Results 41 to 50 of about 225,991 (262)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Development of a low cost IoT framework for continuous surface water quality monitoring in Nigeria

Discover Water
Water pollution continues to pose a significant environmental and public health challenge in many developing nations, where insufficient monitoring and slow detection of contamination often exacerbate waterborne diseases, ecosystem deterioration, and ...
Solomon Gizaw, Abayomi Oyewale, Clement Onime, Kingsley Obodo, Aderonke Okoya, Abimbola Akinyele, Saka Oloyede, Victor Agbagu, Timileyin Okoya, Olasunkanmi Olaiya, Hannah Olukoyejo, Rytis Paškauskas, Ermanno Pietrosemoli, Marco Rainone, Marco Zennaro   +14 more
doaj   +1 more source

Harnessing complex light-matter interactions for point-of-care nano-optical biosensing

Advances in Physics: X
Recent advancements in nanoscale physics have resulted in a paradigm shift towards point-of-care (POC) complex healthcare diagnostics, enabling real-time biomolecular detection.
Vishal Chaudhary, Harsh Sable, Pradeep Bhadola   +2 more
doaj   +1 more source

Topological susceptibility and QCD axion mass: QED and NNLO corrections

Journal of High Energy Physics, 2019
We improve the precision of the topological susceptibility of QCD, and therefore of the QCD axion mass, by including O(α em) and NNLO corrections in the chiral expansion, which amount to 0.65(21)% and -0.71(29)% respectively.
Marco Gorghetto, Giovanni Villadoro
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

NLO friction in symmetry restoring phase transitions

Journal of High Energy Physics
Interactions between bubbles/domain walls and the surrounding medium are a topic of active research, particularly as they apply to friction effects on accelerated expansion during first-order phase transitions.
Aleksandr Azatov, Giulio Barni, Rudin Petrossian-Byrne   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The power of perturbation theory

Journal of High Energy Physics, 2017
We study quantum mechanical systems with a discrete spectrum. We show that the asymptotic series associated to certain paths of steepest-descent (Lefschetz thimbles) are Borel resummable to the full result.
Marco Serone, Gabriele Spada, Giovanni Villadoro   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source