Results 151 to 160 of about 92,899 (342)
The higher order structure of the centromere
, 1987 The architecture of the centromere region of mouse chromosomes has been studied in cells grown in the presence of 5-azacytidine. This drug interferes with normal condensation producing elongated centromere regions.
C. C. Lin, J. B. Rattner
core +1 more source
Clinical and molecular features of PRCD‐associated retinopathy
Acta Ophthalmologica, EarlyView.Abstract Purpose To describe the clinical and genetic characteristics of patients with biallelic disease‐causing variants in the PRCD (Progressive Rod‐Cone Degeneration) gene. Methods Multicentre, retrospective cohort study of 19 patients from 13 families across nine reference centres in six countries.
Vasil Kostin +30 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2018 Crossover recombination during meiosis is accompanied by a dramatic chromosome reorganization. In Saccharomyces cerevisiae, the onset of meiotic recombination by the Spo11 transesterase leads to stable pairwise associations between previously ...
Lina Yisehak, Amy J. MacQueen
doaj +1 more source
A genetic and historical perspective on the origins of keratitis fugax hereditaria
Acta Ophthalmologica, EarlyView.Abstract Purpose To investigate the genetic and genealogical background of keratitis fugax hereditaria (KFH), a periodic corneal disease caused by the heterozygous pathogenic variant c.61G>C in the NLRP3 gene. KFH is characterized by recurrent unilateral autoinflammatory attacks alternating between the eyes and permanent corneal opacities.
Annamari T. Immonen +7 more
wiley +1 more source
Chromosomal and immune dysregulation underlying granular mitosis in glioblastoma
Brain Pathology, EarlyView.Granular mitosis (GM) morphology is linked to PI3K/PTEN pathway alterations, chromosomal disorganization, and impaired innate immunity. Cells exhibiting GM morphology are associated with localized immune responses within their immediate spatial microenvironment.
Rachel Barboza +8 more
wiley +1 more source
Constitutive centromere-associated network controls centromere drift in vertebrate cells
Journal of Cell Biology, 2017 Centromeres are specified by sequence-independent epigenetic mechanisms, and the centromere position may drift at each cell cycle, but once this position is specified, it may not be frequently moved.
T. Hori +8 more
semanticscholar +1 more source
Immunohistochemistry as a tool for identifying PDGFRA amplification in central nervous system tumors
Brain Pathology, EarlyView.PDGFRA gene amplification is now recognized as a diagnostically and prognostically relevant molecular alteration in central nervous system tumors. Herein, we demonstrated that PDGFRA immunohistochemistry is a highly specific and sensitive biomarker for identifying PDGFRA amplification and should be part of the neuropathologist's routine panel of ...
Arnault Tauziède‐Espariat +5 more
wiley +1 more source
, 2016 Centromeric DNA sequences are not conserved among organisms and centromeres are proposed to be regulated epigenetically. Centromeric transcription is one of the epigenetic factors identified in many eukaryotes, and increasing evidences indicate that ...
Ling, H, Yuen, KWY
core
British Journal of Pharmacology, EarlyView.Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu +9 more
wiley +1 more source
The Behavior of the Maize B Chromosome and Centromere
, 2018 The maize B chromosome is a non-essential chromosome with an accumulation mechanism. The dispensable nature of the B chromosome facilitates many types of genetic studies in maize.
Handong Su +4 more
core +1 more source