Results 161 to 170 of about 87,751 (339)

Topoisomerase-II mediated biochemical mapping of centromeres and nitroreductase mediated drug metabolism in Trypanosomatids

, 2012
PhDThe protozoan parasites Trypanosoma cruzi and Trypanosoma brucei are the causative agents of Chagas disease and Human African sleeping sickness respectively.
Bot, Christopher
core  

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Chromosomal and immune dysregulation underlying granular mitosis in glioblastoma

Brain Pathology, EarlyView.
Granular mitosis (GM) morphology is linked to PI3K/PTEN pathway alterations, chromosomal disorganization, and impaired innate immunity. Cells exhibiting GM morphology are associated with localized immune responses within their immediate spatial microenvironment.
Rachel Barboza, Xuan Wang, August Lin, Eric Liu, Pramath Kakodkar, Yayuan Zhao, Quinn Le, Christina A. Castellani, Qi Zhang   +8 more
wiley   +1 more source

Immunohistochemistry as a tool for identifying EGFR amplification in CNS tumors. [PDF]

Brain Pathol
EGFR gene amplification constitutes a diagnostic hallmark for glioblastoma, IDH‐wildtype (GB, IDH‐WT). Herein, we demonstrated that EGFR IHC is a highly specific and sensitive biomarker for identifying EGFR amplification and should be part of the neuropathologist's routine panel of antibodies.
Tauziède-Espariat A, Bah M, Sassi F, Pucelle N, Berthaud C, Mandoula M, Dababou Z, Carnes N, Brissez L, Hasty L, Servant E, Métais A, Varlet P.   +12 more
europepmc   +2 more sources

Centromere on the Move [PDF]

Genome Research, 2001
L H, Wong, K H, Choo
openaire   +2 more sources

Evolution of centromere organization in ascomycetous fungi.

, 2016
(A) Phylogeny of ascomycetous fungi showing the diverse nature of centromere structure. An unrooted phylogenetic tree was constructed using 573 uniformly evolving orthologous gene families (see methods).
Sreedevi Padmanabhan (2158066), Kaustuv Sanyal (169834), Sundar Ram Sankaranarayanan (2158060), Krishnendu Guin (2158069), Rahul Siddharthan (53463), Gautam Chatterjee (553515), Yogitha Thattikota (2158063)   +6 more
core   +1 more source

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

British Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu, Da‐Hao Mai, Xing‐Ming Zhong, Li‐Ting Huang, Lan‐Ting Fu, He‐Cai Wang, Ke Wang, Hai‐Yan Li, Qiu‐He Chen, Yang Chen   +9 more
wiley   +1 more source

A Centromere Attribute Integration Approach to Centromere Identification

, 1996
Automated and nonautomated approaches to chromosome classification involves assessing several chromosome attributes. The centromere is an important attribute which provides insight to other features such as chromosome orientation and the banding pattern ...
Gader, Paul D., Stanley, R. Joe, Caldwell, Charles William, Keller, James M.   +3 more
core  

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, EarlyView.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

Determining the Mechanism of CSR-1 RNAi Pathway in Organizing Holocentromere in Caenorhabditis elegans

, 2016
CSR-1 RNAi pathway is required for the holocentromere organization and proper chromosome segregation in Caenorhabditis elegans. It remains obscure how this pathway functionally links to these two events. A previous study showed that germline genes, which
Wong, YYC, Yuen, KWY
core