Results 161 to 170 of about 118,231 (380)

CENP-C is a blueprint for constitutive centromere–associated network assembly within human kinetochores

open access: yesJournal of Cell Biology, 2015
CENP-C promotes kinetochore targeting of other constitutive centromere–associated network (CCAN) subunits by directly interacting with the four-subunit CCAN subcomplex CENP-HIKM and spatially organizing the localization of all other CCAN subunits ...
Kerstin Klare   +7 more
semanticscholar   +1 more source

Dynamics of male meiotic recombination frequency during plant development using Fluorescent Tagged Lines in Arabidopsis thaliana [PDF]

open access: yes, 2017
Meiotic homologous recombination plays a central role in creating genetic variability, making it an essential biological process relevant to evolution and crop breeding.
De Storme, Nico, Geelen, Danny, Li, Fan
core   +1 more source

Coordinated gene expression within sustained STAT3‐associated chromatin conformations contributes to hepatocellular carcinoma progression

open access: yesCancer Communications, EarlyView.
Abstract Background Phosphorylated signal transducer and activator of transcription 3 (p‐STAT3) has emerged as a critical modulator of hepatocellular carcinoma (HCC) progression. However, its role in three‐dimensional (3D) chromatin conformation and the expression of genes linked to HCC aggressiveness remains largely unexplored.
Sunyoung Jang   +9 more
wiley   +1 more source

Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets. [PDF]

open access: yes, 2018
Pairing homologous chromosomes is required for recombination. However, in nonmeiotic stages it can lead to detrimental consequences, such as allelic misregulation and genome instability, and is rare in human somatic cells.
Hua, Lisa L, Mikawa, Takashi
core   +1 more source

Lactylation in cancer biology: Unlocking new avenues for research and therapy

open access: yesCancer Communications, EarlyView.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou   +6 more
wiley   +1 more source

Structure of centromere chromatin: from nucleosome to chromosomal architecture

open access: yesChromosoma, 2016
The centromere is essential for the segregation of chromosomes, as it serves as attachment site for microtubules to mediate chromosome segregation during mitosis and meiosis.
T. Schalch, F. Steiner
semanticscholar   +1 more source

The PP2A‐B56 Binding Site LxxIxE Contributes to Asp‐Mediated Spindle Pole Stability

open access: yesCytoskeleton, EarlyView.
ABSTRACT The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule‐associated protein required for correct mitotic ...
Margaux Quiniou   +6 more
wiley   +1 more source

What makes a centromere?

open access: yesExperimental Cell Research, 2020
P. Talbert, S. Henikoff
semanticscholar   +1 more source

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