Results 51 to 60 of about 225,991 (262)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Diffractive semi-hard production of a $$J/\psi $$ J / ψ or a $$\Upsilon $$ Υ from single-parton fragmentation plus a jet in hybrid factorization

European Physical Journal C: Particles and Fields, 2022
We investigate the inclusive hadroproduction of a heavy quarkonium ( $$J/\psi $$ J / ψ or $$\Upsilon $$ Υ ), in association with a light-flavored jet, as a testing ground for the semi-hard regime of QCD.
Francesco Giovanni Celiberto, Michael Fucilla   +1 more
doaj   +1 more source

Identifying the barriers and facilitators to transforming a university hospital into a Major Trauma Centre: a qualitative case study using the Theoretical Domains Framework [PDF]

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2015
Method Semi-structured interviews were conducted with 10 participants from a single hospital prior to MTC designation including clinicians, nursing and management staff. A topic guide was designed using the TDF. Interview transcripts were analysed following a framework analysis approach and coded according to TDF domains.
Roberts, Neil, Lorencatto, Fabiana, Manson, Joanna, Jansen, Jan   +3 more
openaire   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Spurion analysis of ℤ M /ℤ 2 non-invertible selection rules: low-order versus all-order zeros

Journal of High Energy Physics
Motivated by recent progress in the spurion analysis of non-invertible selection rules (NISRs) arising from near-group fusion algebras, we further generalize the framework to a class of NISRs obtained from ℤ 2 orbifolding of a ℤ M symmetry, denoted as ℤ ...
Motoo Suzuki, Ling-Xiao Xu
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Gauged permutation invariant matrix quantum mechanics: path integrals

Journal of High Energy Physics
We give a path integral construction of the quantum mechanical partition function for gauged finite groups. Our construction gives the quantization of a system of d, N × N matrices invariant under the adjoint action of the symmetric group S N .
Denjoe O’Connor, Sanjaye Ramgoolam
doaj   +1 more source

Improved Actions for Nuclear Effective Field Theories [PDF]

EPJ Web of Conferences
Effective field theories have been successful in describing nuclei up to the alpha particle but face significant challenges for larger nuclei due to leading-order instabilities.
van Kolck Ubirajara
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source