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Computational centrosomics: An approach to understand the dynamic behaviour of centrosome
Gene, 2012Centrosomes are the key regulating element of cell cycle progression. Aberrations in their functional mechanism leads to several cancer related disorders. Although genomic studies in the field of centrosome have been extensively carried out, with the lack of structural conformation, the proteomic analysis of pathological genetic mutation is still a ...
Rituraj Purohit, Ambuj Kumar
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Centrosomes in Branching Morphogenesis
2019The centrosome, a major microtubule organizer, has important functions in regulating the cytoskeleton as well as the position of cellular structures and orientation of cells within tissues. The centrosome serves as the main cytoskeleton-organizing centre in the cell and is the classical site of microtubule nucleation and anchoring.
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Centrosomes and The Cell Cycle
Journal of Cell Science, 1989ABSTRACT Centrosomes are the ensemble of organelles that form the poles of the mitotic spindle. We have examined the properties of the mechanisms that control the precise doubling, or reproduction, of centrosomes during the cell cycle. A functional analysis of this event in sea urchin eggs indicates that it is limited by the reproduction
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Identification of centrosome kinases
2001Publisher Summary Centrosome kinases can be identified primarily through one of two routes—(1) through performing subcellular localization studies on previously characterized protein kinases and (2) through screens directed at identifying cell cycle defects in genetically tractable organisms.
Andrew M. Fry, Alison J. Faragher
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