Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam+12 more
wiley +1 more source
Recombination between two mouset-haplotypes (tw12tfandtLub-1): segregation of lethal factors relative to centromere and tufted (tf) locus [PDF]
Hubert Condamine+2 more
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Comparative gene mapping in Arabidopsis lyrata chromosomes 1 and 2 and the corresponding A. thaliana chromosome 1: recombination rates, rearrangements and centromere location [PDF]
Charlesworth, D+4 more
core +1 more source
Abstract Allium oreophilum, hitherto the representative of the monotypic A. subg. Porphyroprason from the second evolutionary lineage of Allium, is studied in detail. Over about 150 years, A. oreophilum was regarded as a somewhat polymorphous species with two synonyms, all described in the 19th century.
Nikolai Friesen+13 more
wiley +1 more source
A molecular cytogenetic perspective on chromosome biology and crop improvement. [PDF]
Abstract The age of molecular cytogenetic analysis of crop plants dawned in the late 1960s and early 1970s with new advances in the identification of somatic chromosomes by C‐banding and fluorescence in situ hybridization concurrent with advances in DNA cloning, sequencing, and mapping. In this perspective article dedicated to Ronald Phillips, I review
Gill BS.
europepmc +2 more sources
Russian wheat aphid: a model for genomic plasticity and a challenge to breeders
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn+8 more
wiley +1 more source
This work focused on arowana fishes (Teleostei, Osteoglossiformes) as a model; their widespread intercontinental distribution and basal phylogenetic position within Teleostei make them a compelling model for evolutionary research, especially in the realm of satDNA molecular evolution. Through the integration of genomic and chromosomal data, we analyzed
Fernando Henrique Santos de Souza+9 more
wiley +1 more source
Isodicentric X chromosome in a moderately tall patient with gonadal dysgenesis: lack of effect of functional centromere on inactivation pattern. [PDF]
Janet Robertson+3 more
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ABSTRACT Yellow monkeyflowers (Mimulus guttatus complex, Phrymaceae) are a powerful system for studying ecological adaptation, reproductive variation, and genome evolution. To initiate pan‐genomics in this group, we present four chromosome‐scale assemblies and annotations of accessions spanning a broad evolutionary spectrum: two from a single M ...
John T. Lovell+21 more
wiley +1 more source
Tightly centromere-linked gene (SPO15) essential for meiosis in the yeast Saccharomyces cerevisiae.
Elaine Yeh, J. Carbon, Kerry Bloom
openalex +3 more sources