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Centromere Protein A Goes Far Beyond the Centromere in Cancers
Molecular Cancer Research, 2022Abstract Centromere dysfunctions leading to numerical chromosome alterations are believed to be closely related to human cancers. As a centromere-specific protein, centromere protein A (CENP-A) replaces the histone H3 in centromeres and is therefore considered a key factor of centromere identity ...
Haiping Wang +3 more
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Indirect immunofluorescence of inactive centromeres as indicator of centromeric function
Human Genetics, 1986Two previous single case reports from the literature showed the presence or absence of centromeric antigens at the site of the inactive centromeres in one (X;X) and in one (9;11) dicentric chromosome. We studied nine different dicentric chromosomes using anticentromeric antibodies and immunofluorescence techniques.
PERETTI, DILETTA +4 more
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2008
Plant centromeres are generally composed of tandem arrays of simple repeats that are typical of a particular species, but that evolve rapidly. Centromere specific retroelements are also present. These arrays associate with a centromere specific variant of histone H3 that anchors the site of the kinetochore.
J C, Lamb, W, Yu, F, Han, J A, Birchler
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Plant centromeres are generally composed of tandem arrays of simple repeats that are typical of a particular species, but that evolve rapidly. Centromere specific retroelements are also present. These arrays associate with a centromere specific variant of histone H3 that anchors the site of the kinetochore.
J C, Lamb, W, Yu, F, Han, J A, Birchler
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Yeast, 1987
Significant progress has been made toward understanding the roles played by conserved centromere DNA sequences in both mitotic and meiotic chromosome segregation. We are just beginning to formulate a picture of what a yeast kinetochore actually looks like and what components other than CEN DNA are necessary for function.
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Significant progress has been made toward understanding the roles played by conserved centromere DNA sequences in both mitotic and meiotic chromosome segregation. We are just beginning to formulate a picture of what a yeast kinetochore actually looks like and what components other than CEN DNA are necessary for function.
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Current Opinion in Genetics & Development, 2007
At the foundation of all eukaryotic kinetochores is a unique histone variant, known as CenH3 (centromere histone H3). We are starting to identify the histone chaperones responsible for CenH3 deposition at centromere DNA, and the mechanisms that restrict CenH3 from chromosome arms.
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At the foundation of all eukaryotic kinetochores is a unique histone variant, known as CenH3 (centromere histone H3). We are starting to identify the histone chaperones responsible for CenH3 deposition at centromere DNA, and the mechanisms that restrict CenH3 from chromosome arms.
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Chromosoma, 1996
We report the identification of a family of sequences located by in situ hybridisation to the centromeres of all the Triticeae chromosomes studied, including the supernumerary and midget chromosomes, the centromeres of all maize chromosomes and the heterochromatic regions of rice chromosomes.
Aragón-Alcaide, L +4 more
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We report the identification of a family of sequences located by in situ hybridisation to the centromeres of all the Triticeae chromosomes studied, including the supernumerary and midget chromosomes, the centromeres of all maize chromosomes and the heterochromatic regions of rice chromosomes.
Aragón-Alcaide, L +4 more
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The Centromere Paradox: Stable Inheritance with Rapidly Evolving DNA
Science, 2001Every eukaryotic chromosome has a centromere, the locus responsible for poleward movement at mitosis and meiosis. Although conventional loci are specified by their DNA sequences, current evidence favors a chromatin-based inheritance mechanism for ...
S. Henikoff, K. Ahmad, Harmit S. Malik
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Chromosoma, 1989
Human anti-centromere sera from scleroderma patients were used to detect centromere antigens of mouse fibroblast cells. An Mr = 59,000 centromere protein was localized exclusively on mitotic chromosomes. The association of this protein with the mitotic chromosomes proved to be DNase I sensitive.
Judit Kereso +3 more
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Human anti-centromere sera from scleroderma patients were used to detect centromere antigens of mouse fibroblast cells. An Mr = 59,000 centromere protein was localized exclusively on mitotic chromosomes. The association of this protein with the mitotic chromosomes proved to be DNase I sensitive.
Judit Kereso +3 more
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1996
Anticentromere antibodies (ACA) recognise a family of proteins that remain in the centromere region of eukaryotic cells throughout the cell cycle. The three main centromere proteins recognised (CENP-A, CENP-B and CENP-C) localise to separate parts of the centromeric heterochromatin and closely associated kinetochore, and together form targets for a ...
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Anticentromere antibodies (ACA) recognise a family of proteins that remain in the centromere region of eukaryotic cells throughout the cell cycle. The three main centromere proteins recognised (CENP-A, CENP-B and CENP-C) localise to separate parts of the centromeric heterochromatin and closely associated kinetochore, and together form targets for a ...
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Directing the Centromere Guardian
Science, 2010Histone phosphorylation controls the chromosomal localization of a protein family that functions in chromosome segregation during cell division.
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