Results 161 to 170 of about 92,899 (342)

Ionizing Radiation and Ultraviolet Light Irradiation‐Associated DNA Damage Increasing Genomic Instability Risk

Cancer Science, EarlyView.
UV irradiation induces two major types of pyrimidine dimers, CPDs and 6–4PPs. Whereas 6–4PPs efficiently induce cell‐cycle arrest, CPDs do not and frequently persist into S phase. As a result, DSBs can arise in the presence of unrepaired CPDs after 6–4PPs have been repaired, increasing the risk of genomic instability.
Ken‐ichi Yoshioka, Yusuke Matsuno, Rika Kusumoto‐Matsuo   +2 more
wiley   +1 more source

Mechanisms of transgenerational centromere inheritance [PDF]

, 2016
Centromeres control genetic inheritance by directing chromosome segregation, but centromeres in most species are not genetically encoded. Instead, centromeres are specified epigenetically by the presence of Centromere Protein A (CENP-A), a histone H3 ...
Smoak, Evan Michael
core  

Charting the course of Sjögren's disease: A historical analysis of scientific progress

European Journal of Oral Sciences, EarlyView.
Abstract Sjögren's disease (SjD) bears the name of the Swedish ophthalmologist Henrik Sjögren. His 1933 doctoral thesis on keratoconjunctivitis sicca ignited interest, yet much remains under debate. SjD is an autoimmune disorder that primarily affects the exocrine glands, particularly the salivary and lacrimal glands, leading to a dryness of the eyes ...
Diego Ustárroz Cantali, Fabiola Reis de Oliveira, Denise Cantarelli Machado, Moisés Evandro Bauer   +3 more
wiley   +1 more source

Centromere-size reduction and chromatin state dynamics following intergenomic hybridization in cotton.

PLoS Genetics
Centromeres are pivotal for accurate chromosome segregation, yet their regulation and evolutionary dynamics remain poorly understood. Here, we investigate centromeres of the diploid species Gossypium anomalum (Ga, B-genome) that were transferred into ...
Jinlei Han, Guanjing Hu, Yan Dai, Xin Zhang, Jingjing Tian, Jialiang Zhou, Xinqi Xu, Qi Chen, Xiaobing Kou, Lei Xu, Xinyu Wu, Ziying Sun, Jiahui Geng, Lin Li, Chenyu Qiu, Teame Gereziher Mehari, Baohua Wang, Hui Zhang, Xinlian Shen, Zhenzhen Xu, Jonathan F Wendel, Kai Wang   +21 more
doaj   +1 more source

A replication-coupled repair based model of centromere inheritance.

, 2014
(A) A replication-coupled repair based model for propagation of CENP-ACaCse4 chromatin at an early replicating centromere. During S phase, replication forks, originating from proximal conserved early origins, stall at the kinetochore.
Kaustuv Sanyal (169834), Dharani Dhar Dubey (555234), Germán Larriba (208904), Sreyoshi Mitra (555232), Jonathan Gómez-Raja (555233)   +4 more
core   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Low frequency of MTAP co‐deletion with CDKN2A in peritoneal mesothelioma suggests an independent diagnostic role for MTAP

Histopathology, EarlyView.
Aims Loss of MTAP expression by immunohistochemistry (IHC) is widely used as a surrogate for CDKN2A homozygous deletion (HD) in pleural mesothelioma (PM), but its diagnostic value in peritoneal mesothelioma (PeM) is less well defined. We investigated whether the observed limited reliability of MTAP IHC in PeM reflects a lower frequency of MTAP/CDKN2A ...
Andrea Quaranta, Donato Mancini, Concetta Caporusso, Andrea Marzullo, Luigi Vimercati, Cecilia Salzillo, Federica Pezzuto, Fiorella Calabrese, Gabriella Serio   +8 more
wiley   +1 more source

A Functional Assay for Centromere-Associated Sister Chromatid Cohesion

, 1999
Cohesion of sister chromatids occurs along the entire length of chromosomes, including the centromere where it plays essential roles in chromosome segregation. Here, minichromosomes in the budding yeast Saccharomyces cerevisiae
Douglas Koshland, Paul C. Megee
core   +1 more source

Survival among patients with systemic sclerosis‐associated pulmonary arterial hypertension in the Australian scleroderma cohort study

Internal Medicine Journal, EarlyView.
Abstract Background and Aims Systemic sclerosis (scleroderma; SSc) patients can develop pulmonary arterial hypertension (PAH), which is a leading cause of death. We sought to evaluate severity, therapeutic strategy and survival of SSc‐PAH in the Australian Scleroderma Cohort Study (ASCS).
Zoe Brown, Dylan Hansen, Kathleen Morrisroe, Nava Ferdowsi, Laura Ross, Wendy Stevens, Maryam Tabesh, Joanne Sahhar, Gene‐Siew Ngian, Diane Apostolopoulos, Kimti Kumar, Jennifer G. Walker, Susanna Proudman, Mandana Nikpour   +13 more
wiley   +1 more source

FBXO47 regulates centromere pairing as key component of centromeric SCF E3 ligase in mouse spermatocytes

Communications Biology
Centromere pairing is crucial for synapsis in meiosis. This study delves into the Skp1-Cullin1-F-box protein (SCF) E3 ubiquitin ligase complex, specifically focusing on F-box protein 47 (FBXO47), in mouse meiosis.
Ani Ma, Yali Yang, Lianbao Cao, Lijun Chen, Jian V. Zhang   +4 more
doaj   +1 more source