Results 51 to 60 of about 15,728 (128)

Mutant p53 drives the loss of heterozygosity by the upregulation of Nek2 in breast cancer cells

Breast Cancer Research, 2020
Background Mutations in one allele of the TP53 gene in early stages are frequently followed by the loss of the remaining wild-type p53 (wtp53) allele (p53LOH) during tumor progression.
Amr Ghaleb, Malik Padellan, Natalia Marchenko   +2 more
doaj   +1 more source

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

The FEBS Journal, Volume 293, Issue 11, Page 3140-3165, June 2026.
Intra‐tumoral oxygen deprivation (hypoxia) promotes the activation of hypoxia‐inducible factors (HIFs) that orchestrate the transcriptional adaptation of cancer cells to hypoxia. Hypoxia is prevalent in hepatocellular carcinoma (HCC), a cancer type with limited therapeutic options.
Ioanna‐Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis   +6 more
wiley   +1 more source

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, Volume 293, Issue 12, Page 3663-3682, June 2026.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source

Prolonged overexpression of PLK4 leads to formation of centriole rosette clusters that are connected via canonical centrosome linker proteins

Scientific Reports
Centrosome amplification is a hallmark of cancer and PLK4 is one of the responsible factors for cancer associated centrosome amplification. Increased PLK4 levels was also shown to contribute to generation of cells with centriole amplification in ...
Selahattin Can Ozcan, Batuhan Mert Kalkan, Enes Cicek, Ata Alpay Canbaz, Ceyda Acilan   +4 more
doaj   +1 more source

A centrally positioned cluster of multiple centrioles in antigen-presenting cells fosters T cell activation

Nature Communications
Cellular polarization plays a crucial role in regulating immunological processes and is often associated with reorientation of the centrosome. During immune synapse formation, centrosome repositioning in lymphocytes assists in T cell activation.
Isabel Stötzel, Ann-Kathrin Weier, Apurba Sarkar, Subhendu Som, Luisa Bach, Peter Konopka, Eliška Miková, Shaunak Ghosh, Jan Böthling, Mirka Homrich, Laura Schaedel, Uli Kazmaier, Konstantinos Symeonidis, Stefan Ebner, Philip Weidner, Zeinab Abdullah, Felix Meissner, Stefan Uderhardt, Miroslav Hons, Dirk Baumjohann, Raja Paul, Heiko Rieger, Eva Kiermaier   +22 more
doaj   +1 more source

Growth Factor Dependent Regulation of Centrosome Function and Genomic Instability by HuR

Biomolecules, 2015
The mRNA binding protein HuR is over expressed in cancer cells and contributes to disease progression through post-transcriptional regulation of mRNA. The regulation of HuR and how this relates to glioma is the focus of this report. SRC and c-Abl kinases
Natalia Filippova, Xiuhua Yang, Louis Burt Nabors   +2 more
doaj   +1 more source

STIL overexpression shortens lifespan and reduces tumor formation in mice.

PLoS Genetics
Centrosomes are the major microtubule organizing centers of animal cells. Supernumerary centrosomes are a common feature of human tumors and associated with karyotype abnormalities and aggressive disease, but whether they are cause or consequence of ...
Amira-Talaat Moussa, Marco R Cosenza, Timothy Wohlfromm, Katharina Brobeil, Anthony Hill, Annarita Patrizi, Karin Müller-Decker, Tim Holland-Letz, Anna Jauch, Bianca Kraft, Alwin Krämer   +10 more
doaj   +1 more source

The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplication

Nature Communications
Copy number control of DNA and centrosomes is essential for accurate genetic inheritance. DNA replication and centrosome duplication have been recognized as parallel key events for cell division.
Kyohei Matsuhashi, Kei K. Ito, Kaho Nagai, Akira Sanada, Koki Watanabe, Kasuga Takumi, Atsushi Toyoda, Masamitsu Fukuyama, Shohei Yamamoto, Takumi Chinen, Grant S. Stewart, Shoji Hata, Daiju Kitagawa   +12 more
doaj   +1 more source

CENPA overexpression promotes genome instability in pRb-depleted human cells

Molecular Cancer, 2009
Background Aneuploidy is a hallmark of most human cancers that arises as a consequence of chromosomal instability and it is frequently associated with centrosome amplification.
Lentini Laura, Schillaci Tiziana, Amato Angela, Di Leonardo Aldo   +3 more
doaj   +1 more source

β-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53.

PLoS ONE
Colorectal cancer is the third most common cancer and the second leading cause of cancer-related deaths worldwide. The centrosome is the main microtubule-organizing center in animal cells and centrosome amplification is a hallmark of cancer cells.
Mohamed Bourmoum, Nikolina Radulovich, Amit Sharma, Johnny M Tkach, Ming-Sound Tsao, Laurence Pelletier   +5 more
doaj   +1 more source