Results 51 to 60 of about 280,948 (347)

Concise Manual for Ceramic Studies [PDF]

, 2022
This manual is intended to accompany the training of future ceramic specialists in the Arab world. Resulting from the collaboration of four major institutions of French archaeology abroad: the Section française de la direction des Antiquités du Soudan ...

core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

A critical review of the capability approach in Australian Indigenous policy [PDF]

, 2015
The capability approach has recently been used in Australian Indigenous policy formation. Of particular note is how it has been used in some instances to justify current paternalistic and directive policies for Indigenous Australians.
Elise Klein, Klein, Elise
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Factors related to drug approvals: predictors of outcome? [PDF]

, 2017
There is growing interest in characterising factors associated with positive regulatory outcomes for drug marketing authorisations. We assessed empirical studies published over the past 15 years seeking to identify predictive factors.
McAuslane, Neil, Leufkens, Bert, Hoekman, Jarno, Sub Pharmacotherapy, Theoretical, Liberti, Lawrence, Breckenridge, Alasdair, Stolk, Pieter, Innovation Studies, Sub Pharmacoepidemiology, Dynamics of Innovation Systems   +9 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Asymptotic freedom in the Hamiltonian approach to binding of color

EPJ Web of Conferences, 2017
We derive asymptotic freedom and the SU(3) Yang-Mills β-function using the renormalization group procedure for effective particles. In this procedure, the concept of effective particles of size s is introduced. Effective particles in the Fock space build
Gómez-Rocha María
doaj   +1 more source

“C.H.A.M.P. Families”: Description and Theoretical Foundations of a Paediatric Overweight and Obesity Intervention Targeting Parents—A Single-Centre Non-Randomised Feasibility Study [PDF]

International Journal of Environmental Research and Public Health, 2018
Childhood obesity represents a significant global health challenge, and treatment interventions are needed. The purpose of this paper is to describe the components and theoretical model that was used in the development and implementation of a unique parent-focussed paediatric overweight/obesity intervention. C.H.A.M.P.
Kristen C. Reilly, Patricia Tucker, Jennifer D. Irwin, Andrew M. Johnson, Erin S. Pearson, Dirk E. Bock, Shauna M. Burke   +6 more
openaire   +4 more sources

The changing Aboriginal and Torres Strait Islander population: evidence from the 2006–11 Australian Census Longitudinal Dataset [PDF]

, 2015
Populations change and grow through time. Keeping track of this change and associated improvements or worsening in outcomes is a key role for statistical agencies and researchers, and is necessary for an informed and evidence-based policy debate. This is
Nicholas Biddle, Heather Crawford, Crawford, Heather, Biddle, Nicholas   +3 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source