Results 61 to 70 of about 15,728 (128)

USP9X regulates centrosome duplication and promotes breast carcinogenesis

Nature Communications, 2017
USP9X is a deubiquitinating enzyme with many known substrates and functions; it has been linked to cancer but the mechanisms remain unclear. Here Liet al. report that USP9X stabilizes the centrosomal protein CEP131 leading to centrosome amplification and
Xin Li, Nan Song, Ling Liu, Xinhua Liu, Xiang Ding, Xin Song, Shangda Yang, Lin Shan, Xing Zhou, Dongxue Su, Yue Wang, Qi Zhang, Cheng Cao, Shuai Ma, Na Yu, Fuquan Yang, Yan Wang, Zhi Yao, Yongfeng Shang, Lei Shi   +19 more
doaj   +1 more source

Epstein–Barr virus particles induce centrosome amplification and chromosomal instability

Nature Communications, 2017
Infection with Epstein–Barr virus (EBV) is associated with increased risk of cancer development. Here the authors show that EBV particles, and more specifically the viral protein BNRF1, induce centrosome amplification and chromosomal instability in host ...
Anatoliy Shumilov, Ming-Han Tsai, Yvonne T. Schlosser, Anne-Sophie Kratz, Katharina Bernhardt, Susanne Fink, Tuba Mizani, Xiaochen Lin, Anna Jauch, Josef Mautner, Annette Kopp-Schneider, Regina Feederle, Ingrid Hoffmann, Henri-Jacques Delecluse   +13 more
doaj   +1 more source

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science
Centrosome amplification in cancer cells produces excess centrosomes that cluster and decluster throughout the cell cycle, a process critical for tumorigenesis.
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
doaj   +1 more source

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

Nature Communications, 2017
Activated PI3K causes cancer, but the role of active PI3K mutations in early stages of malignancy are unclear. Here, the authors show in a mouse model that active PI3K induces centrosome amplification via AKT, ROCK, CDK2/Cyclin E and nucleophosmin, and ...
Inma M. Berenjeno, Roberto Piñeiro, Sandra D. Castillo, Wayne Pearce, Nicholas McGranahan, Sally M. Dewhurst, Valerie Meniel, Nicolai J. Birkbak, Evelyn Lau, Laurent Sansregret, Daniele Morelli, Nnennaya Kanu, Shankar Srinivas, Mariona Graupera, Victoria E. R. Parker, Karen G. Montgomery, Larissa S. Moniz, Cheryl L. Scudamore, Wayne A. Phillips, Robert K. Semple, Alan Clarke, Charles Swanton, Bart Vanhaesebroeck   +22 more
doaj   +1 more source

A GPER-PKA-Centrin axis regulates centrosome numbers and centriole integrity in colon cancer cells

Communications Biology
Centrosome amplification is a hallmark of colorectal cancer (CRC), yet its molecular origins remain elusive. Protein Kinase A (PKA), anchored to centrosomes, regulates a number of mitotic processes, though its role in maintaining centrosome integrity ...
Jeanine Fahrländer, Miriam Bühler, Julia Martins Shih, Catrin Zordick, Madleen Busse, Markus Becker, Gilbert Schönfelder, Ailine Stolz   +7 more
doaj   +1 more source

Molecular landscape and functional characterization of centrosome amplification in ovarian cancer. [PDF]

Nat Commun, 2023
Sauer CM, Hall JA, Couturier DL, Bradley T, Piskorz AM, Griffiths J, Sawle A, Eldridge MD, Smith P, Hosking K, Reinius MAV, Morrill Gavarró L, Mes-Masson AM, Ennis D, Millan D, Hoyle A, McNeish IA, Jimenez-Linan M, Martins FC, Tischer J, Vias M, Brenton JD.   +21 more
europepmc   +1 more source

Elucidating Differences in Early-Stage Centrosome Amplification in Primary and Immortalized Mouse Cells. [PDF]

Int J Mol Sci, 2023
Tanaka M, Yamada M, Mushiake M, Tsuda M, Miwa M.   +4 more
europepmc   +1 more source

Centrosome amplification fine tunes tubulin acetylation to differentially control intracellular organization. [PDF]

EMBO J, 2023
Monteiro P, Yeon B, Wallis SS, Godinho SA.   +3 more
europepmc   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source