tolerate self antigens but give vigorous responses to foreign antigens. How this state of self/nonself discrimination is maintained is controversial. In the case of T cells, many self antigens are transported to the thymus via the bloodstream and induce tolerance (clonal deletion) of self-reactive thymocytes in situ.
openaire   +3 more sources

A unified theory of central tolerance in the thymus [PDF]

Trends in Immunology, 2006
Non-deletional tolerance resulting in the generation of regulatory T cells within the thymus is a key mechanism for the establishment of immunological self-tolerance. How the high-affinity self-reactive regulatory T cells escape negative selection and what type of antigen-presenting cells positively select them within the thymus are unsolved questions.
openaire   +2 more sources

Medullary interplay for central tolerance

Blood, 2011
To establish central tolerance in T cells, Aire, a nuclear protein expressed in medullary thymic epithelial cells, not only induces the ectopic expression of various self-antigens but also facilitates the indirect presentation of medullary thymic epithelial cell (mTEC)–derived self-antigens ...
openaire   +3 more sources

A Nondeletional Mechanism for Central T-Cell Tolerance

Critical Reviews™ in Immunology, 2001
To be positively selected, immature thymocytes must receive signaling through their T-cell receptor (TCR), and engagement of relatively low-affinity self-peptides permits further T-cell maturation. However, mature T cells no longer overtly respond to such low-affinity antigens, indicating that T cells acquire a higher threshold for activation during ...
Anke Kretz-Rommel, Robert L. Rubin
openaire   +3 more sources

Tolerance and cross-tolerance to mescaline and amphetamine as a function of central and peripheral administration

Psychopharmacologia, 1972
Differences in tolerance and cross-tolerance to the behavioral effects of d-amphetamine sulfate and mescaline hydrochloride were studied as a function of intraventricular or intraperitoneal routes of administration. Operant behavior, using a fixed ratio schedule of food reinforcement, was the behavioral variable.
H. A. Tilson, Sheldon B. Sparber
openaire   +3 more sources

Central tolerance: learning self-control in the thymus

Nature Reviews Immunology, 2005
In the past few years, there has been a flurry of discoveries and advancements in our understanding of how the thymus prepares T cells to exist at peace in normal healthy tissue: that is, to be self-tolerant. In the thymus, one of the main mechanisms of T-cell central tolerance is clonal deletion, although the selection of regulatory T cells is also ...
Troy A. Baldwin, Stephen C. Jameson, Kristin A. Hogquist   +2 more
openaire   +3 more sources