Results 201 to 210 of about 26,352 (303)
Cell Proliferation, EarlyView.PDHA2, a testis‐specific subunit of pyruvate dehydrogenase, is required for the conversion of pyruvate to acetyl‐CoA. Its absence results in decreased acetyl‐CoA and precursors for metabolites and energy during spermatogenesis. This results in decreased histone acetylation, defective chromosome structure and moderately reduced crossovers, ultimately ...
Guoqiang Wang +9 more
wiley +1 more source
Reconstituting Drosophila Centromere Identity in Human Cells
Cell Reports, 2019 Summary: The centromere is an essential chromosomal region required for accurate chromosome segregation. Most eukaryotic centromeres are defined epigenetically by the histone H3 variant, centromere protein (CENP)-A, yet how its self-propagation is ...
Virginie Roure +7 more
doaj
Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) sequesters misfolded proteins during stress
The FEBS Journal, EarlyView.Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) is a major co‐chaperone to both Hsp90 and Hsp70. We find that misbalanced expression of Sti1 in yeast and mammalian cells causes severe growth defects. Deletion of STI1 causes an accumulation of soluble misfolded ubiquitinated proteins and a strong activation of the heat shock response.
Benjamin S. Rutledge +7 more
wiley +1 more source
The FEBS Journal, EarlyView.We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika +7 more
wiley +1 more source
Purification of a protein binding to the CDEI subregion of Saccharomyces cerevisiae centromere DNA.
, 1989 Weidong Jiang, Peter Philippsen
openalex +1 more source
D7S448 detects aHindIII polymorphism located in the centromere region of chromosome 7 [PDF]
, 1991 Michael Dean +6 more
openalex +1 more source
Histopathology, EarlyView.Here we report the features of 24 BAP1‐inactivated melanocytic tumours including 19 BAP1‐inactivated melanocytomas (BIMs) and five BAP1‐inactivated melanomas. BIMs have a favourable prognosis, even those with multiple copy number aberrations (CNAs).
Joseph S. Durgin +9 more
wiley +1 more source
Medical genetics: advances in brief: Integration of human -satellite DNA into simian chromosomes: centromere protein binding and disruption of normal chromosome segregation [PDF]
, 1992 Nalin Thakker
openalex +1 more source
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT Swedish Warmblood horses (SWB) are bred for show jumping and/or dressage with young horse test scores as indicator traits. This study aimed to investigate possible candidate genes and regions of importance for evaluated and linearly scored young horse test traits.
Anahit Nazari‐Ghadikolaei +4 more
wiley +1 more source